CA1085298A - Topical pharmaceutical composition - Google Patents
Topical pharmaceutical compositionInfo
- Publication number
- CA1085298A CA1085298A CA278,142A CA278142A CA1085298A CA 1085298 A CA1085298 A CA 1085298A CA 278142 A CA278142 A CA 278142A CA 1085298 A CA1085298 A CA 1085298A
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- active ingredient
- propyl
- tetrahydro
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012049 topical pharmaceutical composition Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract description 28
- 150000001875 compounds Chemical class 0.000 claims abstract description 23
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 239000001257 hydrogen Substances 0.000 claims abstract description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 5
- 239000001301 oxygen Substances 0.000 claims abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- 150000002431 hydrogen Chemical group 0.000 claims abstract description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 125000001424 substituent group Chemical group 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 33
- 239000002674 ointment Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000012188 paraffin wax Substances 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 6
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000010410 dusting Methods 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
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- 150000003536 tetrazoles Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- DLKZWVIRKURGIR-UHFFFAOYSA-N 4-oxo-10-propyl-6,7,8,9-tetrahydrobenzo[g]chromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1CCCCC1=C2 DLKZWVIRKURGIR-UHFFFAOYSA-N 0.000 claims 1
- PZSXHEQDVQGUDR-UHFFFAOYSA-N 5-amino-4-oxo-10-propyl-6,7,8,9-tetrahydrobenzo[g]chromene-2-carboxylic acid Chemical group O1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1CCCCC1=C2N PZSXHEQDVQGUDR-UHFFFAOYSA-N 0.000 claims 1
- VFFTVZUIDYJUQS-UHFFFAOYSA-N 5-hydroxy-4-oxo-10-propyl-6,7,8,9-tetrahydrobenzo[g]chromene-2-carboxylic acid Chemical group O1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1CCCCC1=C2O VFFTVZUIDYJUQS-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
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- 230000003111 delayed effect Effects 0.000 abstract description 5
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- 238000006243 chemical reaction Methods 0.000 description 9
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- 150000001298 alcohols Chemical class 0.000 description 4
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- 206010003645 Atopy Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
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- 210000001015 abdomen Anatomy 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
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- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
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- 208000035475 disorder Diseases 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
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- 238000002347 injection Methods 0.000 description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
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- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- SJHPCNCNNSSLPL-CSKARUKUSA-N (4e)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical compound O1C(=O)C(=C/OCC)\N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-CSKARUKUSA-N 0.000 description 1
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- NJXWZWXCHBNOOG-UHFFFAOYSA-N 3,3-diphenylpropyl(1-phenylethyl)azanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1C(C)[NH2+]CCC(C=1C=CC=CC=1)C1=CC=CC=C1 NJXWZWXCHBNOOG-UHFFFAOYSA-N 0.000 description 1
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- 229960005486 vaccine Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB20986/76 | 1976-05-21 | ||
| GB20986/76A GB1560489A (en) | 1976-05-21 | 1976-05-21 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1085298A true CA1085298A (en) | 1980-09-09 |
Family
ID=10155228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA278,142A Expired CA1085298A (en) | 1976-05-21 | 1977-05-09 | Topical pharmaceutical composition |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4160844A (OSRAM) |
| JP (1) | JPS5315428A (OSRAM) |
| AU (1) | AU508191B2 (OSRAM) |
