CA1228542A - Lyophilized compositions, preparations and use thereof - Google Patents

Lyophilized compositions, preparations and use thereof

Info

Publication number
CA1228542A
CA1228542A CA000441247A CA441247A CA1228542A CA 1228542 A CA1228542 A CA 1228542A CA 000441247 A CA000441247 A CA 000441247A CA 441247 A CA441247 A CA 441247A CA 1228542 A CA1228542 A CA 1228542A
Authority
CA
Canada
Prior art keywords
syringe
powder
aminocaproic acid
mixture
slurry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000441247A
Other languages
English (en)
French (fr)
Inventor
Grace Wood
Benjamin R. Duce
Russell W. Pelham
James Woiszwillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serono Pharmaceutical Partners
Original Assignee
Serono Pharmaceutical Partners
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Pharmaceutical Partners filed Critical Serono Pharmaceutical Partners
Application granted granted Critical
Publication of CA1228542A publication Critical patent/CA1228542A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000441247A 1982-11-16 1983-11-15 Lyophilized compositions, preparations and use thereof Expired CA1228542A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/442,151 US4540410A (en) 1982-11-16 1982-11-16 Lyophilized compositions, preparation and use thereof
US442,151 1989-11-28

Publications (1)

Publication Number Publication Date
CA1228542A true CA1228542A (en) 1987-10-27

Family

ID=23755732

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000441247A Expired CA1228542A (en) 1982-11-16 1983-11-15 Lyophilized compositions, preparations and use thereof

Country Status (12)

Country Link
US (1) US4540410A (da)
EP (1) EP0109188B1 (da)
AT (1) ATE24838T1 (da)
AU (1) AU558164B2 (da)
CA (1) CA1228542A (da)
DE (1) DE3369070D1 (da)
DK (1) DK164538C (da)
ES (2) ES527289A0 (da)
IL (1) IL69923A (da)
NO (1) NO165625C (da)
PT (1) PT77621B (da)
ZA (1) ZA837407B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6144825A (ja) * 1984-08-09 1986-03-04 Unitika Ltd 止血剤
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
DE3816961A1 (de) * 1987-07-21 1989-02-02 Wasserburger Arzneimittelwerk Injektionsspritze fuer medizinische zwecke
EP0365704A1 (de) * 1988-10-26 1990-05-02 Zentralna Problemna Laboratoria Po Kryobiologia I Lyophilisazia Biopräparat für Hämostase bei Magenblutungen
US5063178A (en) * 1990-03-19 1991-11-05 Medex, Inc. Freeze-dried blood gas sensor
FR2694496A1 (fr) * 1992-08-05 1994-02-11 Bernstein Serge Procédé pour l'obtention d'un produit permettant l'expansion des seins et le traitement des rides.
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US6527738B1 (en) * 1999-04-30 2003-03-04 Prismedical Corporation Drug delivery pack
US20010037091A1 (en) * 1999-12-29 2001-11-01 Wironen John F. System for reconstituting pastes and methods of using same
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7101354B2 (en) 2004-05-03 2006-09-05 Infusive Technologies, Llc Mixing syringe with and without flush
US7998106B2 (en) 2004-05-03 2011-08-16 Thorne Jr Gale H Safety dispensing system for hazardous substances
BRPI0712088B8 (pt) * 2006-05-31 2021-06-22 Baxter Healthcare Sa uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido
EP1870649A1 (en) * 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
CA2703103C (en) 2007-10-30 2017-05-09 Baxter Healthcare S.A. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
EP2259803B2 (en) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
CN102802683B (zh) * 2009-06-16 2015-11-25 巴克斯特国际公司 止血海绵
US8771258B2 (en) 2009-12-16 2014-07-08 Baxter International Inc. Hemostatic sponge
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
BR112012030455B1 (pt) 2010-06-01 2021-08-17 Baxter Healthcare S.A. Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, e, kit para administrar uma composição hemostática
JP6289096B2 (ja) 2010-06-01 2018-03-07 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血組成物を作製するためのプロセス
MX345479B (es) * 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
WO2013053759A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
KR102135484B1 (ko) 2011-10-11 2020-07-20 백스터 인터내셔널 인코포레이티드 지혈 조성물
SA112330957B1 (ar) 2011-10-27 2015-08-09 باكستر انترناشونال انك. تركيبات لإيقاف النزف
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3316930B1 (en) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB450145A (en) * 1934-01-13 1936-07-06 Sharp & Dohme Inc Lyophilic biologically active substances and process of producing the same
GB455027A (en) * 1935-01-04 1935-08-01 Sharp & Dohme Inc Normal serum product and process of producing the same
US2380339A (en) * 1941-07-10 1945-07-10 Fromm Lab Inc Method and apparatus for preserving biological substances
US3743714A (en) * 1970-12-04 1973-07-03 Cis Radiopharmaceuticals Inc Novel carrier preparations for injectable radioactive compositions
US4006220A (en) * 1975-06-04 1977-02-01 Gottlieb Sheldon K Compositions and methods useful for repairing depressed cutaneous scars
US4191751A (en) * 1975-06-04 1980-03-04 Gottlieb Sheldon K Method for promoting growth of new connective tissue over surface wounds
US4167945A (en) * 1977-01-31 1979-09-18 Gottlieb Sheldon K Method for enhancing the healing of grafted tissue

