ES484445A1 - Un procedimiento para la bromacionde derivados de alealoi- des del cornezuelo del centeno. - Google Patents
Un procedimiento para la bromacionde derivados de alealoi- des del cornezuelo del centeno.Info
- Publication number
- ES484445A1 ES484445A1 ES484445A ES484445A ES484445A1 ES 484445 A1 ES484445 A1 ES 484445A1 ES 484445 A ES484445 A ES 484445A ES 484445 A ES484445 A ES 484445A ES 484445 A1 ES484445 A1 ES 484445A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- brominated
- amido
- preparation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la bromación de derivados de alcaloides de cornezuelo del centro de formula I. **( formula-01)** donde R1 es carboxilo, alcoxi (C1-5) carbonilo, amido, alquil (c1-5) amido, di( alquil(C1-5)) amido o un radical amido de formula II:**( formula-02)** donde Ra es alquilo (C1-4), y Rb es alquilo (C1-4) o bencilo, R2 es hidrógeno o alquilo ( C1-4), y ó R3 es hidrógeno y R4 es hidrógeno o alcoxi ( C1-4), ó R3 y R4, juntas, son un enlace simple, caracterizado porque se hace reaccionar un compuesto de fórmula III: **( formula-03)** donde R1 a R4 tienen los significados previamente indicados, con un complejo de bromo de 3-bromo-6-cloro-2-metil-imidazo [1,2-b] piridacina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU2268/78A YU39849B (en) | 1978-09-26 | 1978-09-26 | Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484445A1 true ES484445A1 (es) | 1980-09-01 |
Family
ID=25557457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484445A Expired ES484445A1 (es) | 1978-09-26 | 1979-09-25 | Un procedimiento para la bromacionde derivados de alealoi- des del cornezuelo del centeno. |
Country Status (45)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU196394B (en) * | 1986-06-27 | 1988-11-28 | Richter Gedeon Vegyeszet | Process for preparing 2-halogenated ergoline derivatives |
| CN104016982A (zh) * | 2014-06-26 | 2014-09-03 | 华东理工大学 | 一种利用大孔树脂制备烟曲霉文丙的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH507249A (de) * | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| YU39786B (en) * | 1976-12-23 | 1985-04-30 | Lek Tovarna Farmacevtskih | Process for preparing 2-bromo-alfa-ergocriptine |
| YU216177A (en) * | 1977-09-09 | 1984-02-29 | Rudolf Rucman | Process for preparing 2-bromo ergosine |
-
1978
- 1978-09-26 YU YU2268/78A patent/YU39849B/xx unknown
-
1979
- 1979-09-19 IT IT7950300A patent/IT1206988B/it active
- 1979-09-20 CH CH8492/79A patent/CH649769A5/de not_active IP Right Cessation
- 1979-09-21 DE DE19792938313 patent/DE2938313A1/de active Granted
- 1979-09-24 GB GB7932989A patent/GB2031890B/en not_active Expired
- 1979-09-24 AR AR278180A patent/AR223496A1/es active
- 1979-09-24 NZ NZ191643A patent/NZ191643A/xx unknown
- 1979-09-24 GR GR60103A patent/GR73015B/el unknown
- 1979-09-24 AT AT0624379A patent/AT376439B/de not_active IP Right Cessation
- 1979-09-24 IS IS2512A patent/IS2512A7/is unknown
- 1979-09-24 FI FI792957A patent/FI66185C/fi not_active IP Right Cessation
- 1979-09-24 MX MX798393U patent/MX5864E/es unknown
- 1979-09-24 CY CY1240A patent/CY1240A/xx unknown
- 1979-09-24 DD DD79215747A patent/DD146048A5/de not_active IP Right Cessation
- 1979-09-24 PT PT70216A patent/PT70216A/pt unknown
- 1979-09-24 BE BE1/9540A patent/BE878953A/fr not_active IP Right Cessation
- 1979-09-24 LU LU81714A patent/LU81714A1/fr unknown
- 1979-09-24 HU HU79SA3200A patent/HU182576B/hu unknown
- 1979-09-24 NO NO793058A patent/NO153852C/no unknown
- 1979-09-25 NL NL7907122A patent/NL7907122A/nl not_active Application Discontinuation
- 1979-09-25 PL PL1979218497A patent/PL120388B1/pl unknown
- 1979-09-25 RO RO7998760A patent/RO78936A/ro unknown
- 1979-09-25 SE SE7907942A patent/SE433497B/sv not_active IP Right Cessation
- 1979-09-25 MA MA18795A patent/MA18595A1/fr unknown
- 1979-09-25 CS CS796471A patent/CS215027B2/cs unknown
- 1979-09-25 IL IL58318A patent/IL58318A/xx unknown
- 1979-09-25 ES ES484445A patent/ES484445A1/es not_active Expired
- 1979-09-25 PH PH23062A patent/PH14986A/en unknown
- 1979-09-25 DK DK401979A patent/DK149956C/da not_active IP Right Cessation
- 1979-09-25 AU AU51172/79A patent/AU529462B2/en not_active Ceased
- 1979-09-25 EG EG566/79A patent/EG14277A/xx active
- 1979-09-25 JP JP12373279A patent/JPS5545699A/ja active Granted
- 1979-09-25 BG BG7944956A patent/BG32716A3/xx unknown
- 1979-09-25 UA UA2818045A patent/UA7078A1/uk unknown
- 1979-09-25 FR FR7923816A patent/FR2437411A1/fr active Granted
- 1979-09-25 SU SU792818045A patent/SU1178324A3/ru active
- 1979-09-26 IE IE1832/79A patent/IE49076B1/en not_active IP Right Cessation
- 1979-09-26 CA CA336,448A patent/CA1128038A/en not_active Expired
- 1979-09-26 ZA ZA00795110A patent/ZA795110B/xx unknown
- 1979-09-26 BR BR7906175A patent/BR7906175A/pt unknown
-
1980
- 1980-09-23 IN IN1077/CAL/80A patent/IN154914B/en unknown
-
1984
- 1984-03-05 SG SG204/84A patent/SG20484G/en unknown
- 1984-04-12 KE KE3392A patent/KE3392A/xx unknown
- 1984-06-14 HK HK491/84A patent/HK49184A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY131/85A patent/MY8500131A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20001009 |