CA1196635A - 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them - Google Patents

7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them

Info

Publication number
CA1196635A
CA1196635A CA000412319A CA412319A CA1196635A CA 1196635 A CA1196635 A CA 1196635A CA 000412319 A CA000412319 A CA 000412319A CA 412319 A CA412319 A CA 412319A CA 1196635 A CA1196635 A CA 1196635A
Authority
CA
Canada
Prior art keywords
compound
formula
dihydro
bromo
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000412319A
Other languages
English (en)
French (fr)
Inventor
Horst Zeugner
Michael Ruhland
Hans Liepmann
Wolfgang Milkowski
Herbert Musch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to CA000462932A priority Critical patent/CA1196634A/en
Application granted granted Critical
Publication of CA1196635A publication Critical patent/CA1196635A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA000412319A 1981-09-30 1982-09-28 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them Expired CA1196635A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000462932A CA1196634A (en) 1981-09-30 1984-09-11 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813138769 DE3138769A1 (de) 1981-09-30 1981-09-30 7-brom-5-(2-halogenphenyl)-1h-2,3-dihydro-1,4- benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DEP3138769.1 1981-09-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000462932A Division CA1196634A (en) 1981-09-30 1984-09-11 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CA1196635A true CA1196635A (en) 1985-11-12

Family

ID=6142952

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000412319A Expired CA1196635A (en) 1981-09-30 1982-09-28 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4505908A (enExample)
EP (1) EP0075855B1 (enExample)
JP (1) JPS5867678A (enExample)
AT (1) ATE17123T1 (enExample)
AU (1) AU553689B2 (enExample)
CA (1) CA1196635A (enExample)
DD (1) DD203907A5 (enExample)
DE (2) DE3138769A1 (enExample)
DK (1) DK156065C (enExample)
ES (1) ES515774A0 (enExample)
FI (1) FI68047C (enExample)
GR (1) GR77652B (enExample)
HU (1) HU189179B (enExample)
IE (1) IE53937B1 (enExample)
IL (1) IL66890A (enExample)
NO (1) NO157698C (enExample)
NZ (1) NZ202036A (enExample)
PH (1) PH18102A (enExample)
PT (1) PT75553B (enExample)
ZA (1) ZA827140B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3221402A1 (de) * 1982-06-05 1983-12-08 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-phenyl-1,4-benzodiazepine enthaltende analgetisch wirksame pharmazeutische zubereitungen
CN1165525C (zh) * 1999-08-27 2004-09-08 宝洁公司 漂白增效剂组分、组合物及洗涤方法
US6818607B1 (en) * 1999-08-27 2004-11-16 Procter & Gamble Company Bleach boosting components, compositions and laundry methods
US6821935B1 (en) 1999-08-27 2004-11-23 Procter & Gamble Company Color safe laundry methods employing zwitterionic formulation components
MXPA02002129A (es) * 1999-08-27 2002-09-18 Procter & Gamble Componentes de formulacion de accion rapida, composiciones y metodos para lavanderia que los emplean.
US7109156B1 (en) 1999-08-27 2006-09-19 Procter & Gamble Company Controlled availability of formulation components, compositions and laundry methods employing same
US6825160B1 (en) 1999-08-27 2004-11-30 Procter & Gamble Company Color safe laundry methods employing cationic formulation components
US6903060B1 (en) 1999-08-27 2005-06-07 Procter & Gamble Company Stable formulation components, compositions and laundry methods employing same
JP2003508587A (ja) 1999-08-27 2003-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー 安定性増強配合成分、これを用いた組成物および洗濯方法
US7169744B2 (en) * 2002-06-06 2007-01-30 Procter & Gamble Company Organic catalyst with enhanced solubility
US7557076B2 (en) * 2002-06-06 2009-07-07 The Procter & Gamble Company Organic catalyst with enhanced enzyme compatibility
US20050113246A1 (en) * 2003-11-06 2005-05-26 The Procter & Gamble Company Process of producing an organic catalyst
AR051659A1 (es) * 2005-06-17 2007-01-31 Procter & Gamble Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244869A (en) * 1972-05-03 1981-01-13 Kali-Chemie A.G. Benzodiazepine derivatives and process of making them
DE2265370C2 (de) * 1972-05-03 1982-12-02 Kali-Chemie Ag, 3000 Hannover 6-Phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocinderivate
DE2520937C3 (de) * 1975-05-10 1978-10-12 Kali-Chemie Ag, 3000 Hannover 7-Brom-1 -methyl^-alkoxymethyl-S-(2-halogenphenyl)-lH-23-dihydro-l,4benzodiazepinderivate, deren Säureadditionssalze und pharmazeutische Präparate
DE2353160C2 (de) * 1973-05-02 1986-07-17 Kali-Chemie Ag, 3000 Hannover 5-Phenyl-2,3-dihydro-1H-1,4-benzodiazepine, ihre Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
IL66890A (en) 1985-11-29
IE53937B1 (en) 1989-04-26
DK156065C (da) 1989-11-13
DE3138769A1 (de) 1983-04-14
IL66890A0 (en) 1982-12-31
PT75553B (en) 1984-12-12
FI68047B (fi) 1985-03-29
HU189179B (en) 1986-06-30
ZA827140B (en) 1983-07-27
US4505908A (en) 1985-03-19
DK431782A (da) 1983-03-31
JPH0433791B2 (enExample) 1992-06-04
ES8306126A1 (es) 1983-05-01
DE3268156D1 (en) 1986-02-06
DK156065B (da) 1989-06-19
DD203907A5 (de) 1983-11-09
NZ202036A (en) 1985-02-28
EP0075855B1 (de) 1985-12-27
EP0075855A2 (de) 1983-04-06
FI823338A0 (fi) 1982-09-29
FI68047C (fi) 1985-07-10
NO823265L (no) 1983-04-05
JPS5867678A (ja) 1983-04-22
EP0075855A3 (en) 1983-06-15
PH18102A (en) 1985-03-20
ATE17123T1 (de) 1986-01-15
IE822362L (en) 1983-03-30
AU553689B2 (en) 1986-07-24
GR77652B (enExample) 1984-09-25
PT75553A (en) 1982-10-01
NO157698B (no) 1988-01-25
AU8883882A (en) 1983-04-14
NO157698C (no) 1988-05-04
FI823338L (fi) 1983-03-31
ES515774A0 (es) 1983-05-01

Similar Documents

Publication Publication Date Title
US4614740A (en) 5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same
US4505908A (en) 7-Bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepine pharmaceuticals
SU1029827A3 (ru) Способ получени меркаптозамещенных 2,3,4,5-тетрагидро-1 @ -3-бензазепинов или их солей
CA1169425A (en) 2-acylaminomethyl-1,4-benzodiazepines and their salts as well as the preparation thereof, and use of pharmaceutical compositions containing these compounds
US4096261A (en) Dibenzodiazepines
DE2262653A1 (de) Neue 7-substituierte 3,5-dihydro-astriazino- eckige klammer auf 4,3-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepine, deren 6-oxyde und verfahren zu ihrer herstellung
US4191760A (en) Dibenzodiazepines
CA1063605A (en) Benzodiazepine derivatives and a process for the preparation thereof
US4587245A (en) Method of treating neuropsychic disturbances by benzodiazepine derivatives and composition therefor
US3757008A (en) Sses for preparing same 1 - (carboxyl-heteroalkyl) - 1,4-benzodiazepine derivatives and proce
US4533662A (en) 2-Acylaminomethyl-1,4-benzodiazepine compounds and analgesic use
US3947408A (en) Pyrrolo-benzodiazepines, method of preparation and method of use
WO1993017012A1 (en) 2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutically acceptable acid addition salts thereof
US3985732A (en) 1,2,3,11A-Tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5,11(10H)-diones
CA1196634A (en) 7-bromo-5-(2-halophenyl)-1h-2,3-dihydro-1,4- benzodiazepine compounds, method for their manufacture and pharmaceutical compositions containing them
Ning et al. Quinazolines and 1, 4-benzodiazepines. 58. Azido group, a novel pharmacophoric substituent. 7-Azido-5-phenyl-1, 4-benzodiazepines
EP2029555A2 (fr) Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur préparation, compositions les contenant et utilisation
US4178378A (en) Etherified triazolobenzodiazepine derivatives
US3946032A (en) Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde
EP0726257B1 (en) 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation
PL115163B1 (en) Process for preparing novel triazolothienodiazepin-1-ones
DK145930B (da) Fremgangsmaade til fremstilling af 2-substituerede 1,4-benzodiazepinderivater eller syreadditionssalte deraf
US3968230A (en) Compositions containing benzodiazepindiones and method of use
GB2046254A (en) Benzodiazepines
DK154432B (da) Analogifremgangsmaade til fremstilling af (1,2)-anellerede 7-phenyl-1,4-benzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf

Legal Events

Date Code Title Description
MKEX Expiry