| BE (1) | BE854691A (OSRAM) |
| CA (1) | CA1085298A (OSRAM) |
| DE (1) | DE2722916A1 (OSRAM) |
| DK (1) | DK223377A (OSRAM) |
| FI (1) | FI771582A7 (OSRAM) |
| FR (1) | FR2361387A1 (OSRAM) |
| GB (1) | GB1560489A (OSRAM) |
| IE (1) | IE45200B1 (OSRAM) |
| IL (1) | IL52103A (OSRAM) |
| LU (1) | LU77365A1 (OSRAM) |
| NL (1) | NL7705561A (OSRAM) |
| NO (1) | NO771766L (OSRAM) |
| NZ (1) | NZ184140A (OSRAM) |
| SE (1) | SE7705851L (OSRAM) |
| ZA (1) | ZA772990B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1560489A (en) * | 1976-05-21 | 1980-02-06 | Fisons Ltd | Pharmaceutical compositions |
| EP0008167A1 (en) * | 1978-08-15 | 1980-02-20 | FISONS plc | Improved process for the production of 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho(2,3-b)pyran-2-carboxylic acid |
| HUT51488A (en) * | 1988-04-11 | 1990-05-28 | May & Baker Ltd | Process for production of medical compositions containing derivatives of tetrasole |
| ES2204952T3 (es) * | 1994-05-27 | 2004-05-01 | Glaxosmithkline S.P.A. | Derivados de la quinoleina utiles como antagonistas del receptor nk3 de la taquiquinina. |
| KR100491303B1 (ko) | 1996-12-09 | 2005-05-24 | 가오가부시끼가이샤 | 세정제 함침 물품 |
| ES2288942T3 (es) * | 2001-03-30 | 2008-02-01 | Color Access, Inc. | Colorantes encapsulados en composiciones cosmeticas. |
| US7115287B2 (en) * | 2005-03-03 | 2006-10-03 | F.L.M., L.L.C. | Topical medicament and method of use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE817137C (de) * | 1948-10-02 | 1951-10-15 | Neuerburg Obsterei K G | Walze zum Kristallisieren von Fluessigkeiten |
| US3864493A (en) * | 1967-08-17 | 1975-02-04 | Fisons Ltd Felixstowe | Compositions and methods for the prevention of asthmatic symptoms |
| US3873714A (en) * | 1971-07-14 | 1975-03-25 | Syntex Inc | Xanthone carboxylic acids and derivatives |
| US4133889A (en) * | 1971-07-29 | 1979-01-09 | Fisons, Ltd. | 2(5-Tetrazolyl)chromones |
| GB1389227A (en) * | 1971-09-16 | 1975-04-03 | Fisons Ltd | Chromone-2-carboxylic acid derivatives methods for their preparation and compositions containing them |
| JPS5118955B2 (OSRAM) * | 1972-04-12 | 1976-06-14 | ||
| GB1517153A (en) | 1974-11-30 | 1978-07-12 | Fisons Ltd | Naphthopyran-and benzodipyran-2-carboxylic acids and derivatives thereof |
| GB1560489A (en) * | 1976-05-21 | 1980-02-06 | Fisons Ltd | Pharmaceutical compositions |
-
1976
- 1976-05-21 GB GB20986/76A patent/GB1560489A/en not_active Expired
-
1977
- 1977-05-05 US US05/794,030 patent/US4160844A/en not_active Expired - Lifetime
- 1977-05-09 CA CA278,142A patent/CA1085298A/en not_active Expired
- 1977-05-16 BE BE177620A patent/BE854691A/xx unknown
- 1977-05-16 FR FR7714859A patent/FR2361387A1/fr active Granted
- 1977-05-16 IL IL52103A patent/IL52103A/xx unknown
- 1977-05-17 SE SE7705851A patent/SE7705851L/xx unknown
- 1977-05-17 AU AU25196/77A patent/AU508191B2/en not_active Expired
- 1977-05-18 FI FI771582A patent/FI771582A7/fi not_active Application Discontinuation
- 1977-05-18 ZA ZA00772990A patent/ZA772990B/xx unknown
- 1977-05-18 LU LU77365A patent/LU77365A1/xx unknown
- 1977-05-18 NZ NZ184140A patent/NZ184140A/xx unknown
- 1977-05-19 JP JP5712877A patent/JPS5315428A/ja active Pending
- 1977-05-20 IE IE1039/77A patent/IE45200B1/en unknown
- 1977-05-20 NL NL7705561A patent/NL7705561A/xx not_active Application Discontinuation
- 1977-05-20 NO NO771766A patent/NO771766L/no unknown
- 1977-05-20 DE DE19772722916 patent/DE2722916A1/de not_active Withdrawn
- 1977-05-20 DK DK223377A patent/DK223377A/da not_active Application Discontinuation
-
1979
- 1979-03-05 US US06/017,422 patent/US4269853A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL52103A0 (en) | 1977-07-31 |
| ZA772990B (en) | 1978-04-26 |
| GB1560489A (en) | 1980-02-06 |
| IL52103A (en) | 1981-09-13 |
| FR2361387B1 (OSRAM) | 1980-05-09 |
| DE2722916A1 (de) | 1977-12-01 |
| AU2519677A (en) | 1978-11-23 |
| DK223377A (da) | 1977-11-22 |
| US4269853A (en) | 1981-05-26 |
| IE45200B1 (en) | 1982-07-14 |
| JPS5315428A (en) | 1978-02-13 |
| NZ184140A (en) | 1978-06-20 |
| AU508191B2 (en) | 1980-03-13 |
| FI771582A7 (OSRAM) | 1977-11-22 |
| BE854691A (fr) | 1977-11-16 |
| IE45200L (en) | 1977-11-21 |
| LU77365A1 (OSRAM) | 1977-12-13 |
| NL7705561A (nl) | 1977-11-23 |
| NO771766L (no) | 1977-11-22 |
| SE7705851L (sv) | 1977-11-22 |
| FR2361387A1 (fr) | 1978-03-10 |
| US4160844A (en) | 1979-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |