CA1221090A - Procede pour la preparation de sulfates de xylanes et les sulfates de xylanes ainsi obtenus - Google Patents
Procede pour la preparation de sulfates de xylanes et les sulfates de xylanes ainsi obtenusInfo
- Publication number
- CA1221090A CA1221090A CA000449345A CA449345A CA1221090A CA 1221090 A CA1221090 A CA 1221090A CA 000449345 A CA000449345 A CA 000449345A CA 449345 A CA449345 A CA 449345A CA 1221090 A CA1221090 A CA 1221090A
- Authority
- CA
- Canada
- Prior art keywords
- xylan
- sulfation
- solution
- sulfates
- percentage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 238000005194 fractionation Methods 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 19
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- 229920001221 xylan Polymers 0.000 claims description 68
- 150000004823 xylans Chemical class 0.000 claims description 64
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- 239000002253 acid Substances 0.000 claims description 23
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- -1 Xylan sulfates Chemical class 0.000 claims description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
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- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/14—Hemicellulose; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0057—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Xylans, i.e. xylosaccharide, e.g. arabinoxylan, arabinofuronan, pentosans; (beta-1,3)(beta-1,4)-D-Xylans, e.g. rhodymenans; Hemicellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8305170 | 1983-03-24 | ||
| FR8305170A FR2543145B1 (fr) | 1983-03-24 | 1983-03-24 | Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1221090A true CA1221090A (fr) | 1987-04-28 |
Family
ID=9287351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000449345A Expired CA1221090A (fr) | 1983-03-24 | 1984-03-12 | Procede pour la preparation de sulfates de xylanes et les sulfates de xylanes ainsi obtenus |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4699900A (en, 2012) |
| EP (1) | EP0125152B1 (en, 2012) |
| JP (1) | JPS6063203A (en, 2012) |
| KR (1) | KR860001394B1 (en, 2012) |
| AT (1) | ATE24520T1 (en, 2012) |
| AU (1) | AU561588B2 (en, 2012) |
| CA (1) | CA1221090A (en, 2012) |
| DE (1) | DE3461808D1 (en, 2012) |
| DK (1) | DK55784A (en, 2012) |
| ES (1) | ES8500962A1 (en, 2012) |
| FR (1) | FR2543145B1 (en, 2012) |
| GR (1) | GR79831B (en, 2012) |
| IL (1) | IL70846A0 (en, 2012) |
| NZ (1) | NZ207622A (en, 2012) |
| PT (1) | PT78179B (en, 2012) |
| ZA (1) | ZA842176B (en, 2012) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2543145B1 (fr) * | 1983-03-24 | 1986-10-17 | Sanofi Sa | Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante |
| FR2572731B1 (fr) * | 1984-11-07 | 1987-03-06 | Sanofi Sa | Nouveaux sulfates de xylanes de bas poids moleculaires, leur procede de preparation et leur activite antithrombotique et hypolipemiante par voie orale |
| FR2574663B1 (fr) * | 1984-12-17 | 1987-01-16 | Sanofi Sa | Nouvelle composition therapeutique a activite antithrombotique et hypolipemiante a base de xylanes et d'un acide organique |
| US4820693A (en) * | 1986-05-22 | 1989-04-11 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US4966890A (en) * | 1986-04-04 | 1990-10-30 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| DE3917982A1 (de) * | 1989-06-02 | 1990-12-06 | Behringwerke Ag | Verwendung von xylanpolyhydrogensulfaten zur therapie von zellproliferations-bedingten erkrankungen |
| FR2655267B1 (fr) * | 1989-12-04 | 1992-04-03 | Roussel Uclaf | Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant. |
| US5141928B1 (en) * | 1989-12-20 | 1995-11-14 | Brujo Inc | Ophthalmic medication |
| US5382570A (en) * | 1990-04-23 | 1995-01-17 | Akzo, N.V. | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
| US5378829A (en) * | 1990-04-23 | 1995-01-03 | Akzo N.V. | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type |
| US5668274A (en) * | 1991-04-23 | 1997-09-16 | Akzo Nobel N.V. | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
| IL102758A (en) * | 1991-08-23 | 1997-03-18 | Akzo Nv | Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them |
| US5639469A (en) * | 1994-06-15 | 1997-06-17 | Minnesota Mining And Manufacturing Company | Transmucosal delivery system |
| US6255295B1 (en) | 1996-12-23 | 2001-07-03 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue |
| US20070141181A1 (en) * | 1998-02-13 | 2007-06-21 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
| US6797289B2 (en) * | 1998-02-13 | 2004-09-28 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
| US6451771B1 (en) | 1999-02-12 | 2002-09-17 | Nutramax Laboratories, Inc. | Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals |
| ES2251289B1 (es) * | 2004-02-27 | 2007-07-01 | Bioiberica, S.A. | Nuevo uso terapeutico de un grupo de polisacaridos sulfatados. |
