JPS5758677A - Germanium compound of thiazolidine derivative and its preparation - Google Patents
Germanium compound of thiazolidine derivative and its preparationInfo
- Publication number
- JPS5758677A JPS5758677A JP55133182A JP13318280A JPS5758677A JP S5758677 A JPS5758677 A JP S5758677A JP 55133182 A JP55133182 A JP 55133182A JP 13318280 A JP13318280 A JP 13318280A JP S5758677 A JPS5758677 A JP S5758677A
- Authority
- JP
- Japan
- Prior art keywords
- thiazolidine derivative
- preparation
- germanium compound
- formulai
- antihypotensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003548 thiazolidines Chemical class 0.000 title abstract 3
- 150000002291 germanium compounds Chemical class 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 229940124572 antihypotensive agent Drugs 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229910000078 germane Inorganic materials 0.000 abstract 1
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium oxide Inorganic materials O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000005555 hypertensive agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- PVADDRMAFCOOPC-UHFFFAOYSA-N oxogermanium Chemical compound [Ge]=O PVADDRMAFCOOPC-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Abstract
NEW MATERIAL:A germanium compound of thiazolidine derivative shown by the formulaI[R1 is hydroxyl group, lower alkoxy, or amino; R2 is H, or phenyl which may have substituent group (OH, acyloxy); R3 is H or lower alkyl].
EXAMPLE: Tetra[3-(4-carboxy-3-thiazolidinyl)-3-oxopropylmercapto] germane.
USE: Having strong inhibitory actions on an enzyme capable of converting antiotensinI, exhibiting antihypotensive actions, useful as an antihypotensive agent.
PROCESS: A thiazolidine derivative shown by the formula II is reacted with germanium oxide in an aqueous medium, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55133182A JPS5758677A (en) | 1980-09-25 | 1980-09-25 | Germanium compound of thiazolidine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55133182A JPS5758677A (en) | 1980-09-25 | 1980-09-25 | Germanium compound of thiazolidine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5758677A true JPS5758677A (en) | 1982-04-08 |
Family
ID=15098596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55133182A Pending JPS5758677A (en) | 1980-09-25 | 1980-09-25 | Germanium compound of thiazolidine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5758677A (en) |
-
1980
- 1980-09-25 JP JP55133182A patent/JPS5758677A/en active Pending
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