CA1237080A - Process for the production of camomile extracts rich in flavones - Google Patents
Process for the production of camomile extracts rich in flavonesInfo
- Publication number
- CA1237080A CA1237080A CA000476666A CA476666A CA1237080A CA 1237080 A CA1237080 A CA 1237080A CA 000476666 A CA000476666 A CA 000476666A CA 476666 A CA476666 A CA 476666A CA 1237080 A CA1237080 A CA 1237080A
- Authority
- CA
- Canada
- Prior art keywords
- camomile
- drug
- wing petals
- wing
- flavones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000284 extract Substances 0.000 title claims abstract description 24
- 229930003944 flavone Natural products 0.000 title claims abstract description 13
- 235000011949 flavones Nutrition 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 238000000034 method Methods 0.000 title claims description 10
- 150000002213 flavones Chemical class 0.000 title claims description 6
- 241000020115 Heterosperma pinnatum Species 0.000 claims abstract description 33
- 229940079593 drug Drugs 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 29
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 7
- 150000002212 flavone derivatives Chemical class 0.000 claims abstract description 7
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000000605 extraction Methods 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 20
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 19
- 235000008714 apigenin Nutrition 0.000 description 19
- 229940117893 apigenin Drugs 0.000 description 19
- 239000000341 volatile oil Substances 0.000 description 15
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 14
- 229930182478 glucoside Natural products 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 6
- -1 apigenin glucoside Chemical class 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 241001164374 Calyx Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229940126534 drug product Drugs 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 208000035199 Tetraploidy Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000003170 musculotropic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Gears, Cams (AREA)
- Cosmetics (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Paper (AREA)
- Seasonings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Catalysts (AREA)
- Pulleys (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Photoreceptors In Electrophotography (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Fats And Perfumes (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3409619.1 | 1984-03-16 | ||
| DE3409619 | 1984-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1237080A true CA1237080A (en) | 1988-05-24 |
Family
ID=6230658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000476666A Expired CA1237080A (en) | 1984-03-16 | 1985-03-15 | Process for the production of camomile extracts rich in flavones |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4786498A (en, 2012) |
| EP (1) | EP0154872B1 (en, 2012) |
| KR (1) | KR920010389B1 (en, 2012) |
| AT (1) | ATE58477T1 (en, 2012) |
| CA (1) | CA1237080A (en, 2012) |
| DE (2) | DE3580602D1 (en, 2012) |
| DK (1) | DK160229C (en, 2012) |
| ES (1) | ES541296A0 (en, 2012) |
| FI (1) | FI79468C (en, 2012) |
| GB (1) | GB2156674B (en, 2012) |
| GR (1) | GR850656B (en, 2012) |
| HK (1) | HK80591A (en, 2012) |
| IN (1) | IN163594B (en, 2012) |
| MA (1) | MA20376A1 (en, 2012) |
| MT (1) | MTP961B (en, 2012) |
| NL (1) | NL8500752A (en, 2012) |
| NO (1) | NO163214C (en, 2012) |
| PH (1) | PH24276A (en, 2012) |
| PT (1) | PT80103B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX161477A (es) * | 1984-09-19 | 1990-09-28 | Degussa | Procedimiento para extraer los constituyentes de la manzanilla |
| DE3542756C3 (de) * | 1984-12-19 | 1997-09-04 | Asta Medica Ag | Verfahren zur Herstellung einer neuen tetraploiden und bisabololreichen Kamille mit verbesserten Eigenschaften |
| US5108750A (en) * | 1986-09-08 | 1992-04-28 | Yaguang Liu | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation |
| US6300370B1 (en) | 1987-02-13 | 2001-10-09 | Asta Medica Aktiengesellschaft | Camomile oils having a high content of natural poly-ynes and process for their preparation |
| ES2044980T3 (es) * | 1987-02-13 | 1994-01-16 | Asta Medica Ag | Aceites de camomila con un elevado contenido de poliinas naturales y procedimiento para su preparacion. |
| DE3806210A1 (de) * | 1988-02-26 | 1989-09-07 | Robugen Gmbh | Kamille |
| DE4200555C2 (de) * | 1991-01-23 | 2003-02-27 | Viatris Gmbh | Herstellung eines Kamillenextraktes mit antimikrobiellen Eigenschaften |
| US5064675A (en) * | 1991-03-01 | 1991-11-12 | Scandinavian Natural Resources Development Hb | Herbal extract composition |
