CA1059988A - Process for the manufacture of enol derivatives - Google Patents

Process for the manufacture of enol derivatives

Info

Publication number
CA1059988A
CA1059988A CA220,745A CA220745A CA1059988A CA 1059988 A CA1059988 A CA 1059988A CA 220745 A CA220745 A CA 220745A CA 1059988 A CA1059988 A CA 1059988A
Authority
CA
Canada
Prior art keywords
lower alkyl
phenoxyacetamido
formula
methoxy
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA220,745A
Other languages
English (en)
French (fr)
Other versions
CA220745S (en
Inventor
Robert B. Woodward
Hans Bickel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/de
Priority claimed from CH776674A external-priority patent/CH610584A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of CA1059988A publication Critical patent/CA1059988A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA220,745A 1974-02-26 1975-02-25 Process for the manufacture of enol derivatives Expired CA1059988A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
CA1059988A true CA1059988A (en) 1979-08-07

Family

ID=27173851

Family Applications (2)

Application Number Title Priority Date Filing Date
CA220,745A Expired CA1059988A (en) 1974-02-26 1975-02-25 Process for the manufacture of enol derivatives
CA325,019A Expired CA1080713A (en) 1974-02-26 1979-04-06 Process for the manufacture of 3-substituted-hydroxy-crotonic and isocrotonic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA325,019A Expired CA1080713A (en) 1974-02-26 1979-04-06 Process for the manufacture of 3-substituted-hydroxy-crotonic and isocrotonic acid derivatives

Country Status (21)

Country Link
JP (1) JPS625919B2 (en, 2012)
AR (1) AR208538A1 (en, 2012)
AT (2) AT337362B (en, 2012)
AU (1) AU498131B2 (en, 2012)
BE (1) BE825919A (en, 2012)
BG (1) BG26201A3 (en, 2012)
CA (2) CA1059988A (en, 2012)
DD (1) DD117074A5 (en, 2012)
DE (1) DE2506330A1 (en, 2012)
DK (2) DK73475A (en, 2012)
ES (2) ES435110A1 (en, 2012)
FI (1) FI66389C (en, 2012)
FR (1) FR2261761B1 (en, 2012)
GB (1) GB1503581A (en, 2012)
HU (1) HU175212B (en, 2012)
IE (1) IE40695B1 (en, 2012)
IL (1) IL46699A (en, 2012)
NL (1) NL7502292A (en, 2012)
NO (1) NO750625L (en, 2012)
NZ (1) NZ176623A (en, 2012)
SE (3) SE431652B (en, 2012)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (it) * 1974-08-02 1980-03-20 Farmaceutici Italia Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
JPS5198265A (en, 2012) * 1975-02-17 1976-08-30
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
US4301279A (en) 1979-02-23 1981-11-17 Ciba-Geigy Corporation Process for the production of 3-hydroxy compounds
JPH0639474B2 (ja) * 1983-03-04 1994-05-25 大塚化学株式会社 セファロスポリン化合物の製造法
JPS59228854A (ja) * 1983-06-08 1984-12-22 真井　康博 薬液収納兼即効注出器
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60126263A (ja) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法
JP2006507289A (ja) * 2002-11-01 2006-03-02 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド 改良されたクロロメチルセフェム誘導体調製方法
CN108409820A (zh) 2011-12-20 2018-08-17 里博科学有限责任公司 作为hcv rna复制抑制剂的4′-叠氮基，3′-氟取代的核苷衍生物
BR112014013661B1 (pt) 2011-12-20 2020-10-27 Riboscience Llc. Derivados de nucleosídeos 2,4-difluoro-2-metil substituídos como inibidores de replicação de hcv-rna
JP2016519146A (ja) 2013-05-16 2016-06-30 リボサイエンス・エルエルシー ４’−アジド，３’−デオキシ−３’−フルオロ置換ヌクレオシド誘導体
PE20160120A1 (es) 2013-05-16 2016-02-24 Riboscience Llc Derivados de nucleosido 4'-fluoro-2'-metilo sustituido
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
IL273398B2 (en) 2017-09-21 2025-02-01 Riboscience Llc History of 4'-fluoro-2'-methyl-modified nucleosides as inhibitors of HCV RNA replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos

Also Published As

Publication number Publication date
JPS50129590A (en, 2012) 1975-10-13
DK73475A (en, 2012) 1975-10-20
ATA108275A (de) 1976-10-15
IL46699A (en) 1977-11-30
ES435110A1 (es) 1977-03-16
IE40695L (en) 1975-08-26
JPS625919B2 (en, 2012) 1987-02-07
FR2261761A1 (en, 2012) 1975-09-19
DE2506330A1 (de) 1975-09-04
BE825919A (fr) 1975-08-25
SE7807811L (sv) 1978-07-13
NO750625L (en, 2012) 1975-08-27
SE431652B (sv) 1984-02-20
GB1503581A (en) 1978-03-15
FI66389B (fi) 1984-06-29
DK348678A (da) 1978-08-07
SE438855B (sv) 1985-05-13
ES452915A1 (es) 1977-11-01
FI750503A7 (en, 2012) 1975-08-27
AT350068B (de) 1979-05-10
FR2261761B1 (en, 2012) 1978-08-18
NZ176623A (en) 1978-04-03
FI66389C (fi) 1984-10-10
SE7501317L (en, 2012) 1975-08-27
SE7807810L (sv) 1978-07-13
IL46699A0 (en) 1975-04-25
HU175212B (hu) 1980-06-28
AT337362B (de) 1977-06-27
BG26201A3 (bg) 1979-02-15
AU7849875A (en) 1976-08-26
ATA28178A (de) 1978-10-15
NL7502292A (nl) 1975-08-28
AR208538A1 (es) 1977-02-15
SE438854B (sv) 1985-05-13
AU498131B2 (en) 1979-02-15
CA1080713A (en) 1980-07-01
DD117074A5 (en, 2012) 1975-12-20
IE40695B1 (en) 1979-08-01

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