CA1072569A - Pellet form medicament - Google Patents
Pellet form medicamentInfo
- Publication number
- CA1072569A CA1072569A CA232,477A CA232477A CA1072569A CA 1072569 A CA1072569 A CA 1072569A CA 232477 A CA232477 A CA 232477A CA 1072569 A CA1072569 A CA 1072569A
- Authority
- CA
- Canada
- Prior art keywords
- medicament
- soft
- pellets
- microns
- pellet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008188 pellet Substances 0.000 title claims abstract description 106
- 239000003814 drug Substances 0.000 title claims abstract description 56
- 239000002245 particle Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 20
- 238000005054 agglomeration Methods 0.000 claims abstract description 12
- 230000002776 aggregation Effects 0.000 claims abstract description 12
- 239000002775 capsule Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 229960000265 cromoglicic acid Drugs 0.000 claims description 7
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 7
- 239000002002 slurry Substances 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 2
- 208000028004 allergic respiratory disease Diseases 0.000 claims 3
- 239000000843 powder Substances 0.000 description 18
- 239000000463 material Substances 0.000 description 14
- 238000005243 fluidization Methods 0.000 description 12
- 239000011230 binding agent Substances 0.000 description 7
- 238000013019 agitation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000001427 coherent effect Effects 0.000 description 4
- 239000010419 fine particle Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 3
- 239000001828 Gelatine Substances 0.000 description 3
- 101000852483 Homo sapiens Interleukin-1 receptor-associated kinase 1 Proteins 0.000 description 3
- 102100036342 Interleukin-1 receptor-associated kinase 1 Human genes 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- ZOLBALGTFCCTJF-UHFFFAOYSA-N 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;sulfuric acid Chemical compound OS(O)(=O)=O.CC(C)NCC(O)C1=CC=C(O)C(O)=C1.CC(C)NCC(O)C1=CC=C(O)C(O)=C1 ZOLBALGTFCCTJF-UHFFFAOYSA-N 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 208000035126 Facies Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000724182 Macron Species 0.000 description 1
- 241000353097 Molva molva Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- -1 colourants Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- HGYBWKSFVPDKOX-UHFFFAOYSA-L disodium;7-[3-(2-carboxylato-4-oxochromen-7-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C=2C1=CC(OCC(COC=1C=C3C(C(C=C(O3)C([O-])=O)=O)=CC=1)O)=CC=2 HGYBWKSFVPDKOX-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229940047135 glycate Drugs 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB35334/74A GB1520247A (en) | 1974-08-10 | 1974-08-10 | Pelletised medicament formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1072569A true CA1072569A (en) | 1980-02-26 |
Family
ID=10376566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA232,477A Expired CA1072569A (en) | 1974-08-10 | 1975-07-29 | Pellet form medicament |
Country Status (21)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795646A (en) * | 1986-10-24 | 1989-01-03 | Cl Pharma Aktiengesellschaft | Process for the preparation of binder-free, tablettable granules of celiprolol hydrochloride |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2741202A1 (de) * | 1976-09-23 | 1978-03-30 | Fisons Ltd | Dinatriumcromoglycat mit besonderer massendichte |
| JPS6034925B2 (ja) * | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
| GB8911259D0 (en) * | 1989-05-17 | 1989-07-05 | Fisons Plc | Inhalation medicament |
| US5198221A (en) * | 1989-05-17 | 1993-03-30 | Fisons Plc | Pharmaceutical composition |
| GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
| US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| IS1736B (is) | 1993-10-01 | 1999-12-30 | Astra Ab | Aðferð og tæki sem stuðla að aukinni samloðun agna |
| EP0721331B1 (en) * | 1993-10-01 | 2001-12-05 | AstraZeneca AB | Process i |
| US6165976A (en) | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
| DE4425255A1 (de) | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| MX9704544A (es) | 1994-12-22 | 1997-10-31 | Astra Aktebolag | Preparacion terapeutica para inalacion que contiene hormona paratiroidea, pth. |
| HUT77775A (hu) | 1994-12-22 | 1998-08-28 | Astra Aktiebolag | Aeroszolformák |
| TWI225402B (en) | 1996-03-13 | 2004-12-21 | Biochemie Gmbh | Auxiliary-free agglomerates |
| US6503537B2 (en) | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
| DE69840277D1 (de) | 1997-03-20 | 2009-01-08 | Schering Corp | Dosierungsform eines Pulveragglomerates |
| US6495167B2 (en) | 1997-03-20 | 2002-12-17 | Schering Corporation | Preparation of powder agglomerates |
| US6623760B1 (en) | 1999-01-28 | 2003-09-23 | Schering Corporation | Method of preparing particles for agglomeration |
| ITMI991582A1 (it) | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0009469D0 (en) | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812574A1 (de) * | 1968-12-04 | 1970-06-11 | Riedel De Haen Ag | Verfahren zur Herstellung biozider Granulate |
| GB1381872A (en) * | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
-
1974
- 1974-08-10 GB GB35334/74A patent/GB1520247A/en not_active Expired
-
1975
- 1975-07-23 ZA ZA00754765A patent/ZA754765B/xx unknown
- 1975-07-23 IE IE1645/75A patent/IE41586B1/en not_active IP Right Cessation
- 1975-07-24 CY CY1049A patent/CY1049A/xx unknown
- 1975-07-28 IL IL47829A patent/IL47829A/xx unknown
- 1975-07-29 CA CA232,477A patent/CA1072569A/en not_active Expired
- 1975-07-30 NL NLAANVRAGE7509080,A patent/NL177980C/xx not_active IP Right Cessation
- 1975-07-31 AR AR259849A patent/AR210997A1/es active
- 1975-08-04 BE BE158922A patent/BE832097A/xx not_active IP Right Cessation
- 1975-08-06 FI FI752232A patent/FI65547C/fi not_active IP Right Cessation
- 1975-08-07 BR BR7505055*A patent/BR7505055A/pt unknown
- 1975-08-07 FR FR7524631A patent/FR2282259A1/fr active Granted
- 1975-08-08 DK DK360875A patent/DK145654C/da not_active IP Right Cessation
- 1975-08-08 HU HU75FI596A patent/HU175594B/hu unknown
- 1975-08-08 LU LU73182A patent/LU73182A1/xx unknown
- 1975-08-08 NO NO752786A patent/NO146660C/no unknown
- 1975-08-08 SE SE7508967A patent/SE440595B/xx not_active IP Right Cessation
- 1975-08-11 JP JP50096732A patent/JPS5910326B2/ja not_active Expired
-
1980
- 1980-03-10 KE KE3034A patent/KE3034A/xx unknown
- 1980-04-03 HK HK177/80A patent/HK17780A/xx unknown
-
1981
- 1981-12-30 MY MY34/81A patent/MY8100034A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795646A (en) * | 1986-10-24 | 1989-01-03 | Cl Pharma Aktiengesellschaft | Process for the preparation of binder-free, tablettable granules of celiprolol hydrochloride |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |