CA1065317A - Catalytic dehalogenation process for preparing 2-(4- (2- furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline - Google Patents

Catalytic dehalogenation process for preparing 2-(4- (2- furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

Info

Publication number
CA1065317A
CA1065317A CA281,453A CA281453A CA1065317A CA 1065317 A CA1065317 A CA 1065317A CA 281453 A CA281453 A CA 281453A CA 1065317 A CA1065317 A CA 1065317A
Authority
CA
Canada
Prior art keywords
formula
furoyl
bromo
amino
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA281,453A
Other languages
English (en)
French (fr)
Inventor
Philip D. Hammen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of CA1065317A publication Critical patent/CA1065317A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cephalosporin Compounds (AREA)
CA281,453A 1976-08-06 1977-06-27 Catalytic dehalogenation process for preparing 2-(4- (2- furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline Expired CA1065317A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71227776A 1976-08-06 1976-08-06

Publications (1)

Publication Number Publication Date
CA1065317A true CA1065317A (en) 1979-10-30

Family

ID=24861452

Family Applications (1)

Application Number Title Priority Date Filing Date
CA281,453A Expired CA1065317A (en) 1976-08-06 1977-06-27 Catalytic dehalogenation process for preparing 2-(4- (2- furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

Country Status (29)

Country Link
JP (1) JPS5321181A (es)
AR (1) AR213317A1 (es)
BE (1) BE857491A (es)
CA (1) CA1065317A (es)
CH (1) CH633794A5 (es)
CS (1) CS202074B2 (es)
DD (1) DD131855A5 (es)
DE (1) DE2731737A1 (es)
DK (1) DK143601C (es)
ES (1) ES460685A1 (es)
FI (1) FI65999C (es)
FR (1) FR2360591A1 (es)
GB (1) GB1526180A (es)
GR (1) GR69201B (es)
HK (1) HK30281A (es)
HU (1) HU177714B (es)
IE (1) IE45776B1 (es)
IL (1) IL52394A0 (es)
LU (1) LU77925A1 (es)
MY (1) MY8100264A (es)
NL (1) NL171448C (es)
NO (1) NO147912C (es)
NZ (1) NZ184535A (es)
PL (1) PL104355B1 (es)
PT (1) PT66796B (es)
RO (1) RO73523A (es)
SE (2) SE436032B (es)
YU (1) YU39397B (es)
ZA (1) ZA773898B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793977A (en) * 1980-11-26 1982-06-11 Sankyo Co Ltd Acylaminoquinazoline derivative and its preparation

Also Published As

Publication number Publication date
CS202074B2 (en) 1980-12-31
CH633794A5 (en) 1982-12-31
DE2731737A1 (de) 1978-02-09
NL171448C (nl) 1983-04-05
HU177714B (en) 1981-12-28
IL52394A0 (en) 1977-08-31
NO772488L (no) 1978-02-07
NO147912C (no) 1983-07-06
PL104355B1 (pl) 1979-08-31
YU39397B (en) 1984-12-31
DK143601B (da) 1981-09-14
FR2360591A1 (fr) 1978-03-03
NL171448B (nl) 1982-11-01
NL7707792A (nl) 1978-02-08
PT66796B (en) 1978-12-20
SE7707472L (sv) 1978-02-07
PT66796A (en) 1977-08-01
IE45776L (en) 1978-02-06
JPS5321181A (en) 1978-02-27
DK320077A (da) 1978-02-07
FI772193A (es) 1978-02-07
FI65999B (fi) 1984-04-30
FR2360591B1 (es) 1981-01-09
GR69201B (es) 1982-05-06
ZA773898B (en) 1978-05-30
ES460685A1 (es) 1978-07-01
MY8100264A (en) 1981-12-31
LU77925A1 (fr) 1979-05-23
SE436032B (sv) 1984-11-05
YU171577A (en) 1982-08-31
DK143601C (da) 1982-02-08
IE45776B1 (en) 1982-12-01
AR213317A1 (es) 1979-01-15
GB1526180A (en) 1978-09-27
RO73523A (ro) 1981-08-30
HK30281A (en) 1981-07-10
SE439162B (sv) 1985-06-03
FI65999C (fi) 1984-08-10
AU2663777A (en) 1978-04-27
DD131855A5 (de) 1978-07-26
PL200090A1 (pl) 1978-05-22
BE857491A (fr) 1978-02-06
NO147912B (no) 1983-03-28
SE8203583L (sv) 1982-06-09
NZ184535A (en) 1979-06-08

Similar Documents

Publication Publication Date Title
JP2024009810A (ja) Ｓｈｐ２の活性を阻害するための化合物及び組成物の製造
CN102295594B (zh) 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
JP2019527210A (ja) カリプラジンの工業的製造方法
CA1065317A (en) Catalytic dehalogenation process for preparing 2-(4- (2- furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
KR810001414B1 (ko) 2-〔4-(2-푸로일)피페라진-1-일〕-4-아미노-6,7-디메톡시 퀴나졸린의 제조방법
US5053513A (en) Method of reducing a carbonyl containing acridine
US4751298A (en) Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof
JP4591349B2 (ja) ４−アミノテトラヒドロピラン化合物及びその酸塩の製法、その合成中間体およびその製法
US20230374029A1 (en) Manufacture of compounds and compositions for inhibiting the activity of shp2
JPH0625191B2 (ja) １−［２−（フエニルメチル）フエニルピペラジン化合物、その製造方法および医薬組成物
Santangelo et al. Synthesis and positive inotropic effect of 1-alkyl-and 1-acyl-6, 7-dimethoxy-3-dimethylamino-1, 2, 3, 4-tetrahydroquinolines
RU2785543C1 (ru) 2,8-БИС-(5-МЕТИЛИЗОКСАЗОЛ-3-ИЛ ИЛИ 1,5-ДИМЕТИЛ-3-ОКСО-2-ФЕНИЛ-1,2-ДИГИДРО-3Н-ПИРАЗОЛ-4-ИЛ)-2,3,8,9,12c,12d-ГЕКСАГИДРО-1Н,7Н-5,11-ДИОКСА-2,3a.4,6,6b8,9a,10,12,12b-ДЕКААЗАДИЦИКЛОПЕНТА[e,l]ПИРЕНЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В КАЧЕСТВЕ СРЕДСТВ С ЦИТОТОКСИЧЕСКОЙ АКТИВНОСТЬЮ
JPS5813540B2 (ja) １，２，３，４− テトラヒドロイソキノリンルイノ セイゾウホウ
EP1087954A1 (en) Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US2651635A (en) Preparation of 1-benzyl-1:2:3:4:5:6:7:8-octahydro-isoquinoline
Kawe et al. Synthesis of Benzofuro [2, 3-b] benzofuran Derivatives under Hoesch Reaction Conditions
EP2016052B1 (en) Crystalline (3-cyano-1h-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate
RU2333908C1 (ru) Способ получения 2-этил-3,5-диметилпиридина
JPS5993050A (ja) カルボスチリル誘導体の製造法
KR900002054B1 (ko) 퀴놀론 유도체의 제조방법
CA1074305A (en) Amino-substituted tetracyclic compounds
Boháč et al. Acetylation of 2-Acyl-1, 3-indandiones with Ketene and Determination of the Structure of Products
DK144475B (da) I furoylgruppen halogen-substituerede 2-(4-(2-furoyl) piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoliner til brug som mellemprodukter ved fremstilling af 2-(4-(2-furoyl)-piperazin-1-yl)-4-amino-6,7-dimathoxyquinazolin eller hydrochloridet hydrobromidet eller hydroiodidet deraf
PL152958B1 (en) Method for manufacturing piperazine derivatives
JPS62286980A (ja) フエニルピペラジン誘導体