CA1202309A - Aurore derivatives - Google Patents

Aurore derivatives

Info

Publication number
CA1202309A
CA1202309A CA000335522A CA335522A CA1202309A CA 1202309 A CA1202309 A CA 1202309A CA 000335522 A CA000335522 A CA 000335522A CA 335522 A CA335522 A CA 335522A CA 1202309 A CA1202309 A CA 1202309A
Authority
CA
Canada
Prior art keywords
hydrogen
carboxyl
halogen
nitro
chcooh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000335522A
Other languages
English (en)
French (fr)
Inventor
Stephen R. Baker
William J. Ross
William B. Jamieson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of CA1202309A publication Critical patent/CA1202309A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000335522A 1978-09-13 1979-09-12 Aurore derivatives Expired CA1202309A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7836705 1978-09-13
GB36705/78 1978-09-13

Publications (1)

Publication Number Publication Date
CA1202309A true CA1202309A (en) 1986-03-25

Family

ID=10499649

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000335522A Expired CA1202309A (en) 1978-09-13 1979-09-12 Aurore derivatives

Country Status (29)

Country Link
US (1) USRE32196E (cs)
JP (1) JPS5540692A (cs)
KR (1) KR830001919B1 (cs)
AR (2) AR228020A1 (cs)
AT (1) AT376968B (cs)
AU (1) AU535369B2 (cs)
BG (2) BG43187A3 (cs)
CA (1) CA1202309A (cs)
CH (1) CH644603A5 (cs)
CS (1) CS214806B2 (cs)
DD (1) DD146046A5 (cs)
DK (1) DK382579A (cs)
EG (1) EG14105A (cs)
ES (1) ES484115A1 (cs)
FI (1) FI792850A (cs)
GR (1) GR71200B (cs)
HU (1) HU181450B (cs)
IE (1) IE48824B1 (cs)
IL (1) IL58229A (cs)
IT (1) IT1162395B (cs)
MX (1) MX6232E (cs)
NZ (1) NZ191556A (cs)
PH (1) PH15712A (cs)
PL (1) PL124296B1 (cs)
PT (1) PT70170A (cs)
SE (1) SE447382B (cs)
SU (1) SU1138027A3 (cs)
YU (1) YU222079A (cs)
ZA (1) ZA794836B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307070B1 (en) 1996-01-26 2001-10-23 Phytera, Inc. Substituted aurone derivatives
WO1997026873A1 (en) * 1996-01-26 1997-07-31 Phytera, Inc. Antimicrobial aurone derivatives
JP2001510801A (ja) * 1997-07-25 2001-08-07 フィテラ インク． 置換アウロン誘導体
JP4166433B2 (ja) * 1997-09-11 2008-10-15 第一製薬株式会社 ホルモン依存性疾患治療剤
JP2003524648A (ja) 2000-01-28 2003-08-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ベンゾフラノン誘導体を含む酸化ストレスに対する保護用の配合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT277985B (de) * 1967-11-14 1970-01-12 Schering Ag Verfahren zur Herstellung von neuen Nitro-furan-, -thiophen- oder -pyrrol-derivaten
US4115567A (en) * 1973-12-27 1978-09-19 Carlo Erba S. P. A. 6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof
US3975380A (en) * 1974-06-03 1976-08-17 Smithkline Corporation Substituted aurones
US4067993A (en) * 1975-09-24 1978-01-10 Riker Laboratories, Inc. Antimicrobial 2-nitro-3-phenylbenzofurancarboxylic acids
US4143145A (en) * 1977-01-12 1979-03-06 Carlo Erba S. P. A. Substituted 2-vinyl-chromones and process for their preparation
FR2396756A1 (fr) * 1977-07-06 1979-02-02 Inst Nat Sante Rech Med Nouvelles benzylidene-2-benzofurannones-3, leur obtention et leur application a titre de medicaments
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4143055A (en) * 1978-03-27 1979-03-06 Gruppo Lepetit S.P.A. 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives

Also Published As

Publication number Publication date
IL58229A (en) 1984-05-31
PH15712A (en) 1983-03-14
MX6232E (es) 1985-01-14
SE7907532L (sv) 1980-03-14
CH644603A5 (en) 1984-08-15
GR71200B (cs) 1983-04-11
BG40315A3 (en) 1986-11-14
ZA794836B (en) 1981-03-25
IL58229A0 (en) 1979-12-30
BG43187A3 (en) 1988-04-15
SE447382B (sv) 1986-11-10
AR228020A1 (es) 1983-01-14
KR830001919B1 (ko) 1983-09-23
PL218277A1 (cs) 1980-07-14
DD146046A5 (de) 1981-01-21
PT70170A (en) 1979-10-01
CS214806B2 (en) 1982-06-25
SU1138027A3 (ru) 1985-01-30
IT1162395B (it) 1987-03-25
IT7950245A0 (it) 1979-09-12
AT376968B (de) 1985-01-25
AU535369B2 (en) 1984-03-15
YU222079A (en) 1983-02-28
AR226210A1 (es) 1982-06-15
FI792850A (fi) 1980-03-14
IE48824B1 (en) 1985-05-29
ATA598079A (de) 1984-06-15
AU5078079A (en) 1980-03-20
JPS5540692A (en) 1980-03-22
PL124296B1 (en) 1983-01-31
ES484115A1 (es) 1980-04-16
DK382579A (da) 1980-03-14
USRE32196E (en) 1986-07-01
NZ191556A (en) 1981-03-16
HU181450B (en) 1983-07-28
IE791729L (en) 1980-03-13
EG14105A (en) 1983-03-31

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Legal Events

Date Code Title Description
MKEX Expiry