CA1054056A - Solid therapeutic preparation remaining in stomach - Google Patents
Solid therapeutic preparation remaining in stomachInfo
- Publication number
- CA1054056A CA1054056A CA221,903A CA221903A CA1054056A CA 1054056 A CA1054056 A CA 1054056A CA 221903 A CA221903 A CA 221903A CA 1054056 A CA1054056 A CA 1054056A
- Authority
- CA
- Canada
- Prior art keywords
- active ingredient
- stomach
- preparation
- coating
- solid therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 47
- 210000002784 stomach Anatomy 0.000 title claims abstract description 27
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 21
- 239000007787 solid Substances 0.000 title claims abstract description 20
- 239000004480 active ingredient Substances 0.000 claims abstract description 28
- 210000004051 gastric juice Anatomy 0.000 claims abstract description 24
- 239000011248 coating agent Substances 0.000 claims description 35
- 238000000576 coating method Methods 0.000 claims description 35
- 239000001856 Ethyl cellulose Substances 0.000 claims description 13
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 13
- 229920001249 ethyl cellulose Polymers 0.000 claims description 13
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- DHUZAAUGHUHIDS-ONEGZZNKSA-N Isomyristicin Chemical compound COC1=CC(\C=C\C)=CC2=C1OCO2 DHUZAAUGHUHIDS-ONEGZZNKSA-N 0.000 claims description 10
- 229960005439 propantheline bromide Drugs 0.000 claims description 10
- 108010010803 Gelatin Proteins 0.000 claims description 9
- 239000008273 gelatin Substances 0.000 claims description 9
- 229920000159 gelatin Polymers 0.000 claims description 9
- 235000019322 gelatine Nutrition 0.000 claims description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 8
- ZEEXVYNJSAWEML-UHFFFAOYSA-N 3-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]prop-2-enoic acid Chemical compound C1=CC(C)=CC=C1SC1=CC=C(C=CC(O)=O)C=C1[N+]([O-])=O ZEEXVYNJSAWEML-UHFFFAOYSA-N 0.000 claims description 7
- 229960001377 benactyzine hydrochloride Drugs 0.000 claims description 7
- 239000007902 hard capsule Substances 0.000 claims description 7
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 5
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 230000002467 anti-pepsin effect Effects 0.000 claims description 4
- 210000004211 gastric acid Anatomy 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 4
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 4
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 230000027119 gastric acid secretion Effects 0.000 claims 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 229960004667 ethyl cellulose Drugs 0.000 claims 2
- -1 hydroxyl-propyl Chemical group 0.000 claims 2
- 239000000463 material Substances 0.000 abstract description 13
- 239000000654 additive Substances 0.000 abstract 1
- 238000005470 impregnation Methods 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 208000018556 stomach disease Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 23
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 206010039509 Scab Diseases 0.000 description 7
- 235000013339 cereals Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 241000209094 Oryza Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 239000011247 coating layer Substances 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000011800 void material Substances 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 2
- 229960000943 tartrazine Drugs 0.000 description 2
- 235000012756 tartrazine Nutrition 0.000 description 2
- 239000004149 tartrazine Substances 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 description 1
- 241000661938 Capsus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 101100070542 Podospora anserina het-s gene Proteins 0.000 description 1
- VVWYOYDLCMFIEM-UHFFFAOYSA-N Propantheline Chemical compound C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 VVWYOYDLCMFIEM-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960000697 propantheline Drugs 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2767374A JPS5512411B2 (forum.php) | 1974-03-12 | 1974-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1054056A true CA1054056A (en) | 1979-05-08 |
Family
ID=12227459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA221,903A Expired CA1054056A (en) | 1974-03-12 | 1975-03-12 | Solid therapeutic preparation remaining in stomach |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3976764A (forum.php) |
