CA1248533A - Phenylacetonitrile derivatives - Google Patents

Phenylacetonitrile derivatives

Info

Publication number
CA1248533A
CA1248533A CA000490499A CA490499A CA1248533A CA 1248533 A CA1248533 A CA 1248533A CA 000490499 A CA000490499 A CA 000490499A CA 490499 A CA490499 A CA 490499A CA 1248533 A CA1248533 A CA 1248533A
Authority
CA
Canada
Prior art keywords
formula
methyl
cyano
carbon atoms
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000490499A
Other languages
English (en)
French (fr)
Inventor
Herbert Leinert
Wolfgang Kampe
Klaus Strein
Beckmann Bernd Muller
Wolfgang Bartsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1248533A publication Critical patent/CA1248533A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA000490499A 1984-09-12 1985-09-11 Phenylacetonitrile derivatives Expired CA1248533A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843433383 DE3433383A1 (de) 1984-09-12 1984-09-12 Neue phenyl-acetonitril-derivate
DEP3433383.5 1984-09-12

Publications (1)

Publication Number Publication Date
CA1248533A true CA1248533A (en) 1989-01-10

Family

ID=6245162

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000490499A Expired CA1248533A (en) 1984-09-12 1985-09-11 Phenylacetonitrile derivatives

Country Status (16)

Country Link
US (1) US4612313A (index.php)
EP (1) EP0175249A3 (index.php)
JP (1) JPS6185355A (index.php)
AU (1) AU562730B2 (index.php)
CA (1) CA1248533A (index.php)
CS (1) CS255894B2 (index.php)
DD (1) DD237504A5 (index.php)
DE (1) DE3433383A1 (index.php)
DK (1) DK413685A (index.php)
ES (1) ES8604861A1 (index.php)
FI (1) FI853343L (index.php)
GR (1) GR852167B (index.php)
HU (1) HU195644B (index.php)
IL (1) IL76327A (index.php)
SU (1) SU1508956A3 (index.php)
ZA (1) ZA856942B (index.php)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612329A (en) * 1984-10-17 1986-09-16 Hokuriku Pharmaceutical Co., Ltd. Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
GB8717068D0 (en) * 1987-07-20 1987-08-26 Fujisawa Pharmaceutical Co Nitric ester derivative
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
US6263940B1 (en) 1999-04-21 2001-07-24 Axon Corporation In-line continuous feed sleeve labeling machine and method
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
PL2170050T3 (pl) * 2007-06-20 2014-12-31 Milestone Pharmaceuticals Inc Krótkodziałające fenyloalkiloaminowe blokery kanału wapniowego i ich zastosowania

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1154810B (de) 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
US4340603A (en) * 1980-08-13 1982-07-20 Interx Research Corporation Novel inotropic prodrugs
DE3144150A1 (de) * 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
FI853343A0 (fi) 1985-08-30
DK413685A (da) 1986-03-13
IL76327A0 (en) 1986-01-31
FI853343A7 (fi) 1986-03-13
EP0175249A2 (de) 1986-03-26
AU4709985A (en) 1986-03-20
DE3433383A1 (de) 1986-03-20
DK413685D0 (da) 1985-09-11
FI853343L (fi) 1986-03-13
GR852167B (index.php) 1986-01-03
JPS6185355A (ja) 1986-04-30
CS255894B2 (en) 1988-03-15
HUT38302A (en) 1986-05-28
IL76327A (en) 1989-06-30
CS652285A2 (en) 1987-07-16
US4612313A (en) 1986-09-16
ES546908A0 (es) 1986-03-16
ZA856942B (en) 1986-05-28
ES8604861A1 (es) 1986-03-16
SU1508956A3 (ru) 1989-09-15
AU562730B2 (en) 1987-06-18
EP0175249A3 (de) 1987-08-19
HU195644B (en) 1988-06-28
DD237504A5 (de) 1986-07-16

Similar Documents

Publication Publication Date Title
CA1180021A (en) Substituted carbamoyloxy derivatives of phenylethanolamine
US4731381A (en) Method of treating a person for sickle cell anemia
DE1957706C3 (de) Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis
US4602023A (en) Diphenic acid monoamides
EP0206567B1 (en) Compounds of formula [1,1'-biphenyl]-2-carboxylic acid, 2'-[[[(substituted)phenyl]-(substituted)amino]carbonyl]-, pharmaceutical compositions comprising the compounds, and a process for preparing the compounds
US4731473A (en) Compounds useful in treating sickle cell anemia
JP3236267B2 (ja) Ｎ−（カルバミイミドイルフェニル）グリシンアミド誘導体、その製造方法およびそれを含む医薬製剤
JP2005527621A (ja) アニリノ肝ｘ受容体調節因子
CA1181087A (en) Secondary amines, their preparation and use in pharmaceutical compositions
CA1248533A (en) Phenylacetonitrile derivatives
SI8711299A8 (en) Process for preparing new diphenylpropylamine derivatives
DE68917357T2 (de) Derivate der Coffeinsäure und pharmazeutische Zusammensetzungen, die sie enthalten.
KR850000872B1 (ko) 3-페녹시-1-알콕시카르보닐알킬아미노-프로판올-2 유도체의 제조 방법
JPH02500029A (ja) アリール‐ｎ‐アミノアルキル‐４‐（スルホンアミド）ベンズアミド、抗不整脈剤及びその組成物
DE2503222A1 (de) Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
US4840967A (en) Carbamate or urea derivatives, their preparation and pharmaceutical compositions comprising them
US4198419A (en) Phenylthiophenylpiperidines
FI74273C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 1-aryloxi-3-alkylamino-2-propanoler.
EP0330940A2 (de) Neue trisubstituierte Amine, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
JPS61140556A (ja) 新規なアリ−ル酢酸アニリド誘導体
DE60209122T2 (de) Bernsteinsäurederivate
US3996360A (en) Piperazine compounds
US3317526A (en) Omega-tertiaryamino butynol-1-phenylcycloalkane carboxylates
FI73665C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 1-(2-cyano-acylamino-fenyloxi)-3- (2-metylbutinyl-2)-2-propanoler.
EP0240256B1 (en) Compounds useful in treating sickle cell anemia

Legal Events

Date Code Title Description
MKEX Expiry