CA1065315A - Process for producing nucleosides - Google Patents
Process for producing nucleosidesInfo
- Publication number
- CA1065315A CA1065315A CA246,368A CA246368A CA1065315A CA 1065315 A CA1065315 A CA 1065315A CA 246368 A CA246368 A CA 246368A CA 1065315 A CA1065315 A CA 1065315A
- Authority
- CA
- Canada
- Prior art keywords
- tri
- process according
- beta
- benzoyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752508312 DE2508312A1 (de) | 1975-02-24 | 1975-02-24 | Neues verfahren zur herstellung von nucleosiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1065315A true CA1065315A (en) | 1979-10-30 |
Family
ID=5939872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA246,368A Expired CA1065315A (en) | 1975-02-24 | 1976-02-23 | Process for producing nucleosides |
Country Status (12)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53108986A (en) * | 1977-03-02 | 1978-09-22 | Mitsui Toatsu Chem Inc | Preparation of nucleosides and nucleotides |
| DE2721466A1 (de) * | 1977-05-12 | 1978-11-16 | Robugen Gmbh | Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden |
| US4195176A (en) * | 1977-10-11 | 1980-03-25 | Warner-Lambert Company | Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazol[4,5-d][1,3]diazepin-8-ol |
| DE2757365A1 (de) * | 1977-12-20 | 1979-06-21 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| JPH029511U (US07608600-20091027-C00048.png) * | 1988-06-21 | 1990-01-22 | ||
| CA2091732C (en) * | 1992-07-08 | 1998-07-21 | Anica Markovac | A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine |
| JPH07276137A (ja) * | 1994-03-31 | 1995-10-24 | Osaka Diamond Ind Co Ltd | 切削・研削用工具 |
| DE19513330A1 (de) * | 1995-04-03 | 1996-10-10 | Schering Ag | Neues Verfahren zur Herstellung von Nucleosiden |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CN1315862C (zh) | 2000-05-26 | 2007-05-16 | 艾登尼科斯（开曼）有限公司 | 处理黄病毒和瘟病毒的方法和组合物 |
| US7456155B2 (en) | 2002-06-28 | 2008-11-25 | Idenix Pharmaceuticals, Inc. | 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| EP1576138B1 (en) | 2002-11-15 | 2017-02-01 | Idenix Pharmaceuticals LLC. | 2'-methyl nucleosides in combination with interferon and flaviviridae mutation |
| US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US7038038B2 (en) * | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
| US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US7595390B2 (en) | 2003-04-28 | 2009-09-29 | Novartis Ag | Industrially scalable nucleoside synthesis |
| NZ544634A (en) | 2003-06-30 | 2009-10-30 | Idenix Cayman Ltd | Synthesis of beta-l-2-deoxy nucleosides |
| AT502635A1 (de) * | 2005-11-09 | 2007-05-15 | Saischek Und Partner Meg | Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung |
| EP1976382B1 (en) | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| EP2048151A1 (en) | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
| EP2050757A1 (en) * | 2007-10-10 | 2009-04-22 | Cilag AG | Method of producing 2' -deoxy-5-azacytidine (Decitabine) |
| BRPI0912717A2 (pt) | 2008-05-15 | 2014-12-23 | Celgene Corp | Composição farmacêutica, e, uso de 5-azacitidina |
| EP2321302B1 (en) * | 2008-08-01 | 2014-10-29 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| ES2400779T3 (es) * | 2008-08-06 | 2013-04-12 | Sicor, Inc. | Proceso para preparar un producto intermedio de azacitidina |
| CA2733591C (en) * | 2008-08-08 | 2016-06-28 | Scinopharm Taiwan Ltd. | Process for making 5-azacytosine nucleosides and their derivatives |
| EP2424845A4 (en) * | 2009-04-27 | 2014-03-05 | Reddys Lab Ltd Dr | PREPARATION OF DECITABIN |
| BR112013025167A2 (pt) | 2011-03-31 | 2019-09-24 | Celgene Int Sarl | processo para preparar 5-azacitidina, ou um sal, solvato, hidrato, ou seu polimorfo, sal de 5-azacitidina, 5-azacitidina, ou um sal, solvato, hidrato, ou polimorfo |
| CN108239128B (zh) * | 2016-12-23 | 2019-03-29 | 江苏奥赛康药业股份有限公司 | β-核苷类化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354160A (en) * | 1965-07-22 | 1967-11-21 | Hoffmann La Roche | Tri-lower alkyl-silyl-5-fluoropyrimidines |
| US3352849A (en) * | 1965-10-24 | 1967-11-14 | Merck & Co Inc | 6-aza-2'-deoxyuridines |
| SU452961A3 (ru) * | 1969-04-11 | 1974-12-05 | Шеринг Аг. (Фирма) | Способ получени пиримидиннуклеозидов |
| DE2122991C2 (de) * | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
-
1975
- 1975-02-24 DE DE19752508312 patent/DE2508312A1/de active Granted
-
1976
- 1976-02-18 NL NL7601625A patent/NL7601625A/xx not_active Application Discontinuation
- 1976-02-23 SE SE7602109A patent/SE7602109L/xx unknown
- 1976-02-23 US US05/660,675 patent/US4082911A/en not_active Expired - Lifetime
- 1976-02-23 GB GB767006A patent/GB1542442A/en not_active Expired
- 1976-02-23 LU LU74411A patent/LU74411A1/xx unknown
- 1976-02-23 CA CA246,368A patent/CA1065315A/en not_active Expired
- 1976-02-24 FR FR7605030A patent/FR2301536A1/fr active Granted
- 1976-02-24 JP JP51019810A patent/JPS51125382A/ja active Granted
- 1976-02-24 CH CH227476A patent/CH626093A5/de not_active IP Right Cessation
- 1976-02-24 DK DK77176A patent/DK138900C/da active
- 1976-02-24 BE BE164585A patent/BE838879A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LU74411A1 (US07608600-20091027-C00048.png) | 1976-08-13 |
| DE2508312A1 (de) | 1976-09-02 |
| GB1542442A (en) | 1979-03-21 |
| DK77176A (da) | 1976-08-25 |
| FR2301536A1 (fr) | 1976-09-17 |
| JPS51125382A (en) | 1976-11-01 |
| US4082911A (en) | 1978-04-04 |
| NL7601625A (nl) | 1976-08-26 |
| JPS6139318B2 (US07608600-20091027-C00048.png) | 1986-09-03 |
| DE2508312C2 (US07608600-20091027-C00048.png) | 1987-10-29 |
| CH626093A5 (US07608600-20091027-C00048.png) | 1981-10-30 |
| FR2301536B1 (US07608600-20091027-C00048.png) | 1979-07-27 |
| SE7602109L (sv) | 1976-08-25 |
| DK138900C (da) | 1979-04-30 |
| DK138900B (da) | 1978-11-13 |
| BE838879A (fr) | 1976-08-24 |
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