IE791729L - Aurone derivatives - Google Patents
Aurone derivativesInfo
- Publication number
- IE791729L IE791729L IE791729A IE172979A IE791729L IE 791729 L IE791729 L IE 791729L IE 791729 A IE791729 A IE 791729A IE 172979 A IE172979 A IE 172979A IE 791729 L IE791729 L IE 791729L
- Authority
- IE
- Ireland
- Prior art keywords
- chcooh
- tetrazol
- carboxyl
- aurone derivatives
- ch644603a5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The substituted aurones correspond to the formula: <IMAGE> where R<1>, R<2>, R<3>, R<4>, R<5> and R<6> = H, halogen, C1-6 alkyl, C 1-6 alkoxy, C3-8 cycloalkyl, optionally substituted phenyl, C1-6 haloalkyl, amido, amino, cyano, hydroxyl, nitro, C2-4 alkenyl, carboxyl, tetrazol-5-yl and -CH=CHCOOH, or R<1> and R<2> together = -CH=CH-CH=CH-, provided that at least one of the radicals R<1>, R<2>, R<3>, R<4>, R<5> and R<6> = carboxyl, tetrazol-5-yl or -CH=CHCOOH. The compounds can be used for the prophylactic chemotherapy of allergic states such as bronchial asthma.
[CH644603A5]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7836705 | 1978-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791729L true IE791729L (en) | 1980-03-13 |
| IE48824B1 IE48824B1 (en) | 1985-05-29 |
Family
ID=10499649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1729/79A IE48824B1 (en) | 1978-09-13 | 1979-09-12 | Aurone derivatives |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | USRE32196E (en) |
| JP (1) | JPS5540692A (en) |
| KR (1) | KR830001919B1 (en) |
| AR (2) | AR228020A1 (en) |
| AT (1) | AT376968B (en) |
| AU (1) | AU535369B2 (en) |
| BG (2) | BG43187A3 (en) |
| CA (1) | CA1202309A (en) |
| CH (1) | CH644603A5 (en) |
| CS (1) | CS214806B2 (en) |
| DD (1) | DD146046A5 (en) |
| DK (1) | DK382579A (en) |
| EG (1) | EG14105A (en) |
| ES (1) | ES484115A1 (en) |
| FI (1) | FI792850A (en) |
| GR (1) | GR71200B (en) |
| HU (1) | HU181450B (en) |
| IE (1) | IE48824B1 (en) |
| IL (1) | IL58229A (en) |
| IT (1) | IT1162395B (en) |
| MX (1) | MX6232E (en) |
| NZ (1) | NZ191556A (en) |
| PH (1) | PH15712A (en) |
| PL (1) | PL124296B1 (en) |
| PT (1) | PT70170A (en) |
| SE (1) | SE447382B (en) |
| SU (1) | SU1138027A3 (en) |
| YU (1) | YU222079A (en) |
| ZA (1) | ZA794836B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6307070B1 (en) | 1996-01-26 | 2001-10-23 | Phytera, Inc. | Substituted aurone derivatives |
| WO1997026873A1 (en) * | 1996-01-26 | 1997-07-31 | Phytera, Inc. | Antimicrobial aurone derivatives |
| JP2001510801A (en) * | 1997-07-25 | 2001-08-07 | フィテラ インク． | Substituted aurone derivatives |
| JP4166433B2 (en) * | 1997-09-11 | 2008-10-15 | 第一製薬株式会社 | Hormone-dependent disease treatment |
| US6903134B2 (en) | 2000-01-28 | 2005-06-07 | Merck Patent Gmbh | Formulation comprising benzofuranone derivatives for protection against oxidative stress |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT277985B (en) * | 1967-11-14 | 1970-01-12 | Schering Ag | Process for the preparation of new nitro-furan, -thiophene or -pyrrole derivatives |
| US4115567A (en) * | 1973-12-27 | 1978-09-19 | Carlo Erba S. P. A. | 6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof |
| US3975380A (en) * | 1974-06-03 | 1976-08-17 | Smithkline Corporation | Substituted aurones |
| US4067993A (en) * | 1975-09-24 | 1978-01-10 | Riker Laboratories, Inc. | Antimicrobial 2-nitro-3-phenylbenzofurancarboxylic acids |
| US4143145A (en) * | 1977-01-12 | 1979-03-06 | Carlo Erba S. P. A. | Substituted 2-vinyl-chromones and process for their preparation |
| FR2396756A1 (en) * | 1977-07-06 | 1979-02-02 | Inst Nat Sante Rech Med | NEW BENZYLIDENE-2-BENZOFURANNONES-3, THEIR OBTAINING AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| IT1093805B (en) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | DERIVATIVES OF 2H-BENZOFURAN-3-ONE AND PROCEDURE FOR THEIR PREPARATION |
| US4143055A (en) * | 1978-03-27 | 1979-03-06 | Gruppo Lepetit S.P.A. | 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives |
-
1979
- 1979-09-11 EG EG544/79A patent/EG14105A/en active
- 1979-09-11 AR AR278010A patent/AR228020A1/en active
- 1979-09-11 SE SE7907532A patent/SE447382B/en not_active IP Right Cessation
- 1979-09-11 GR GR60011A patent/GR71200B/el unknown
- 1979-09-11 CH CH820379A patent/CH644603A5/en not_active IP Right Cessation
- 1979-09-11 IL IL58229A patent/IL58229A/en unknown
- 1979-09-11 AT AT0598079A patent/AT376968B/en not_active IP Right Cessation
- 1979-09-12 ES ES484115A patent/ES484115A1/en not_active Expired
- 1979-09-12 PT PT70170A patent/PT70170A/en unknown
- 1979-09-12 BG BG044838A patent/BG43187A3/en unknown
- 1979-09-12 SU SU792816201A patent/SU1138027A3/en active
- 1979-09-12 IE IE1729/79A patent/IE48824B1/en unknown
- 1979-09-12 AU AU50780/79A patent/AU535369B2/en not_active Ceased
- 1979-09-12 PH PH23026A patent/PH15712A/en unknown
- 1979-09-12 IT IT50245/79A patent/IT1162395B/en active
- 1979-09-12 ZA ZA00794836A patent/ZA794836B/en unknown
- 1979-09-12 NZ NZ191556A patent/NZ191556A/en unknown
- 1979-09-12 HU HU79LI349A patent/HU181450B/en unknown
- 1979-09-12 DD DD79215501A patent/DD146046A5/en unknown
- 1979-09-12 YU YU02220/79A patent/YU222079A/en unknown
- 1979-09-12 BG BG046265A patent/BG40315A3/en unknown
- 1979-09-12 CA CA000335522A patent/CA1202309A/en not_active Expired
- 1979-09-12 DK DK382579A patent/DK382579A/en not_active Application Discontinuation
- 1979-09-12 MX MX798376U patent/MX6232E/en unknown
- 1979-09-13 KR KR1019790003145A patent/KR830001919B1/en active
- 1979-09-13 JP JP11781279A patent/JPS5540692A/en active Pending
- 1979-09-13 CS CS796201A patent/CS214806B2/en unknown
- 1979-09-13 PL PL1979218277A patent/PL124296B1/en unknown
- 1979-09-13 FI FI792850A patent/FI792850A/en not_active Application Discontinuation
-
1981
- 1981-05-06 AR AR285217A patent/AR226210A1/en active
-
1982
- 1982-05-19 US US06/379,793 patent/USRE32196E/en not_active Expired - Lifetime
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