Also Published As

Publication number Publication date
ES8600733A1 (es) 1985-11-01
EP0109188A1 (en) 1984-05-23
AU558164B2 (en) 1987-01-22
ATE24838T1 (de) 1987-01-15
AU2091683A (en) 1984-05-24
DK521283A (da) 1984-05-17
ES527289A0 (es) 1985-11-01
IL69923A (en) 1987-03-31
ES546583A0 (es) 1987-07-01
PT77621A (en) 1983-12-01
PT77621B (en) 1986-03-19
DK521283D0 (da) 1983-11-15
NO165625C (no) 1991-03-13
US4540410A (en) 1985-09-10
NO834183L (no) 1984-05-18
DK164538B (da) 1992-07-13
DK164538C (da) 1993-01-11
DE3369070D1 (en) 1987-02-19
ZA837407B (en) 1985-05-29
NO165625B (no) 1990-12-03
ES8706312A1 (es) 1987-07-01
EP0109188B1 (en) 1987-01-14

Similar Documents

Publication Publication Date Title
CA1228542A (en) Lyophilized compositions, preparations and use thereof
US10994045B2 (en) Process for making dry and stable hemostatic compositions
KR101865427B1 (ko) 건성의 안정된 지혈 조성물의 제조 방법
CA1217135A (en) Collagen-thrombin compositions
US5225205A (en) Pharmaceutical composition in the form of microparticles
US4191747A (en) Corrective agent for the covering and/or filling of bone defects, method for the preparation of same and method of using the same
Domb Long acting injectable oxytetracycline-liposphere formulations
US5597897A (en) Pharmaceutical formulations of osteogenic proteins
CA2264647C (en) Fragmented polymeric hydrogels for adhesion prevention and their preparation
US4855134A (en) Sustained-release preparation
EP0069260B1 (de) Wirkstoffhaltige Kollageneinlage zum Einführen in Knochen oder Weichteile und Verfahren zu deren Herstellung
EP0138216B1 (en) Sustained-release ifn preparation for parenteral administration
IE902592A1 (en) A method for preparing a sustained-release pharmaceutical peptide composition
AU2788592A (en) Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
EP1220693A1 (en) Formulations for delivery of osteogenic proteins
NZ215730A (en) Sustained-release peptide compositions containing proteins as carriers
JPH07503001A (ja) コラーゲンマイクロカプセル含有注射可能組成物
US3325366A (en) Biologically absorbable foam packing bandage and process therefor
KR20200105680A (ko) 분무-건조된 트롬빈, 및 분무-건조된 트롬빈의 사용 및 제조 방법
RU2123843C1 (ru) Состав для лечения ран различной этиологии
JPS61293925A (ja) 骨及び腱修復促進剤
BG62352B1 (bg) Ветеринарен препарат с продължително освобождаване, съдържащтилозин
RU2211708C2 (ru) Способ приготовления биоактивного костно-пластического материала "костма"

Legal Events

Date Code Title Description
MKEX Expiry