| US6409996B1 (en) * | 1997-11-19 | 2002-06-25 | Flavone Sunproducts A/S | Composition comprising one or more flavonoids, method of obtaining such composition and use thereof as UV-absorbing agent |
| US20040052880A1 (en) * | 2000-12-08 | 2004-03-18 | Yoshinori Kobayashi | Oral preparations having itching-relievign or antipruritic activity |
| KR102066388B1 (ko) * | 2018-03-09 | 2020-01-15 | 코스맥스엔에스 주식회사 | 캐모마일 추출물을 포함하는 근기능 및 운동능 강화 기능성 식품 조성물 및 그 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1015120A (fr) * | 1947-08-13 | 1952-08-27 | Procédé de préparation d'extraits actifs renfermant de l'azulène à partir de camomille ou de plantes analogues | |
| DE2331854A1 (de) * | 1973-06-22 | 1975-01-16 | Greither Salus Haus Dr Otto | Verfahren zur herstellung standardisierter arzneimittel aus kamillenblueten |
| DE2402802C3 (de) * | 1974-01-22 | 1979-06-13 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Gewinnung einer Kamillendroge mit hohem Chamazulen- und Bisabololgehalt |
| GB1560371A (en) * | 1978-03-17 | 1980-02-06 | Degussa | Process for obtaining a camomile drug |
| DE3105557A1 (de) * | 1981-02-16 | 1982-09-09 | Henkel Kgaa | "verfahren zur gewinnung von inhaltsstoffen der kamille durch extraktion mit kohlendioxid" |
| IT1157945B (it) * | 1982-06-02 | 1987-02-18 | Bonomelli Spa | Composizione terapeutica ad attivita' antibatterica a base di una frazione estratta da fiori di camomilla e processo per la preparazione di detta frazione |
| GB2167955B (en) * | 1983-06-29 | 1988-12-07 | Degussa | Preparation of camomile extracts and ethereal oils |
| DE3423207C3 (de) * | 1983-06-29 | 1996-09-26 | Asta Medica Ag | Verfahren zur Herstellung einer neuen Kamillensorte (Bezeichnung Manzana) |
| IT1177840B (it) * | 1983-06-29 | 1987-08-26 | Degussa | Procedimento per la produzione di una camomilla |
| DE3423307A1 (de) * | 1984-06-23 | 1986-01-02 | Daimler-Benz Ag, 7000 Stuttgart | Reifenfuelleinrichtung |
| MX161477A (es) * | 1984-09-19 | 1990-09-28 | Degussa | Procedimiento para extraer los constituyentes de la manzanilla |
-
1985
- 1985-02-22 IN IN128/CAL/85A patent/IN163594B/en unknown
- 1985-02-23 AT AT85102014T patent/ATE58477T1/de not_active IP Right Cessation
- 1985-02-23 DE DE8585102014T patent/DE3580602D1/de not_active Expired - Lifetime
- 1985-02-23 EP EP85102014A patent/EP0154872B1/de not_active Expired - Lifetime
- 1985-02-23 DE DE19853506467 patent/DE3506467A1/de not_active Withdrawn
- 1985-03-13 MA MA20600A patent/MA20376A1/fr unknown
- 1985-03-13 GB GB08506454A patent/GB2156674B/en not_active Expired
- 1985-03-14 PH PH31987A patent/PH24276A/en unknown
- 1985-03-14 GR GR850656A patent/GR850656B/el not_active IP Right Cessation
- 1985-03-14 PT PT80103A patent/PT80103B/pt unknown
- 1985-03-15 CA CA000476666A patent/CA1237080A/en not_active Expired
- 1985-03-15 NL NL8500752A patent/NL8500752A/nl not_active Application Discontinuation
- 1985-03-15 DK DK119985A patent/DK160229C/da not_active IP Right Cessation
- 1985-03-15 NO NO851043A patent/NO163214C/no not_active IP Right Cessation
- 1985-03-15 KR KR1019850001663A patent/KR920010389B1/ko not_active Expired
- 1985-03-15 ES ES541296A patent/ES541296A0/es active Granted
- 1985-03-15 FI FI851039A patent/FI79468C/fi not_active IP Right Cessation
- 1985-03-15 MT MT961A patent/MTP961B/xx unknown
-
1988
- 1988-02-02 US US07/153,481 patent/US4786498A/en not_active Expired - Lifetime
-
1991
- 1991-10-17 HK HK805/91A patent/HK80591A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE58477T1 (de) | 1990-12-15 |
| KR920010389B1 (ko) | 1992-11-27 |
| US4786498A (en) | 1988-11-22 |
| PH24276A (en) | 1990-05-29 |
| FI79468C (fi) | 1990-01-10 |
| GB8506454D0 (en) | 1985-04-17 |
| DK119985A (da) | 1985-09-17 |
| GB2156674A (en) | 1985-10-16 |
| PT80103A (de) | 1985-04-01 |
| DE3506467A1 (de) | 1985-09-19 |
| GB2156674B (en) | 1988-05-11 |
| DK119985D0 (da) | 1985-03-15 |
| FI79468B (fi) | 1989-09-29 |
| FI851039L (fi) | 1985-09-17 |
| DK160229C (da) | 1991-07-22 |
| DK160229B (da) | 1991-02-18 |
| FI851039A0 (fi) | 1985-03-15 |
| KR850006138A (ko) | 1985-10-02 |
| MA20376A1 (fr) | 1985-10-01 |
| IN163594B (en, 2012) | 1988-10-15 |
| NL8500752A (nl) | 1985-10-16 |
| NO851043L (no) | 1985-09-17 |
| DE3580602D1 (de) | 1991-01-03 |
| NO163214C (no) | 1990-04-25 |
| MTP961B (en) | 1985-11-25 |
| GR850656B (en, 2012) | 1985-07-11 |
| EP0154872A2 (de) | 1985-09-18 |
| ES8602416A1 (es) | 1985-12-01 |
| ES541296A0 (es) | 1985-12-01 |
| EP0154872A3 (en) | 1988-01-13 |
| EP0154872B1 (de) | 1990-11-22 |
| HK80591A (en) | 1991-10-25 |
| PT80103B (pt) | 1987-10-20 |
| NO163214B (no) | 1990-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |