CA1152080A - 3-(2-hydroxy-3-aminopropyl)-pyridoxine - Google Patents

3-(2-hydroxy-3-aminopropyl)-pyridoxine

Info

Publication number
CA1152080A
CA1152080A CA000377739A CA377739A CA1152080A CA 1152080 A CA1152080 A CA 1152080A CA 000377739 A CA000377739 A CA 000377739A CA 377739 A CA377739 A CA 377739A CA 1152080 A CA1152080 A CA 1152080A
Authority
CA
Canada
Prior art keywords
methyl
acid
pharmaceutically acceptable
ethyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000377739A
Other languages
English (en)
French (fr)
Inventor
Marcel Descamps
Marcel Urbain, (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz Sanofi NV
Original Assignee
Labaz Sanofi NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz Sanofi NV filed Critical Labaz Sanofi NV
Application granted granted Critical
Publication of CA1152080A publication Critical patent/CA1152080A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000377739A 1980-05-19 1981-05-15 3-(2-hydroxy-3-aminopropyl)-pyridoxine Expired CA1152080A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8016516 1980-05-19
GB8016516 1980-05-19

Publications (1)

Publication Number Publication Date
CA1152080A true CA1152080A (en) 1983-08-16

Family

ID=10513518

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000377739A Expired CA1152080A (en) 1980-05-19 1981-05-15 3-(2-hydroxy-3-aminopropyl)-pyridoxine

Country Status (32)

Country Link
US (1) US4374841A (online.php)
EP (1) EP0040591B1 (online.php)
JP (1) JPS5711966A (online.php)
AR (1) AR226356A1 (online.php)
AT (1) ATE3859T1 (online.php)
AU (1) AU542463B2 (online.php)
BG (1) BG35327A3 (online.php)
CA (1) CA1152080A (online.php)
CS (1) CS223842B2 (online.php)
DD (1) DD159071A5 (online.php)
DE (1) DE3160480D1 (online.php)
DK (1) DK217481A (online.php)
EG (1) EG15890A (online.php)
ES (1) ES8203845A1 (online.php)
FI (1) FI811525A7 (online.php)
GR (1) GR82343B (online.php)
HU (1) HU183441B (online.php)
IE (1) IE51179B1 (online.php)
IL (1) IL62602A (online.php)
IN (1) IN151915B (online.php)
IS (1) IS1183B6 (online.php)
MA (1) MA19147A1 (online.php)
NO (1) NO811680L (online.php)
NZ (1) NZ196766A (online.php)
OA (1) OA06811A (online.php)
PL (1) PL129213B1 (online.php)
PT (1) PT72992B (online.php)
RO (1) RO81943A (online.php)
SU (1) SU1077566A3 (online.php)
YU (1) YU126281A (online.php)
ZA (1) ZA812448B (online.php)
ZW (1) ZW9681A1 (online.php)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663354A (en) * 1984-04-26 1987-05-05 Klinge Pharma Gmbh Use of etilefrin and etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
EP1169322B8 (en) 1999-03-08 2006-09-13 Medicure Inc. Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin b6
AU5840200A (en) 1999-07-13 2001-01-30 Medicure Inc. Treatment of diabetes and related pathologies
EP1872797A3 (en) 1999-08-24 2008-04-02 Medicure International Inc. Treatment of cardiovascular and related pathologies
EP1268498B1 (en) 2000-02-29 2005-04-13 Medicure International Inc. Cardioprotective phosphonates
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
US6586414B2 (en) 2000-03-28 2003-07-01 Medicure International Inc. Treatment of cerebrovascular disease
DE60128912T9 (de) 2000-07-07 2008-06-26 Medicure International Inc. Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
JP4048166B2 (ja) * 2002-11-18 2008-02-13 三井製糖株式会社 血糖値上昇抑制剤及び体脂肪蓄積抑制剤並びに食用材料
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
EP1608379A1 (en) * 2003-03-27 2005-12-28 Medicure Inc. Compositions for treating angina
EP1773370A1 (en) * 2004-07-07 2007-04-18 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
WO2006050598A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
JP2009517411A (ja) * 2005-11-28 2009-04-30 メディキュア インターナショナル インコーポレーテッド 心血管及び関連病状の処置のための調剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
GB1485919A (en) * 1975-08-12 1977-09-14 Grindstedvaerket As Pyridine derivatives
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines

Also Published As

Publication number Publication date
AR226356A1 (es) 1982-06-30
ZA812448B (en) 1982-04-28
EG15890A (en) 1987-03-30
IS1183B6 (is) 1985-05-13
IS2631A7 (is) 1981-11-11
IE811085L (en) 1981-11-19
MA19147A1 (fr) 1981-12-31
SU1077566A3 (ru) 1984-02-29
ES502276A0 (es) 1982-04-01
PL129213B1 (en) 1984-04-30
EP0040591A1 (fr) 1981-11-25
EP0040591B1 (fr) 1983-06-22
NO811680L (no) 1981-11-20
IN151915B (online.php) 1983-09-03
RO81943B (ro) 1983-05-30
AU542463B2 (en) 1985-02-21
PT72992A (en) 1981-06-01
OA06811A (fr) 1982-12-31
YU126281A (en) 1984-02-29
ES8203845A1 (es) 1982-04-01
BG35327A3 (bg) 1984-03-15
DE3160480D1 (en) 1983-07-28
US4374841A (en) 1983-02-22
DK217481A (da) 1981-11-20
HU183441B (en) 1984-05-28
AU7053581A (en) 1981-11-26
ZW9681A1 (en) 1982-01-20
DD159071A5 (de) 1983-02-16
IL62602A (en) 1984-06-29
FI811525L (fi) 1981-11-20
NZ196766A (en) 1984-02-03
PT72992B (en) 1982-07-01
ATE3859T1 (de) 1983-07-15
PL231193A1 (online.php) 1982-07-05
JPS5711966A (en) 1982-01-21
CS223842B2 (en) 1983-11-25
GR82343B (online.php) 1984-12-13
IE51179B1 (en) 1986-10-29
IL62602A0 (en) 1981-06-29
FI811525A7 (fi) 1981-11-20
RO81943A (ro) 1983-06-01

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Legal Events

Date Code Title Description
MKEX Expiry