| WO2009047699A1 (en) * | 2007-10-10 | 2009-04-16 | Alembic Limited | An improved process for the preparation of an amorphous form of pentosan polysulfate or salts thereof |
| AU2008100725B4 (en) * | 2008-07-04 | 2008-10-02 | Parnell Technologies Pty Ltd | A sulfated polysaccharide compound for clinical use |
| WO2011088418A2 (en) * | 2010-01-15 | 2011-07-21 | Mount Sinai School Of Medicine | Inhibition of tnf-alpha induced activation of nfkb by pentosan polysulfate |
| WO2012101544A1 (en) * | 2011-01-29 | 2012-08-02 | Alembic Pharmaceuticals Limited | An improved process for the preparation of pentosan polysulfate or salts thereof |
| WO2012114349A1 (en) * | 2011-02-23 | 2012-08-30 | Cadila Healthcare Limited | An improved process for the preparation of pentosan polysulfate sodium |
| JP6225321B1 (ja) | 2016-08-31 | 2017-11-08 | 王子ホールディングス株式会社 | ポリ硫酸ペントサンの製造方法 |
| BR112020003908B1 (pt) | 2016-08-31 | 2023-01-24 | Oji Holdings Corporation | Método para produzir um ingrediente farmacêutico ativo incluindo polissulfato de pentosano |
| JP6281659B1 (ja) | 2017-02-28 | 2018-02-21 | 王子ホールディングス株式会社 | ポリ硫酸ペントサン、医薬組成物及び抗凝固剤 |
| MX390883B (es) | 2017-05-31 | 2025-03-21 | Oji Holdings Corp | Preparacion hidratante topica |
| BR112020004787A2 (pt) | 2017-09-12 | 2020-09-24 | Oji Holdings Corporation | polissulfato de pentosano, composição farmacêutica, anticoagulante, e, método para produzir polissulfato de pentosano |
| PT3730521T (pt) * | 2017-12-20 | 2023-06-19 | Oji Holdings Corp | Polissulfato de pentosano e medicamento contendo polissulfato de pentosano |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH290145A (de) * | 1944-06-13 | 1953-04-15 | Kaulla Kurt Nikolai Dr Med Von | Verfahren zur Herstellung von Schwefelsäureestern des Xylans. |
| FR1050576A (fr) * | 1951-02-06 | 1954-01-08 | Wander Ag Dr A | Procédé pour la préparation de sels alcalins de l'ester sulfurique du xylane |
| US3290263A (en) * | 1962-08-02 | 1966-12-06 | Colonial Sugar Refining Co | Process of reacting sugars with reagents wherein the sugar is dissolved in monohydric alcohols containing grouping |
| ES343957A1 (es) * | 1967-08-09 | 1968-10-01 | Rocador Sa | Procedimiento de obtencion de polisacaridos sulfatados an- tilipemicos activos por via oral. |
| US4098995A (en) * | 1976-07-12 | 1978-07-04 | American Cyanamid Company | Polygalactosido-sucrose poly(h-)sulfate salts |
| US4301153A (en) * | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
| US4122250A (en) * | 1977-08-22 | 1978-10-24 | Gottfried Schmer | Separation of high-activity heparin by affinity chromatography |
| US4221907A (en) * | 1979-07-09 | 1980-09-09 | American Cyanamid Company | Substituted O-α-D and O-β-D-multi-galactopyranosyl and glucopyranosyl 1→4 and 1→6 galactopyranosyl 1→6 α-D-glucopyranoses |
| DE2945595A1 (de) * | 1979-11-12 | 1981-05-21 | Sandoz-Patent-GmbH, 7850 Lörrach | Verfahren zur herstellung von niedermolekularem heparin bzw. seinen salzen |
| US4281108A (en) * | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
| FR2543145B1 (fr) * | 1983-03-24 | 1986-10-17 | Sanofi Sa | Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante |
-
1983
- 1983-03-24 FR FR8305170A patent/FR2543145B1/fr not_active Expired
-
1984
- 1984-02-01 IL IL70846A patent/IL70846A0/xx unknown
- 1984-02-08 DK DK55784A patent/DK55784A/da not_active Application Discontinuation
- 1984-02-09 AU AU24412/84A patent/AU561588B2/en not_active Ceased
- 1984-03-01 PT PT78179A patent/PT78179B/pt unknown
- 1984-03-02 ES ES530266A patent/ES8500962A1/es not_active Expired
- 1984-03-02 GR GR73987A patent/GR79831B/el unknown
- 1984-03-05 DE DE8484400438T patent/DE3461808D1/de not_active Expired
- 1984-03-05 AT AT84400438T patent/ATE24520T1/de not_active IP Right Cessation
- 1984-03-05 EP EP84400438A patent/EP0125152B1/fr not_active Expired
- 1984-03-12 CA CA000449345A patent/CA1221090A/fr not_active Expired
- 1984-03-21 KR KR1019840001491A patent/KR860001394B1/ko not_active Expired
- 1984-03-23 US US06/592,527 patent/US4699900A/en not_active Expired - Fee Related
- 1984-03-23 NZ NZ207622A patent/NZ207622A/en unknown
- 1984-03-23 ZA ZA842176A patent/ZA842176B/xx unknown
- 1984-03-24 JP JP59057193A patent/JPS6063203A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ207622A (en) | 1986-08-08 |
| DE3461808D1 (en) | 1987-02-05 |
| IL70846A0 (en) | 1984-05-31 |
| ZA842176B (en) | 1984-10-31 |
| EP0125152B1 (fr) | 1986-12-30 |
| KR840008376A (ko) | 1984-12-14 |
| US4699900A (en) | 1987-10-13 |
| AU561588B2 (en) | 1987-05-14 |
| DK55784A (da) | 1984-09-25 |
| ES530266A0 (es) | 1984-11-01 |
| ES8500962A1 (es) | 1984-11-01 |
| KR860001394B1 (ko) | 1986-09-22 |
| DK55784D0 (da) | 1984-02-08 |
| AU2441284A (en) | 1984-09-27 |
| JPS6063203A (ja) | 1985-04-11 |
| FR2543145A1 (fr) | 1984-09-28 |
| FR2543145B1 (fr) | 1986-10-17 |
| EP0125152A1 (fr) | 1984-11-14 |
| ATE24520T1 (de) | 1987-01-15 |
| PT78179B (fr) | 1986-04-24 |
| GR79831B (en, 2012) | 1984-10-31 |
| PT78179A (fr) | 1984-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |