CA1195250A - Solid shaped articles - Google Patents
Solid shaped articlesInfo
- Publication number
- CA1195250A CA1195250A CA000416516A CA416516A CA1195250A CA 1195250 A CA1195250 A CA 1195250A CA 000416516 A CA000416516 A CA 000416516A CA 416516 A CA416516 A CA 416516A CA 1195250 A CA1195250 A CA 1195250A
- Authority
- CA
- Canada
- Prior art keywords
- shaped article
- solvent
- chemical
- whenever prepared
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007787 solid Substances 0.000 title claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 51
- 239000002904 solvent Substances 0.000 claims abstract description 48
- 238000000034 method Methods 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 239000002552 dosage form Substances 0.000 claims abstract description 30
- 239000012876 carrier material Substances 0.000 claims abstract description 21
- 230000008014 freezing Effects 0.000 claims abstract description 5
- 238000007710 freezing Methods 0.000 claims abstract description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 26
- 108010010803 Gelatin Proteins 0.000 claims description 16
- 229920000159 gelatin Polymers 0.000 claims description 16
- 239000008273 gelatin Substances 0.000 claims description 16
- 235000019322 gelatine Nutrition 0.000 claims description 16
- 235000011852 gelatine desserts Nutrition 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 12
- 229920002307 Dextran Polymers 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 5
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 claims description 4
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 239000000902 placebo Substances 0.000 abstract description 17
- 229940068196 placebo Drugs 0.000 abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- BKYKPTRYDKTTJY-UHFFFAOYSA-N 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1CCCC1 BKYKPTRYDKTTJY-UHFFFAOYSA-N 0.000 description 5
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000004800 polyvinyl chloride Substances 0.000 description 5
- 229920000915 polyvinyl chloride Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000000859 sublimation Methods 0.000 description 5
- 230000008022 sublimation Effects 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229960003206 cyclopenthiazide Drugs 0.000 description 3
- 229960005156 digoxin Drugs 0.000 description 3
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 229960002415 trichloroethylene Drugs 0.000 description 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 2
- FJIKWRGCXUCUIG-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3h-1,4-benzodiazepin-2-one Chemical compound O=C([C@H](O)N=1)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1Cl FJIKWRGCXUCUIG-HNNXBMFYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- 229960002896 clonidine Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000007952 growth promoter Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000003617 indole-3-acetic acid Substances 0.000 description 2
- JTEDVYBZBROSJT-UHFFFAOYSA-N indole-3-butyric acid Chemical compound C1=CC=C2C(CCCC(=O)O)=CNC2=C1 JTEDVYBZBROSJT-UHFFFAOYSA-N 0.000 description 2
- 229960004400 levonorgestrel Drugs 0.000 description 2
- 229960004033 lormetazepam Drugs 0.000 description 2
- 229940127234 oral contraceptive Drugs 0.000 description 2
- 239000003539 oral contraceptive agent Substances 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 229960003188 temazepam Drugs 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Mechanical Engineering (AREA)
- Toxicology (AREA)
- Dentistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8137525 | 1981-12-11 | ||
| GB8137525 | 1981-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1195250A true CA1195250A (en) | 1985-10-15 |
Family
ID=10526565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000416516A Expired CA1195250A (en) | 1981-12-11 | 1982-11-26 | Solid shaped articles |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4754597A (OSRAM) |
| EP (1) | EP0084705B1 (OSRAM) |
| JP (1) | JPS58113124A (OSRAM) |
| KR (1) | KR880001207B1 (OSRAM) |
| AR (1) | AR229377A1 (OSRAM) |
| AT (1) | ATE24964T1 (OSRAM) |
| AU (1) | AU554431B2 (OSRAM) |
| BR (1) | BR8207187A (OSRAM) |
| CA (1) | CA1195250A (OSRAM) |
| DE (1) | DE3275121D1 (OSRAM) |
| DK (1) | DK157706C (OSRAM) |
| ES (1) | ES518082A0 (OSRAM) |
| GB (1) | GB2114440B (OSRAM) |
| GR (1) | GR77846B (OSRAM) |
| HU (1) | HU188234B (OSRAM) |
| IE (1) | IE53537B1 (OSRAM) |
| PH (1) | PH18298A (OSRAM) |
| PT (1) | PT75970B (OSRAM) |
| ZA (1) | ZA828739B (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0084705B1 (en) * | 1981-12-11 | 1987-01-14 | JOHN WYETH & BROTHER LIMITED | Process for preparing solid shaped articles |
| FR2602434A1 (fr) * | 1986-08-11 | 1988-02-12 | Analyses Conseils Production S | Procede de fabrication d'un element comportant une quantite determinee d'une substance donnee et element obtenu par ce procede |
| GB8624628D0 (en) * | 1986-10-14 | 1986-11-19 | Scras | Soluble/splitable tablets |
| US4907468A (en) * | 1986-11-14 | 1990-03-13 | Topre Corporation | Pedal effort-reduction apparatus |
| US4946684A (en) * | 1989-06-20 | 1990-08-07 | American Home Products Corporation | Fast dissolving dosage forms |
| US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
| US5215756A (en) * | 1989-12-22 | 1993-06-01 | Gole Dilip J | Preparation of pharmaceutical and other matrix systems by solid-state dissolution |
| GR910100193A (el) * | 1991-05-03 | 1993-03-31 | Mediventures Inc | Παρασκευη φαρμακευτικων και αλλων περιβληματων με διαλυση σε στερεα κατασταση. |
| DK0617613T3 (da) * | 1991-12-20 | 1996-06-17 | Pfizer | Porøse formgivne afgivelsesindretninger og fremgangsmåde til fremstilling deraf |
| US5343672A (en) * | 1992-12-01 | 1994-09-06 | Scherer Ltd R P | Method for manufacturing freeze dried dosages in a multilaminate blister pack |
| JP3722294B2 (ja) * | 1993-02-23 | 2005-11-30 | ワーナー−ランバート・コンパニー | 実質的にアルコールを含有しない医薬組成物の製造方法 |
| ES2162867T3 (es) * | 1993-07-09 | 2002-01-16 | Scherer Corp R P | Metodo de fabricacion de formas de dosificacion de farmacos liofilizados. |
| GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| GB9504201D0 (en) * | 1995-03-02 | 1995-04-19 | Scherer Ltd R P | Process for the preparation of a solid pharmaceutical dosage form |
| GB9717770D0 (en) * | 1997-08-21 | 1997-10-29 | Scherer Ltd R P | Pharmaceutical composition |
| FR2768341B1 (fr) * | 1997-09-18 | 2000-04-14 | Lab Francais Du Fractionnement | Composition pharmaceutique placebo lyophilisable destinee a imiter un medicament, notamment a base de proteines ou de polypeptides |
| TW527195B (en) | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
| US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| AU765526B2 (en) * | 1999-08-17 | 2003-09-18 | Novartis Consumer Health S.A. | Rapidly dissolving dosage form and process for making same |
| US20050260273A1 (en) * | 2001-06-07 | 2005-11-24 | Chinea Vanessa I | Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology |
| RU2004107501A (ru) * | 2001-08-14 | 2005-02-20 | Байотай Терапис Корпорейшн (Fi) | Способ лечения алкоголизма или злоупотребления алкоголем |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| US20040029843A1 (en) * | 2002-06-20 | 2004-02-12 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
| US20040234579A1 (en) * | 2003-05-22 | 2004-11-25 | Mark D. Finke, Inc. | Dietary supplements and methods of preparing and administering dietary supplements |
| US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
| DE20321887U1 (de) | 2003-11-10 | 2012-01-20 | Allergan, Inc. | Arzneimittel umfassend niedrige Dosierungen von Desmopressin |
