CA1128038A - Bromination process of ergot alkaloids - Google Patents

Bromination process of ergot alkaloids

Info

Publication number
CA1128038A
CA1128038A CA336,448A CA336448A CA1128038A CA 1128038 A CA1128038 A CA 1128038A CA 336448 A CA336448 A CA 336448A CA 1128038 A CA1128038 A CA 1128038A
Authority
CA
Canada
Prior art keywords
alkyl
bromo
methyl
chloro
amido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA336,448A
Other languages
English (en)
French (fr)
Inventor
Milan Jurgec
Branko Stanovnik
Rudolf Rucman
Miha Tisler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1128038A publication Critical patent/CA1128038A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CA336,448A 1978-09-26 1979-09-26 Bromination process of ergot alkaloids Expired CA1128038A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU2268/78A YU39849B (en) 1978-09-26 1978-09-26 Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
YUP2268/78 1978-09-26

Publications (1)

Publication Number Publication Date
CA1128038A true CA1128038A (en) 1982-07-20

Family

ID=25557457

Family Applications (1)

Application Number Title Priority Date Filing Date
CA336,448A Expired CA1128038A (en) 1978-09-26 1979-09-26 Bromination process of ergot alkaloids

Country Status (45)

Country Link
JP (1) JPS5545699A (xx)
AR (1) AR223496A1 (xx)
AT (1) AT376439B (xx)
AU (1) AU529462B2 (xx)
BE (1) BE878953A (xx)
BG (1) BG32716A3 (xx)
BR (1) BR7906175A (xx)
CA (1) CA1128038A (xx)
CH (1) CH649769A5 (xx)
CS (1) CS215027B2 (xx)
CY (1) CY1240A (xx)
DD (1) DD146048A5 (xx)
DE (1) DE2938313A1 (xx)
DK (1) DK149956C (xx)
EG (1) EG14277A (xx)
ES (1) ES484445A1 (xx)
FI (1) FI66185C (xx)
FR (1) FR2437411A1 (xx)
GB (1) GB2031890B (xx)
GR (1) GR73015B (xx)
HK (1) HK49184A (xx)
HU (1) HU182576B (xx)
IE (1) IE49076B1 (xx)
IL (1) IL58318A (xx)
IN (1) IN154914B (xx)
IS (1) IS2512A7 (xx)
IT (1) IT1206988B (xx)
KE (1) KE3392A (xx)
LU (1) LU81714A1 (xx)
MA (1) MA18595A1 (xx)
MX (1) MX5864E (xx)
MY (1) MY8500131A (xx)
NL (1) NL7907122A (xx)
NO (1) NO153852C (xx)
NZ (1) NZ191643A (xx)
PH (1) PH14986A (xx)
PL (1) PL120388B1 (xx)
PT (1) PT70216A (xx)
RO (1) RO78936A (xx)
SE (1) SE433497B (xx)
SG (1) SG20484G (xx)
SU (1) SU1178324A3 (xx)
UA (1) UA7078A1 (xx)
YU (1) YU39849B (xx)
ZA (1) ZA795110B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
CN104016982A (zh) * 2014-06-26 2014-09-03 华东理工大学 一种利用大孔树脂制备烟曲霉文丙的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
YU39786B (en) * 1976-12-23 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-alfa-ergocriptine
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine

Also Published As

Publication number Publication date
IS1161B6 (is) 1984-05-10
JPS5545699A (en) 1980-03-31
NL7907122A (nl) 1980-03-28
HU182576B (en) 1984-02-28
CS215027B2 (en) 1982-06-25
ATA624379A (de) 1984-04-15
PL218497A1 (xx) 1980-07-14
CY1240A (en) 1984-06-29
NO153852C (no) 1986-06-04
IE49076B1 (en) 1985-07-24
DK149956C (da) 1987-05-18
HK49184A (en) 1984-06-22
YU39849B (en) 1985-04-30
ZA795110B (en) 1981-05-27
RO78936A (ro) 1982-07-06
NO793058L (no) 1980-03-27
DK149956B (da) 1986-11-03
FR2437411B1 (xx) 1983-03-18
BG32716A3 (en) 1982-09-15
FI66185B (fi) 1984-05-31
GR73015B (xx) 1984-01-25
MY8500131A (en) 1985-12-31
PL120388B1 (en) 1982-02-27
MX5864E (es) 1984-08-13
IN154914B (xx) 1984-12-22
SG20484G (en) 1985-03-08
NO153852B (no) 1986-02-24
AT376439B (de) 1984-11-26
AU529462B2 (en) 1983-06-09
PT70216A (en) 1979-10-01
IL58318A (en) 1982-07-30
DD146048A5 (de) 1981-01-21
IT7950300A0 (it) 1979-09-19
JPS6239158B2 (xx) 1987-08-21
GB2031890B (en) 1983-02-02
CH649769A5 (de) 1985-06-14
DE2938313A1 (de) 1980-04-10
PH14986A (en) 1982-03-05
DK401979A (da) 1980-03-27
AU5117279A (en) 1980-04-03
GB2031890A (en) 1980-04-30
IL58318A0 (en) 1979-12-30
BE878953A (fr) 1980-03-24
SU1178324A3 (ru) 1985-09-07
YU226878A (en) 1983-01-21
IE791832L (en) 1980-03-26
ES484445A1 (es) 1980-09-01
IS2512A7 (is) 1988-03-27
NZ191643A (en) 1982-05-25
LU81714A1 (fr) 1980-04-21
SE7907942L (sv) 1980-03-27
IT1206988B (it) 1989-05-17
KE3392A (en) 1984-06-08
DE2938313C2 (xx) 1988-07-07
EG14277A (en) 1990-06-30
SE433497B (sv) 1984-05-28
MA18595A1 (fr) 1980-04-01
FI792957A (fi) 1980-03-27
FI66185C (fi) 1984-09-10
FR2437411A1 (fr) 1980-04-25
AR223496A1 (es) 1981-08-31
BR7906175A (pt) 1980-05-27
UA7078A1 (uk) 1995-06-30

Similar Documents

Publication Publication Date Title
GB1605176A (en) Oxime derivatives of 7-amino-thiazolyl-acetic acid and processes for preparing them
US4196292A (en) 6-Substituted amiloride derivatives
CA1128038A (en) Bromination process of ergot alkaloids
JPS5929050B2 (ja) シクロヘキサンジオン−(1,3)の製法
JPS58189132A (ja) ブテン誘導体の製造方法
US4609731A (en) Process for brominating ergot alkaloids
Reckhow et al. Hexahydroindolo [2, 3-a] quinolizine1
CA2233807C (en) Chlorination of substituted alkenes using tricholorisocyanuric acid
Barluenga et al. Regiospecific synthesis of isoxazoles by reaction of 1-azabutadiene derivatives with hydroxylamine hydrochloride
Bickel On the Structure of Leucaenine (Leucaenol) from Leucaena glauca Bentham. II.
US4021478A (en) Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
JPH051071A (ja) 抗アテローム性動脈硬化症フロクロモン
JP3544727B2 (ja) 2,4,5−トリブロモピロール−3−カルボニトリルの調製方法
Comins et al. Bromination of 1-alkyl-3-methyl-2-pyridones with N-bromosuccinimide
KR830001840B1 (ko) 진보된 브롬화 방법
CA1146977A (en) Process for the preparation of dihalovinyl compounds
IE44449B1 (en) 11-methylene-6-piperazinyl-morphanthridine derivatives
CA1039750A (en) PROCESS FOR THE PREPARATION OF .alpha.-DIOL-.gamma.-DIOXO COMPOUNDS
US2889325A (en) Derivatives of 1, 3 (2h)-dioxo-1-pyrazolo [a]-benzo [c] cinnoline
JP2512958B2 (ja) 1−ビフェニリルエタノ―ル誘導体およびその製法
JPS63421B2 (xx)
CA1151659A (en) Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
CA1049035A (en) Process for the preparation of triesters and products thus obtained
JPS5910358B2 (ja) 新規エルゴリン誘導体
Suzuki et al. Facile cleavage of aryl haloacetates and 2-chloroethyl carboxylic esters with sodium telluride. A one-pot conversion of aryl esters into aryl ethers under aprotic conditions.

Legal Events

Date Code Title Description
MKEX Expiry