CA1057681A - Sulphonic acid salts of s-adenosilmethionine, process for the preparation thereof and therapeutic compositions containing them - Google Patents

Sulphonic acid salts of s-adenosilmethionine, process for the preparation thereof and therapeutic compositions containing them

Info

Publication number
CA1057681A
CA1057681A CA231,185A CA231185A CA1057681A CA 1057681 A CA1057681 A CA 1057681A CA 231185 A CA231185 A CA 231185A CA 1057681 A CA1057681 A CA 1057681A
Authority
CA
Canada
Prior art keywords
sam
acid
sulphonic
salts
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA231,185A
Other languages
English (en)
French (fr)
Other versions
CA231185S (en
Inventor
Alberto Fiecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORESEARCH-LIMITED PARTNERSHIP
Original Assignee
BIORESEARCH-LIMITED PARTNERSHIP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH-LIMITED PARTNERSHIP filed Critical BIORESEARCH-LIMITED PARTNERSHIP
Application granted granted Critical
Publication of CA1057681A publication Critical patent/CA1057681A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA231,185A 1974-07-12 1975-07-10 Sulphonic acid salts of s-adenosilmethionine, process for the preparation thereof and therapeutic compositions containing them Expired CA1057681A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2512874 1974-07-12

Publications (1)

Publication Number Publication Date
CA1057681A true CA1057681A (en) 1979-07-03

Family

ID=11215784

Family Applications (1)

Application Number Title Priority Date Filing Date
CA231,185A Expired CA1057681A (en) 1974-07-12 1975-07-10 Sulphonic acid salts of s-adenosilmethionine, process for the preparation thereof and therapeutic compositions containing them

Country Status (27)

Country Link
US (1) US4057686A (enEXAMPLES)
JP (1) JPS51125717A (enEXAMPLES)
AR (1) AR221676A1 (enEXAMPLES)
AT (1) AT366064B (enEXAMPLES)
AU (1) AU498365B2 (enEXAMPLES)
BE (1) BE831310A (enEXAMPLES)
CA (1) CA1057681A (enEXAMPLES)
CH (1) CH606085A5 (enEXAMPLES)
DD (1) DD118643A5 (enEXAMPLES)
DE (1) DE2530898A1 (enEXAMPLES)
DK (1) DK144946C (enEXAMPLES)
ES (1) ES439316A1 (enEXAMPLES)
FI (1) FI63037C (enEXAMPLES)
FR (1) FR2277590A1 (enEXAMPLES)
GB (1) GB1506640A (enEXAMPLES)
HU (1) HU170264B (enEXAMPLES)
IE (1) IE41421B1 (enEXAMPLES)
IL (1) IL47656A (enEXAMPLES)
NL (1) NL171987C (enEXAMPLES)
NO (1) NO142175C (enEXAMPLES)
NZ (1) NZ178014A (enEXAMPLES)
PL (1) PL94268B1 (enEXAMPLES)
RO (1) RO77525A (enEXAMPLES)
SE (1) SE420204B (enEXAMPLES)
SU (1) SU676169A3 (enEXAMPLES)
YU (1) YU39271B (enEXAMPLES)
ZA (1) ZA754167B (enEXAMPLES)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
US7667034B2 (en) 2004-06-23 2010-02-23 Orchid Chemicals & Pharmaceuticals Limited Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
JPS5428808A (en) * 1977-08-03 1979-03-03 Yamasa Shoyu Co Ltd Composition containing s-adenoyl-l-methionine and its preparation
JPS5596099A (en) * 1979-01-12 1980-07-21 Tanabe Seiyaku Co Ltd Production of s-adenosyl-l-methionine using enzyme
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137640B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1169772B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche per uso orale contenenti sali stabili della s-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
US4962451A (en) * 1985-11-07 1990-10-09 International Business Machines Corporation Cache-effective sort string generation method
ATE80165T1 (de) * 1987-10-09 1992-09-15 Vincenzo Zappia Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
FR2623396B1 (fr) * 1987-11-25 1990-03-30 Sanofi Sa Utilisation de l'ademetionine contre le vieillissement de la peau
IT1229477B (it) * 1989-03-13 1991-09-03 Bioresearch Spa Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
JPH02290896A (ja) * 1989-04-28 1990-11-30 Fuji Kagaku Kogyo Kk 新規なｓ―アデノシルメチオニン誘導体
JPH03123514U (enEXAMPLES) * 1990-03-27 1991-12-16
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US6635615B1 (en) * 1999-11-17 2003-10-21 Rolland F. Hebert Stable salts of S-adenosyl-l-methionine
DE10022856A1 (de) * 2000-05-10 2001-11-15 Basf Ag Therapeutische Kombination von Liponsäure und C1-Donoren zur Behandlung von Störungen des Zentralen Nervensystems
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
FR2823211A1 (fr) * 2001-04-10 2002-10-11 Virbac Sa Composition a base d'un polyphosphate de s-adenosyl-l-methionine et utilisations d'un tel polyphosphate
US6649753B2 (en) 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
WO2002102823A1 (en) * 2001-06-14 2002-12-27 Orchid Chemicals & Pharmaceuticals Limited Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US8063024B2 (en) * 2005-01-26 2011-11-22 University Of Manitoba Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
FR2884421B1 (fr) 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
EP2151498A3 (en) * 2005-04-20 2010-12-15 BASF Plant Science GmbH Expression cassettes for seed-preferential expression in plants
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CN101437934B (zh) 2006-05-10 2013-03-20 三菱瓦斯化学株式会社 含s-腺苷-l-甲硫氨酸的干燥酵母的制备方法以及口服用组合物
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
CN101677543A (zh) * 2007-01-31 2010-03-24 甲基化物科学国际有限公司 S-腺苷甲硫氨酸的延时释放药物制剂
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
EP2193787A1 (en) * 2008-12-02 2010-06-09 Giorgio Stramentinoli Formulations for systemic buccal delivery comprising s-adenosylmethionine, their preparation and use
US20110027342A1 (en) 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) * 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
WO2012139227A1 (en) 2011-04-15 2012-10-18 Scimar Ltd. Use of s-adenosylmethionine, vitamin e, and vitamin c for the prevention and treatment of cardiovascular dysfunction
CN102321136B (zh) * 2011-09-19 2014-10-22 北京化工大学 S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法
US9801896B2 (en) 2012-10-17 2017-10-31 Methylation Sciences International Srl Compositions comprising S-adenosylmethionine and a gallic acid ester
ES2824807T3 (es) 2013-01-16 2021-05-13 Hebert Sam E Llc Sales de indol-3-propionato estables de S-adenosil-L-metionina
RU2537556C1 (ru) * 2013-07-30 2015-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения соли адеметионина с хондроитинсульфокислотой
US12239623B2 (en) 2023-05-15 2025-03-04 Bonafide Health, Llc Sleep-improving compositions and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1803978C2 (de) * 1968-10-18 1985-05-02 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
US7667034B2 (en) 2004-06-23 2010-02-23 Orchid Chemicals & Pharmaceuticals Limited Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer

Also Published As

Publication number Publication date
ZA754167B (en) 1976-05-26
NO142175B (no) 1980-03-31
JPS51125717A (en) 1976-11-02
US4057686A (en) 1977-11-08
ES439316A1 (es) 1977-02-16
FR2277590A1 (fr) 1976-02-06
IE41421L (en) 1976-01-12
FI63037C (fi) 1983-04-11
RO77525A (ro) 1982-09-09
BE831310A (fr) 1975-11-03
DE2530898A1 (de) 1976-01-29
NZ178014A (en) 1978-03-06
PL94268B1 (enEXAMPLES) 1977-07-30
DD118643A5 (enEXAMPLES) 1976-03-12
NO142175C (no) 1980-07-09
YU39271B (en) 1984-10-31
NL171987B (nl) 1983-01-17
JPS5610920B2 (enEXAMPLES) 1981-03-11
YU174475A (en) 1982-08-31
FR2277590B1 (enEXAMPLES) 1978-07-28
CH606085A5 (enEXAMPLES) 1978-10-13
AU8295975A (en) 1977-01-13
SE7507966L (sv) 1976-01-13
SE420204B (sv) 1981-09-21
HU170264B (enEXAMPLES) 1977-05-28
ATA521275A (de) 1981-07-15
NO752499L (enEXAMPLES) 1976-01-13
DE2530898C2 (enEXAMPLES) 1988-08-11
DK144946B (da) 1982-07-12
AR221676A1 (es) 1981-03-13
DK315375A (da) 1976-01-13
IL47656A (en) 1978-04-30
NL7508316A (nl) 1976-01-14
FI63037B (fi) 1982-12-31
GB1506640A (en) 1978-04-05
NL171987C (nl) 1983-06-16
SU676169A3 (ru) 1979-07-25
AT366064B (de) 1982-03-10
AU498365B2 (en) 1979-03-08
IE41421B1 (en) 1980-01-02
IL47656A0 (en) 1975-10-15
DK144946C (da) 1982-12-06
FI751946A7 (enEXAMPLES) 1976-01-13

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