CA1058538A - Enzyme bound to polymer which is entrapped in inorganic carrier - Google Patents
Enzyme bound to polymer which is entrapped in inorganic carrierInfo
- Publication number
- CA1058538A CA1058538A CA245,940A CA245940A CA1058538A CA 1058538 A CA1058538 A CA 1058538A CA 245940 A CA245940 A CA 245940A CA 1058538 A CA1058538 A CA 1058538A
- Authority
- CA
- Canada
- Prior art keywords
- set forth
- immobilized enzyme
- enzyme conjugate
- organic
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 127
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 127
- 229920000642 polymer Polymers 0.000 title claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 59
- 239000011159 matrix material Substances 0.000 claims abstract description 32
- 239000011148 porous material Substances 0.000 claims abstract description 28
- 239000000203 mixture Substances 0.000 claims abstract description 26
- 108010093096 Immobilized Enzymes Proteins 0.000 claims abstract description 25
- 239000000178 monomer Substances 0.000 claims abstract description 23
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 230000001588 bifunctional effect Effects 0.000 claims abstract description 16
- 238000011065 in-situ storage Methods 0.000 claims abstract description 6
- 229940088598 enzyme Drugs 0.000 claims description 125
- 238000000034 method Methods 0.000 claims description 42
- 239000000243 solution Substances 0.000 claims description 40
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 22
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 14
- 239000002131 composite material Substances 0.000 claims description 14
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 10
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- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 8
- 102100022624 Glucoamylase Human genes 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
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- 239000004366 Glucose oxidase Substances 0.000 claims description 5
- 108010015776 Glucose oxidase Proteins 0.000 claims description 5
- 108091005804 Peptidases Proteins 0.000 claims description 5
- YZYDPPZYDIRSJT-UHFFFAOYSA-K boron phosphate Chemical compound [B+3].[O-]P([O-])([O-])=O YZYDPPZYDIRSJT-UHFFFAOYSA-K 0.000 claims description 5
- 229910000149 boron phosphate Inorganic materials 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 5
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- 108010005774 beta-Galactosidase Proteins 0.000 claims description 3
- 229940116108 lactase Drugs 0.000 claims description 3
- 229920002873 Polyethylenimine Polymers 0.000 claims description 2
- 108700040099 Xylose isomerases Proteins 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
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- LSHROXHEILXKHM-UHFFFAOYSA-N n'-[2-[2-[2-(2-aminoethylamino)ethylamino]ethylamino]ethyl]ethane-1,2-diamine Chemical compound NCCNCCNCCNCCNCCN LSHROXHEILXKHM-UHFFFAOYSA-N 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
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- 108090000526 Papain Proteins 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
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- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 3
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- 238000004132 cross linking Methods 0.000 description 3
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- 229920000768 polyamine Polymers 0.000 description 3
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- 239000012588 trypsin Substances 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 2
- 102100034866 Kallikrein-6 Human genes 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108010059712 Pronase Proteins 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
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- 235000013351 cheese Nutrition 0.000 description 2
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- 235000013305 food Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
- 229910021432 inorganic complex Inorganic materials 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
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- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229910000077 silane Inorganic materials 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 description 1
- YBRVSVVVWCFQMG-UHFFFAOYSA-N 4,4'-diaminodiphenylmethane Chemical compound C1=CC(N)=CC=C1CC1=CC=C(N)C=C1 YBRVSVVVWCFQMG-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102100033639 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
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- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 241000511343 Chondrostoma nasus Species 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- 241000698776 Duma Species 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 108090000270 Ficain Proteins 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 101100519432 Rattus norvegicus Pdzd2 gene Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 101100536893 Schizosaccharomyces pombe (strain 972 / ATCC 24843) thi9 gene Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000950638 Symphysodon discus Species 0.000 description 1
- 241000193803 Therea Species 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- PWAXUOGZOSVGBO-UHFFFAOYSA-N adipoyl chloride Chemical compound ClC(=O)CCCCC(Cl)=O PWAXUOGZOSVGBO-UHFFFAOYSA-N 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
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- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
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- WMPOZLHMGVKUEJ-UHFFFAOYSA-N decanedioyl dichloride Chemical compound ClC(=O)CCCCCCCCC(Cl)=O WMPOZLHMGVKUEJ-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000019836 ficin Nutrition 0.000 description 1
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
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- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
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- 229910003480 inorganic solid Inorganic materials 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
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- 235000013372 meat Nutrition 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- YNDRMAAWTXUJPV-UHFFFAOYSA-N n-cyclohexyl-2-methylidenecyclohexan-1-amine Chemical compound C=C1CCCCC1NC1CCCCC1 YNDRMAAWTXUJPV-UHFFFAOYSA-N 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
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- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/091—Phenol resins; Amino resins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0254—Nitrogen containing compounds on mineral substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/06—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/093—Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55089875A | 1975-02-18 | 1975-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1058538A true CA1058538A (en) | 1979-07-17 |
Family
ID=24199032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA245,940A Expired CA1058538A (en) | 1975-02-18 | 1976-02-17 | Enzyme bound to polymer which is entrapped in inorganic carrier |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS571988B2 (cs) |
| AR (1) | AR215240A1 (cs) |
| AT (1) | AT363890B (cs) |
| AU (1) | AU497243B2 (cs) |
| BE (1) | BE838684A (cs) |
| BR (1) | BR7600989A (cs) |
| CA (1) | CA1058538A (cs) |
| CH (1) | CH634876A5 (cs) |
| CS (1) | CS209424B2 (cs) |
| DD (1) | DD123346A5 (cs) |
| DE (1) | DE2605797C3 (cs) |
| DK (1) | DK145104C (cs) |
| EG (1) | EG11923A (cs) |
| ES (1) | ES445248A1 (cs) |
| FR (1) | FR2301533A1 (cs) |
| GB (1) | GB1537086A (cs) |
| IE (1) | IE42482B1 (cs) |
| IT (1) | IT1055978B (cs) |
| LU (1) | LU74379A1 (cs) |
| NL (1) | NL7601580A (cs) |
| NO (1) | NO148600C (cs) |
| PL (1) | PL102119B1 (cs) |
| PT (1) | PT64790B (cs) |
| SE (1) | SE434064B (cs) |
| YU (1) | YU37476A (cs) |
| ZA (1) | ZA76871B (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335017A (en) | 1975-12-15 | 1982-06-15 | United Kingdom Atomic Energy Authority | Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography |
| DE2636206C3 (de) * | 1976-08-12 | 1981-06-04 | C.H. Boehringer Sohn, 6507 Ingelheim | Trägerfixierte Enzyme sowie ihre Herstellung und Anwendung |
| CA1128917A (en) * | 1978-10-16 | 1982-08-03 | Ronald P. Rohrbach | Support matrices for immobilized enzymes |
| FR2531452B1 (fr) * | 1982-08-05 | 1985-06-28 | Uop Inc | Matrice de support magnetique et systeme a enzyme immobilisee en comportant application |
| US4539294A (en) * | 1982-09-30 | 1985-09-03 | Akzona Incorporated | Immobilization of proteins on polymeric supports |
| NZ618950A (en) | 2009-05-20 | 2015-05-29 | Xyleco Inc | Bioprocessing |
| CN117402234A (zh) * | 2023-09-27 | 2024-01-16 | 重庆芳禾生物科技有限公司 | 一种去除胃蛋白酶残留的胶原蛋白提取工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3556945A (en) * | 1968-02-05 | 1971-01-19 | Corning Glass Works | Enzyme stabilization |
| CH538003A (fr) * | 1968-03-29 | 1973-01-31 | Anvar | Procédé pour l'obtention d'articles textiles porteurs d'enzymes |
| GB1238280A (cs) * | 1968-11-06 | 1971-07-07 | ||
| US3715278A (en) * | 1970-02-11 | 1973-02-06 | Monsanto Co | Enzyme-polymer product attached to surface of siliceous materials thereof |
| US3796634A (en) * | 1970-03-19 | 1974-03-12 | Us Health Education & Welfare | Insolubilized biologically active enzymes |
| CH533139A (fr) * | 1971-06-21 | 1973-01-31 | Nestle Sa | Procédé de préparation d'un produit doué d'activité enzymatique, insoluble en milieu aqueux |
| US3802909A (en) * | 1971-11-09 | 1974-04-09 | American Hospital Supply Corp | Bonding of organic materials to inorganic particles |
| GB1484565A (en) * | 1972-07-13 | 1977-09-01 | Koch Light Labor Ltd | Binding of biologically active macromolecules |
| GB1444539A (en) * | 1972-09-11 | 1976-08-04 | Novo Industri As | Immobilised enzymes |
| CH579109A5 (cs) * | 1973-02-22 | 1976-08-31 | Givaudan & Cie Sa | |
| SE7410542L (sv) * | 1974-01-29 | 1976-01-12 | Givaudan & Cie Sa | Kondensationsprodukter. |
-
1976
- 1976-02-12 PT PT64790A patent/PT64790B/pt unknown
- 1976-02-13 ZA ZA871A patent/ZA76871B/xx unknown
- 1976-02-13 DE DE2605797A patent/DE2605797C3/de not_active Expired
- 1976-02-16 CH CH187576A patent/CH634876A5/de not_active IP Right Cessation
- 1976-02-17 CA CA245,940A patent/CA1058538A/en not_active Expired
- 1976-02-17 FR FR7604271A patent/FR2301533A1/fr active Granted
- 1976-02-17 BR BR7600989A patent/BR7600989A/pt unknown
- 1976-02-17 AU AU11173/76A patent/AU497243B2/en not_active Expired
- 1976-02-17 GB GB6118/76A patent/GB1537086A/en not_active Expired
- 1976-02-17 DK DK63776A patent/DK145104C/da not_active IP Right Cessation
- 1976-02-17 SE SE7601757A patent/SE434064B/xx not_active IP Right Cessation
- 1976-02-17 NO NO760511A patent/NO148600C/no unknown
- 1976-02-17 NL NL7601580A patent/NL7601580A/xx active Search and Examination
- 1976-02-17 DD DD191282A patent/DD123346A5/xx unknown
- 1976-02-17 CS CS761011A patent/CS209424B2/cs unknown
- 1976-02-17 PL PL1976187276A patent/PL102119B1/pl unknown
- 1976-02-17 ES ES445248A patent/ES445248A1/es not_active Expired
- 1976-02-17 YU YU00374/76A patent/YU37476A/xx unknown
- 1976-02-18 IE IE317/76A patent/IE42482B1/en unknown
- 1976-02-18 BE BE164417A patent/BE838684A/xx not_active IP Right Cessation
- 1976-02-18 AR AR262289A patent/AR215240A1/es active
- 1976-02-18 JP JP1608176A patent/JPS571988B2/ja not_active Expired
- 1976-02-18 LU LU74379A patent/LU74379A1/xx unknown
- 1976-02-18 EG EG101/76A patent/EG11923A/xx active
- 1976-02-18 IT IT20283/76A patent/IT1055978B/it active
- 1976-02-18 AT AT0116176A patent/AT363890B/de not_active IP Right Cessation
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