| JP (1) | JPS5512411B2 (forum.php) |
| BE (1) | BE826498A (forum.php) |
| CA (1) | CA1054056A (forum.php) |
| CH (1) | CH604719A5 (forum.php) |
| DE (1) | DE2510620C2 (forum.php) |
| DK (1) | DK142802B (forum.php) |
| ES (1) | ES435500A1 (forum.php) |
| FR (1) | FR2263744B1 (forum.php) |
| GB (1) | GB1507521A (forum.php) |
| NL (1) | NL7502952A (forum.php) |
| SE (1) | SE409286B (forum.php) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630257A5 (en) * | 1975-03-17 | 1982-06-15 | Hoffmann La Roche | Sustained release formulation |
| US4167558A (en) * | 1976-02-13 | 1979-09-11 | Hoffmann-La Roche Inc. | Novel sustained release tablet formulations |
| US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
| US4207890A (en) * | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| JPS6024767B2 (ja) * | 1979-08-24 | 1985-06-14 | 塩野義製薬株式会社 | 腸溶性硬カプセル剤 |
| WO1983000284A1 (en) * | 1981-07-15 | 1983-02-03 | Key Pharma | Sustained release theophylline |
| US4451260A (en) * | 1982-03-26 | 1984-05-29 | Minnesota Mining And Manufacturing Company | Sustained release oral medicinal delivery device |
| JPS5953410A (ja) * | 1982-09-20 | 1984-03-28 | Fujisawa Pharmaceut Co Ltd | 新型ソフトカプセル剤 |
| JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
| US4505890A (en) * | 1983-06-30 | 1985-03-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation and method |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| DK62184D0 (da) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
| US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| JPS61107782U (forum.php) * | 1984-12-19 | 1986-07-08 | ||
| US4735804A (en) * | 1985-05-10 | 1988-04-05 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4758436A (en) * | 1985-05-29 | 1988-07-19 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4767627A (en) * | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4666705A (en) * | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4756911A (en) * | 1986-04-16 | 1988-07-12 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4814178A (en) * | 1987-07-01 | 1989-03-21 | Sanford Bolton | Floating sustained release therapeutic compositions |
| DE3803482A1 (de) * | 1988-02-05 | 1989-08-17 | Lohmann Therapie Syst Lts | Schwimmfaehiges orales therapeutisches system |
| JPH082781B2 (ja) * | 1988-10-18 | 1996-01-17 | 嘉明 川島 | 中空顆粒状医薬及びその製法 |
| JPH05507717A (ja) * | 1990-06-25 | 1993-11-04 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | 軟ゼラチンカプセル剤中で使用するための高められた溶解特性を有するアマンタジン塩酸塩懸濁液 |
| US5232704A (en) * | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
| US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| JP2671257B2 (ja) * | 1995-07-13 | 1997-10-29 | エーザイ株式会社 | 溶解遅延性ゼラチン製剤組成物 |
| SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | Astra Ab | New oral formulation |
| IN186245B (forum.php) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| BR9908911A (pt) | 1998-03-19 | 2001-10-02 | Bristol Myers Squibb Co | Sistema bifásico e processo de distribuição por liberação controlada de substâncias farmacêuticas de alta solubilidade |
| EP1245227A1 (en) * | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
| US20030203027A1 (en) * | 2002-04-26 | 2003-10-30 | Ethicon, Inc. | Coating technique for deposition of drug substance on a substrate |
| US20040086566A1 (en) * | 2002-11-04 | 2004-05-06 | Alpharma, Inc. | Waxy matrix dosage forms |
| US7485322B2 (en) * | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
| DE602004016963D1 (en) * | 2003-02-21 | 2008-11-20 | Lek Pharmaceuticals | Therapeutisches system mit amoxicillin und clavulansäure |
| EP1680098A4 (en) * | 2003-11-04 | 2012-06-13 | Supernus Pharmaceuticals Inc | DELAYED RELEASE OF POSITIVELY-LOADED PHARMACOLOGICALLY EFFECTIVE MOLECULES FROM A POLYMER-CONTAINING MATRIX WITH POLARIZED OXYGENATOMES |
| ZA200901162B (en) * | 2006-09-04 | 2010-06-30 | Panacea Biotec Ltd | Programmable buoyant delivery technology |
| WO2010020098A1 (zh) * | 2008-08-18 | 2010-02-25 | 北京天衡药物研究院 | 胃滞留药物释出系统及其制备方法和用途 |
| WO2009087665A2 (en) * | 2007-12-11 | 2009-07-16 | Vishwanath Sudhir Nande | Novel gastroretentive drug delivery system |
| GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
| FR2945945B1 (fr) * | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Procede de preparation de particules creuses et leurs applications |
| FR2945947B1 (fr) | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
| JP5594484B2 (ja) * | 2009-07-06 | 2014-09-24 | 杏林製薬株式会社 | 中空構造を有する錠剤 |
| CN103037850A (zh) | 2010-07-05 | 2013-04-10 | 雅戈泰克股份公司 | 剂型 |
| WO2014014348A1 (en) * | 2012-07-16 | 2014-01-23 | APET Holding B.V. | Gastro-retentive drug delivery system |
| EP2731609A1 (en) * | 2011-07-14 | 2014-05-21 | APeT Holding B.V. | Nicotinamide compositions and the therapeutic use thereof |
| AU2012322323B2 (en) | 2011-10-11 | 2016-04-21 | Sun Pharmaceutical Industries Limited | A gastroretentive dosage system and process of preparation thereof |
| SI2719376T1 (sl) | 2012-10-12 | 2015-06-30 | Omya International Ag | Gastrointestinalna zdravilna formulacija in razdeljevalni sistem in njen naäśin priprave z uporabo funkcionaliziranega kalcijevega karbonata |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| FI3155024T4 (fi) | 2014-06-11 | 2025-07-28 | Massachusetts Institute Of Technology | Residenssirakenteita ja niihin liittyviä menetelmiä |
| EP3034070A1 (en) | 2014-12-18 | 2016-06-22 | Omya International AG | Method for the production of a pharmaceutical delivery system |
| EP3069713A1 (en) | 2015-03-20 | 2016-09-21 | Omya International AG | Dispersible dosage form |
| CN104706613B (zh) * | 2015-03-20 | 2018-01-16 | 华侨大学 | 一种胃漂浮空心缓释片的制备方法 |
| EP3288604B1 (en) | 2015-05-01 | 2021-11-17 | Massachusetts Institute of Technology | Triggerable shape memory induction devices |
| EP3364946A4 (en) | 2015-10-23 | 2019-06-26 | Lyndra, Inc. | STOMACH DISTRIBUTION SYSTEMS FOR DELAYED RELEASE OF THERAPEUTIC ACTIVE SUBSTANCES AND METHOD FOR THEIR USE |
| CN108697649A (zh) | 2015-12-08 | 2018-10-23 | 林德拉有限公司 | 用于胃驻留系统的几何构型 |
| AU2017235598A1 (en) * | 2016-03-18 | 2018-08-09 | Grünenthal GmbH | Floating pharmaceutical dosage form |
| EP3463313A4 (en) | 2016-05-27 | 2019-12-18 | Lyndra, Inc. | MATERIAL ARCHITECTURE FOR STOMACH DWELLING SYSTEMS |
| EP3269361A1 (en) | 2016-07-14 | 2018-01-17 | Omya International AG | Dosage form |
| CN118766834A (zh) | 2016-09-30 | 2024-10-15 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| WO2021176360A1 (en) * | 2020-03-02 | 2021-09-10 | Craft Health Pte Ltd | Oral dosage forms for extended drug release |
| ES2955784T3 (es) * | 2020-10-14 | 2023-12-07 | Hannes Bichsel | Granos biogranulados espumados |
| WO2023166225A1 (en) * | 2022-03-04 | 2023-09-07 | APET Holding B.V. | Digestive enzyme formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3418999A (en) * | 1964-02-12 | 1968-12-31 | Donald W. Davis | Method of swallowing a pill |
| FR1454013A (fr) * | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
| US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
-
1974
- 1974-03-12 JP JP2767374A patent/JPS5512411B2/ja not_active Expired
-
1975
- 1975-03-10 BE BE154189A patent/BE826498A/xx not_active IP Right Cessation
- 1975-03-10 FR FR7507336A patent/FR2263744B1/fr not_active Expired
- 1975-03-11 US US05/557,408 patent/US3976764A/en not_active Expired - Lifetime
- 1975-03-11 DE DE2510620A patent/DE2510620C2/de not_active Expired
- 1975-03-11 SE SE7502725A patent/SE409286B/xx not_active IP Right Cessation
- 1975-03-11 ES ES435500A patent/ES435500A1/es not_active Expired
- 1975-03-11 DK DK97875AA patent/DK142802B/da not_active IP Right Cessation
- 1975-03-12 GB GB10214/75A patent/GB1507521A/en not_active Expired
- 1975-03-12 CH CH315475A patent/CH604719A5/xx not_active IP Right Cessation
- 1975-03-12 CA CA221,903A patent/CA1054056A/en not_active Expired
- 1975-03-12 NL NL7502952A patent/NL7502952A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2263744B1 (forum.php) | 1978-11-24 |
| CH604719A5 (forum.php) | 1978-09-15 |
| FR2263744A1 (forum.php) | 1975-10-10 |
| DE2510620C2 (de) | 1984-01-05 |
| JPS50121418A (forum.php) | 1975-09-23 |
| DK142802B (da) | 1981-02-02 |
| DK142802C (forum.php) | 1981-09-21 |
| ES435500A1 (es) | 1977-02-01 |
| BE826498A (fr) | 1975-06-30 |
| SE7502725L (forum.php) | 1975-09-15 |
| JPS5512411B2 (forum.php) | 1980-04-02 |
| NL7502952A (nl) | 1975-09-16 |
| DE2510620A1 (de) | 1975-09-18 |
| GB1507521A (en) | 1978-04-19 |
| SE409286B (sv) | 1979-08-13 |
| DK97875A (forum.php) | 1975-09-13 |
| US3976764A (en) | 1976-08-24 |
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