AU580822B2 - New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
AU580822B2
AU580822B2 AU51006/85A AU5100685A AU580822B2 AU 580822 B2 AU580822 B2 AU 580822B2 AU 51006/85 A AU51006/85 A AU 51006/85A AU 5100685 A AU5100685 A AU 5100685A AU 580822 B2 AU580822 B2 AU 580822B2
Authority
AU
Australia
Prior art keywords
acid
compound
general formula
dihydro
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU51006/85A
Other languages
English (en)
Other versions
AU5100685A (en
Inventor
Jens-Peter Holck
Wolfgang Kampe
Alfred Mertens
Bernd Muller-Beckmann
Wolfgang Schaumann
Klaus Strein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU5100685A publication Critical patent/AU5100685A/en
Application granted granted Critical
Publication of AU580822B2 publication Critical patent/AU580822B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU51006/85A 1984-12-14 1985-12-09 New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them Ceased AU580822B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843445669 DE3445669A1 (de) 1984-12-14 1984-12-14 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3445669 1984-12-14

Publications (2)

Publication Number Publication Date
AU5100685A AU5100685A (en) 1986-06-19
AU580822B2 true AU580822B2 (en) 1989-02-02

Family

ID=6252801

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51006/85A Ceased AU580822B2 (en) 1984-12-14 1985-12-09 New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (2) US4710510A (enExample)
EP (1) EP0186010B1 (enExample)
JP (1) JPS61158984A (enExample)
AT (1) ATE49970T1 (enExample)
AU (1) AU580822B2 (enExample)
CA (1) CA1262908A (enExample)
CS (1) CS276403B6 (enExample)
DD (1) DD242045A5 (enExample)
DE (2) DE3445669A1 (enExample)
DK (1) DK579185A (enExample)
ES (1) ES8702409A1 (enExample)
FI (1) FI79318C (enExample)
GR (1) GR852979B (enExample)
HU (1) HU194241B (enExample)
SU (1) SU1440348A3 (enExample)
ZA (1) ZA859382B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
DE3855327D1 (de) * 1987-12-30 1996-07-04 Orion Yhtymae Oy Heterocyclische Verbindungen
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
WO2002070478A1 (en) * 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
WO2002072549A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
JP2007518816A (ja) * 2004-01-23 2007-07-12 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び炎症性及び神経因性疼痛の治療におけるこれらの使用
ES2590531T3 (es) 2012-09-13 2016-11-22 F. Hoffmann-La Roche Ag 2-oxo-2,3-dihidro-indoles para el tratamiento de trastornos del SNC
SG10201900631TA (en) 2014-08-01 2019-02-27 Nuevolution As Compounds active towards bromodomains
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5224586A (en) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh New pyrrolobenzimidazoles, processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof
AU6216586A (en) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
EP0033612B1 (en) * 1980-02-02 1984-04-11 Beecham Group Plc Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them
FR2476644A1 (fr) * 1980-02-21 1981-08-28 Sarget Lab Orthoarylydeneaminophenethylamine, leur preparation et leur utilisation therapeutique
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
SU1068439A1 (ru) * 1982-10-28 1984-01-23 Новокузнецкий научно-исследовательский химико-фармацевтический институт Производные имидазо(4,5- @ ) индолов
US4579865A (en) * 1983-02-14 1986-04-01 Usv Pharmaceutical Corp. Benzofuranyl carbamates
US4548943A (en) * 1984-05-11 1985-10-22 E. I. Du Pont De Nemours And Company Antiinflammatory, analgesic, or anti-primary dysmenorrheal arylmethylene- and arylmethylindenoimidazoles
GR851085B (enExample) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5224586A (en) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh New pyrrolobenzimidazoles, processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof
AU6216586A (en) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SU1440348A3 (ru) 1988-11-23
CA1262908A (en) 1989-11-14
ES8702409A1 (es) 1987-01-16
EP0186010B1 (de) 1990-01-31
GR852979B (enExample) 1986-04-08
ES549776A0 (es) 1987-01-16
DE3445669A1 (de) 1986-06-19
DD242045A5 (de) 1987-01-14
DK579185A (da) 1986-06-15
HUT40436A (en) 1986-12-28
FI854926A7 (fi) 1986-06-15
CS276403B6 (en) 1992-05-13
ZA859382B (en) 1986-08-27
JPS61158984A (ja) 1986-07-18
US4710510A (en) 1987-12-01
US4810801A (en) 1989-03-07
FI854926A0 (fi) 1985-12-12
EP0186010A1 (de) 1986-07-02
FI79318B (fi) 1989-08-31
DK579185D0 (da) 1985-12-13
AU5100685A (en) 1986-06-19
DE3575725D1 (de) 1990-03-08
HU194241B (en) 1988-01-28
ATE49970T1 (de) 1990-02-15
JPH0471914B2 (enExample) 1992-11-16
CS919585A3 (en) 1992-01-15
FI79318C (fi) 1989-12-11

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