| EP2322196A2 (en) | 2003-11-10 | 2011-05-18 | Reprise Biopharmaceutics, LLC | Pharmaceutical compositions including low dosages of desmopressin |
| PT1530967E (pt) | 2003-11-13 | 2006-09-29 | Ferring Bv | Embalagem blister e uma forma de dosagem solida que compreende desmopressina. |
| KR101379297B1 (ko) * | 2004-10-28 | 2014-04-10 | 팬택 아게 | 고 다공성, 속해성 고형 투여 형태 및 분말 제조 및동결건조 단계를 포함하는 그의 제조 방법 |
| US20090130212A1 (en) * | 2006-05-15 | 2009-05-21 | Physical Pharmaceutica, Llc | Composition and improved method for preparation of small particles |
| WO2007147133A1 (en) * | 2006-06-15 | 2007-12-21 | Serenex, Inc. | Stabilized tetracycline compositions |
| DE102006054638B4 (de) * | 2006-11-16 | 2014-12-04 | Laburnum Gmbh | Pharmazeutische Einzeldosisform |
| HUE041370T2 (hu) | 2008-05-21 | 2019-05-28 | Ferring Bv | Orodiszperzibilis dezmopresszin az alvás noktúria által meg nem zavart kezdeti szakaszának megnövelésére |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| JP6173495B2 (ja) | 2013-05-29 | 2017-08-02 | ゲア・プロセス・エンジニアリング・アクティーゼルスカブ | トロリに収容されたトレイ内の製品の直列滅菌凍結乾燥を実現する方法、方法を実施するためのシステム、および方法の使用 |
| CN106999436B (zh) * | 2014-10-01 | 2021-07-02 | 奥克希托恩生物科学公司 | 含有分娩控制物质的口服崩解固体药物剂量单元 |
| US9901545B1 (en) | 2017-04-13 | 2018-02-27 | Richard C. Fuisz | Method and composition for making an oral soluble film, containing at least one active agent |
| US10238600B2 (en) | 2017-04-13 | 2019-03-26 | Richard C. Fuisz | Package, system and methods for custody and control of drugs, and method and composition for making an oral soluble film, containing at least one active agent |
| US11173114B1 (en) | 2020-07-10 | 2021-11-16 | Nova Thin Film Pharmaceuticals Llc | Method and system for manufacturing and oral soluble films and oral soluble films made by thereby |
| WO2022178279A1 (en) | 2021-02-19 | 2022-08-25 | Nova Thin Film Pharmaceuticals Llc | Method and system for manufacturing oral soluble films, compositions of oral soluble films, oral soluble films made by thereby, and methods of use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB801856A (en) * | 1955-02-25 | 1958-09-24 | Bayer Ag | The production of lyophilised preparations |
| US3269905A (en) * | 1955-03-02 | 1966-08-30 | Charles W Damaskus | Dry stratiform products and methods of producing same |
| FR1382158A (fr) * | 1963-09-12 | 1964-12-18 | Ciba Geigy | Nouveaux médicaments et procédé pour leur préparation |
| GB1061557A (en) * | 1964-04-01 | 1967-03-15 | Ashe Chemical Ltd | New impregnated or coated films |
| CH463935A (fr) * | 1966-07-08 | 1968-10-15 | Nestle Sa | Procédé de fabrication d'un produit complexe à structure poreuse et produit obtenu par ce procédé |
| US3669663A (en) * | 1970-12-17 | 1972-06-13 | Ibm | Preparation of silver halide grains and photographic emulsions |
| GB1379314A (en) * | 1972-03-17 | 1975-01-02 | Unilever Ltd | Method of drying foodstuffs |
| GB1447988A (en) * | 1973-04-03 | 1976-09-02 | Orsymonde | Pharmaceutical compositions |
| US4021280A (en) * | 1975-09-02 | 1977-05-03 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method of making foam-encapsulated laser targets |
| GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| CA1097233A (en) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
| DE2922522A1 (de) * | 1979-06-01 | 1980-12-04 | Dudzik Joachim | Tablette |
| EP0084705B1 (en) * | 1981-12-11 | 1987-01-14 | JOHN WYETH & BROTHER LIMITED | Process for preparing solid shaped articles |
-
1982
- 1982-11-19 EP EP82306168A patent/EP0084705B1/en not_active Expired
- 1982-11-19 AT AT82306168T patent/ATE24964T1/de not_active IP Right Cessation
- 1982-11-19 DE DE8282306168T patent/DE3275121D1/de not_active Expired
- 1982-11-22 GB GB08233225A patent/GB2114440B/en not_active Expired
- 1982-11-23 IE IE2787/82A patent/IE53537B1/en not_active IP Right Cessation
- 1982-11-25 AU AU90869/82A patent/AU554431B2/en not_active Expired
