CA1041502A - Imidazo (4,5-b) pyridines - Google Patents

Imidazo (4,5-b) pyridines

Info

Publication number
CA1041502A
CA1041502A CA191,585A CA191585A CA1041502A CA 1041502 A CA1041502 A CA 1041502A CA 191585 A CA191585 A CA 191585A CA 1041502 A CA1041502 A CA 1041502A
Authority
CA
Canada
Prior art keywords
group
phenyl
methoxy
pyridine
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA191,585A
Other languages
English (en)
French (fr)
Inventor
Volkard Austel
Eberhard Kutter
Willi Diederen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2305339A external-priority patent/DE2305339C3/de
Priority claimed from DE2361757A external-priority patent/DE2361757A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of CA1041502A publication Critical patent/CA1041502A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA191,585A 1973-02-03 1974-02-01 Imidazo (4,5-b) pyridines Expired CA1041502A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2305339A DE2305339C3 (de) 1973-02-03 1973-02-03 Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
DE2361757A DE2361757A1 (de) 1973-12-12 1973-12-12 Neue imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine

Publications (1)

Publication Number Publication Date
CA1041502A true CA1041502A (en) 1978-10-31

Family

ID=25764640

Family Applications (1)

Application Number Title Priority Date Filing Date
CA191,585A Expired CA1041502A (en) 1973-02-03 1974-02-01 Imidazo (4,5-b) pyridines

Country Status (24)

Country Link
JP (1) JPS5748556B2 (de)
AT (1) AT332873B (de)
BG (1) BG23902A3 (de)
CA (1) CA1041502A (de)
CH (1) CH605939A5 (de)
CS (1) CS200169B2 (de)
DD (1) DD108989A5 (de)
DK (1) DK140760B (de)
ES (1) ES422450A1 (de)
FI (1) FI58126C (de)
FR (1) FR2215968B1 (de)
GB (1) GB1445824A (de)
HK (1) HK4080A (de)
HU (1) HU170909B (de)
IE (1) IE39066B1 (de)
IL (1) IL44127A (de)
NL (1) NL173645C (de)
NO (1) NO139386C (de)
PH (1) PH14988A (de)
PL (1) PL93127B1 (de)
RO (2) RO79057A (de)
SE (1) SE411451B (de)
SU (2) SU563917A3 (de)
YU (2) YU36955B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989498B2 (en) 1999-04-26 2011-08-02 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49109394A (de) * 1973-02-27 1974-10-17
DE3132754A1 (de) * 1981-08-19 1983-03-03 Merck Patent Gmbh, 6100 Darmstadt "2-aryl-imidazo(4,5-b)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung"
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
IL68495A0 (en) * 1982-05-03 1983-07-31 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
US4772600A (en) * 1986-06-09 1988-09-20 A. H. Robins Company, Inc. Fused imidazoheterocyclic compounds and pharmaceutical compositions
JPH01190663A (ja) * 1988-01-22 1989-07-31 Terumo Corp システアミン誘導体及びこれを含有する抗リウマチ剤
WO2011106039A1 (en) 2010-02-24 2011-09-01 Research Triangle Institute Arylpiperazone opioid receptor antagonists
CN103261170B (zh) 2010-12-24 2016-08-24 住友化学株式会社 稠杂环化合物及其用于害虫防治的用途
WO2013191189A1 (ja) * 2012-06-21 2013-12-27 住友化学株式会社 縮合複素環化合物
WO2013191188A1 (ja) 2012-06-22 2013-12-27 住友化学株式会社 縮合複素環化合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989498B2 (en) 1999-04-26 2011-08-02 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme

Also Published As

Publication number Publication date
CH605939A5 (de) 1978-10-13
DK140760C (de) 1980-04-21
DD108989A5 (de) 1974-10-12
PL93127B1 (de) 1977-05-30
IL44127A (en) 1977-05-31
RO84276B (ro) 1984-07-30
RO79057A (ro) 1982-06-25
GB1445824A (en) 1976-08-11
JPS5748556B2 (de) 1982-10-16
PH14988A (en) 1982-03-12
JPS49102693A (de) 1974-09-27
NO139386C (no) 1979-02-28
HK4080A (en) 1980-02-08
NL173645C (nl) 1984-02-16
ES422450A1 (es) 1976-05-01
FI58126B (fi) 1980-08-29
BG23902A3 (en) 1977-11-10
ATA16474A (de) 1976-02-15
FI58126C (fi) 1980-12-10
NL173645B (nl) 1983-09-16
YU36956B (en) 1984-08-31
YU36955B (en) 1984-08-31
SU634673A3 (ru) 1978-11-25
FR2215968A1 (de) 1974-08-30
IE39066L (en) 1974-08-03
AU6512974A (en) 1975-08-07
FR2215968B1 (de) 1977-01-28
YU17674A (en) 1982-06-18
DK140760B (da) 1979-11-12
IL44127A0 (en) 1974-05-16
RO84276A (ro) 1984-05-23
SU563917A3 (ru) 1977-06-30
IE39066B1 (en) 1978-08-02
CS200169B2 (en) 1980-08-29
NO740327L (no) 1974-08-06
NL7401254A (de) 1974-08-06
AT332873B (de) 1976-10-25
NO139386B (no) 1978-11-20
HU170909B (hu) 1977-09-28
SE411451B (sv) 1979-12-27
YU110480A (en) 1982-06-18

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