CA1243306A - Biologically active tripeptide and tetrapeptide alkylamides, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Biologically active tripeptide and tetrapeptide alkylamides, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
CA1243306A
CA1243306A CA000437638A CA437638A CA1243306A CA 1243306 A CA1243306 A CA 1243306A CA 000437638 A CA000437638 A CA 000437638A CA 437638 A CA437638 A CA 437638A CA 1243306 A CA1243306 A CA 1243306A
Authority
CA
Canada
Prior art keywords
ala
alanyl
proline
carbon atoms
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000437638A
Other languages
English (en)
French (fr)
Inventor
Jan Slaby
Alena Roubalova
Evzen Kasafirek
Premysl Fric
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Original Assignee
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Spojene Podniky Pro Zdravotnickou Vyrobu filed Critical Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Application granted granted Critical
Publication of CA1243306A publication Critical patent/CA1243306A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA000437638A 1982-10-01 1983-09-27 Biologically active tripeptide and tetrapeptide alkylamides, processes for the preparation thereof and pharmaceutical compositions containing the same Expired CA1243306A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS827013A CS231228B1 (en) 1982-10-01 1982-10-01 Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
CSPV7013-82 1982-10-01

Publications (1)

Publication Number Publication Date
CA1243306A true CA1243306A (en) 1988-10-18

Family

ID=5418471

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000437638A Expired CA1243306A (en) 1982-10-01 1983-09-27 Biologically active tripeptide and tetrapeptide alkylamides, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (13)

Country Link
US (1) US4528133A (cs)
JP (1) JPS5978150A (cs)
BE (1) BE897844A (cs)
CA (1) CA1243306A (cs)
CH (1) CH658251A5 (cs)
CS (1) CS231228B1 (cs)
DE (1) DE3335865A1 (cs)
FR (1) FR2533920B1 (cs)
GB (1) GB2127830B (cs)
HU (1) HU193048B (cs)
IT (1) IT1171092B (cs)
SE (1) SE457087B (cs)
YU (1) YU195383A (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
CZ285911B6 (cs) * 1997-04-30 1999-11-17 Vúfb, A. S. Oligopeptidické inhibitory elastáz
JP2000256396A (ja) 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
CA2378480A1 (en) * 1999-08-09 2001-02-15 Tripep Ab Pharmaceutical compositions containing tripeptides
MXPA02003672A (es) 1999-10-18 2002-08-30 Firmenich & Cie Esteres que comprenden una funcion carbamoilo secundaria y su utilizacion como precursores de alcoholes odorizantes.
US6593455B2 (en) * 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
EP1436317A1 (en) * 2001-09-19 2004-07-14 Tripep Ab Molecules that block viral infectivity and methods of use thereof
US20050096319A1 (en) * 2003-02-21 2005-05-05 Balzarini Jan M.R. Identification of compounds that inhibit replication of human immunodeficiency virus
PL378163A1 (pl) * 2003-02-21 2006-03-06 Tripep Ab Pochodna glicynoamidu do hamowania replikacji HIV
RU2255757C1 (ru) * 2004-06-22 2005-07-10 Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" Пептидное соединение, восстанавливающее функцию органов дыхания
WO2016044400A1 (en) * 2014-09-16 2016-03-24 Massachusetts Institute Of Technology Block copolymer complex coacervate core micelles for enzymatic catalysis in organic solvent
WO2017217855A1 (en) 2016-06-17 2017-12-21 Erasmus University Medical Center Rotterdam Geminoid lipopeptide compounds and their uses
EP4317280A1 (en) 2021-05-03 2024-02-07 Korea Research Institute of Chemical Technology Extractant and extraction method for removing color-expressing foreign substances from colored polymer containing ester functional group, and method for chemically selecting polymer containing ester functional group from colored polymer mixture

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972773A (en) * 1975-04-29 1976-08-03 Sagami Chemical Research Center Process for producing peptide
PH14141A (en) * 1976-06-25 1981-03-05 Hoffmann La Roche Pharmaceutical composition containing dipeptide derivatives
US4167449A (en) * 1976-07-29 1979-09-11 American Hospital Supply Corporation Composition and method for determining transferase and protease activity
US4155916A (en) * 1977-08-29 1979-05-22 Dolbeare Frank A Fluorescence method for enzyme analysis which couples aromatic amines with aromatic aldehydes
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
CS226907B1 (en) * 1981-08-07 1984-04-16 Kasafirek Evzen Alkylamides of carboxyalkanoylpeptides
US4371466A (en) * 1981-10-07 1983-02-01 American Home Products Corporation Mammalian collagenase inhibitors

Also Published As

Publication number Publication date
IT8323059A1 (it) 1985-03-29
JPH0359919B2 (cs) 1991-09-12
IT1171092B (it) 1987-06-10
JPS5978150A (ja) 1984-05-04
HU193048B (en) 1987-08-28
FR2533920B1 (fr) 1986-08-14
SE457087B (sv) 1988-11-28
US4528133A (en) 1985-07-09
SE8305123D0 (sv) 1983-09-22
DE3335865C2 (cs) 1991-03-14
YU195383A (en) 1986-08-31
FR2533920A1 (fr) 1984-04-06
SE8305123L (sv) 1984-04-02
CH658251A5 (de) 1986-10-31
GB8324970D0 (en) 1983-10-19
GB2127830B (en) 1986-08-13
DE3335865A1 (de) 1984-04-05
IT8323059A0 (it) 1983-09-29
GB2127830A (en) 1984-04-18
CS231228B1 (en) 1984-10-15
BE897844A (fr) 1984-01-16

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Legal Events

Date Code Title Description
MKEX Expiry