- 1982-11-26 ZA ZA828739A patent/ZA828739B/xx unknown
- 1982-11-26 CA CA000416516A patent/CA1195250A/en not_active Expired
- 1982-12-01 AR AR291469A patent/AR229377A1/es active
- 1982-12-02 GR GR69961A patent/GR77846B/el unknown
- 1982-12-08 PH PH28247A patent/PH18298A/en unknown
- 1982-12-10 KR KR8205544A patent/KR880001207B1/ko not_active Expired
- 1982-12-10 DK DK551082A patent/DK157706C/da not_active IP Right Cessation
- 1982-12-10 ES ES518082A patent/ES518082A0/es active Granted
- 1982-12-10 PT PT75970A patent/PT75970B/pt unknown
- 1982-12-10 BR BR8207187A patent/BR8207187A/pt not_active IP Right Cessation
- 1982-12-10 HU HU823998A patent/HU188234B/hu unknown
- 1982-12-11 JP JP57217672A patent/JPS58113124A/ja active Granted
-
1987
- 1987-03-30 US US07/031,225 patent/US4754597A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE24964T1 (de) | 1987-01-15 |
| DK157706C (da) | 1990-07-16 |
| DE3275121D1 (en) | 1987-02-19 |
| ES8400870A1 (es) | 1983-12-16 |
| KR840002649A (ko) | 1984-07-16 |
| GB2114440B (en) | 1985-07-03 |
| DK551082A (da) | 1983-06-12 |
| ES518082A0 (es) | 1983-12-16 |
| PH18298A (en) | 1985-05-29 |
| AU9086982A (en) | 1983-06-16 |
| JPH0457643B2 (OSRAM) | 1992-09-14 |
| DK157706B (da) | 1990-02-05 |
| AU554431B2 (en) | 1986-08-21 |
| US4754597A (en) | 1988-07-05 |
| GB2114440A (en) | 1983-08-24 |
| ZA828739B (en) | 1984-07-25 |
| EP0084705A3 (en) | 1984-07-18 |
| IE53537B1 (en) | 1988-12-07 |
| IE822787L (en) | 1983-06-11 |
| HU188234B (en) | 1986-03-28 |
| KR880001207B1 (ko) | 1988-07-11 |
| EP0084705B1 (en) | 1987-01-14 |
| AR229377A1 (es) | 1983-07-29 |
| BR8207187A (pt) | 1983-10-11 |
| JPS58113124A (ja) | 1983-07-05 |
| PT75970B (en) | 1985-02-27 |
| PT75970A (en) | 1983-01-01 |
| GR77846B (OSRAM) | 1984-09-25 |
| EP0084705A2 (en) | 1983-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1195250A (en) | Solid shaped articles | |
| US4371516A (en) | Articles for carrying chemicals | |
| US5631023A (en) | Method for making freeze dried drug dosage forms | |
| Panigrahi et al. | A review on fast dissolving tablets | |
| EP0879049B1 (en) | Process to prepare soluble delivery systems using volatile salts | |
| GB2111423A (en) | Moulding quick-dissolving dosage units | |
| CN101987082B (zh) | 固体制剂及其制备方法 | |
| DK167171B1 (da) | Fremgangsmaade til fremstilling af et stabilt nicorandilholdigt farmaceutisk praeparat | |
| AU653372B2 (en) | Controlled release compositions | |
| UA44904C2 (uk) | Лікарський засіб з пролонгованою дією на основі капсульованого гідрохлориду венлафаксину та способи лікування | |
| RU2101009C1 (ru) | Твердая лекарственная форма для орального применения с замедленным высвобождением активного вещества и способ ее изготовления (варианты) | |
| IE45770B1 (en) | Pharmaceutical dosage forms | |
| Beri et al. | Development of fast disintegration tablets as oral drug delivery system-A review | |
| WO2008029417A2 (en) | Pharmaceutical formulation for use in hiv therapy | |
| Buwade et al. | Advantages of immediate release tablets over the other tablet forms | |
| Joshi et al. | Review on mouth dissolving tablet | |
| Arunachalam et al. | Fast dissolving drug delivery system: A review | |
| JP4944327B2 (ja) | 急速に崩壊するキトサンを原料とするペレット | |
| JPH09316006A (ja) | 口腔内溶解性固形製剤 | |
| RU2079301C1 (ru) | Способ регулируемого выделения активного вещества из состава | |
| RU2074729C1 (ru) | Лекарственное средство для лечения язвенной болезни желудка и 12-перстной кишки "ахигран" | |
| Dhanakishore et al. | A review of immediate drug release dosage forms | |
| Alexander et al. | Technologies influencing rapidly disintegrating drug delivery systems: A review | |
| Patel | An overview of formulation and evaluation aspects of fast dissolving oral films | |
| JPS615027A (ja) | 徐放性固形製剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEC | Expiry (correction) | ||
| MKEX | Expiry |