BRPI9909456A - ácido quinolonecarboxílico ou sais dos mesmos - Google Patents
ácido quinolonecarboxílico ou sais dos mesmosInfo
- Publication number
- BRPI9909456A BRPI9909456A BRPI9909456A BRPI9909456A BRPI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A BR PI9909456 A BRPI9909456 A BR PI9909456A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- optionally substituted
- salts
- alkoxy
- substituted alkyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 241000186427 Cutibacterium acnes Species 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229940055019 propionibacterium acne Drugs 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11014698 | 1998-04-06 | ||
JP34021798 | 1998-11-30 | ||
PCT/JP1999/001799 WO1999051588A1 (fr) | 1998-04-06 | 1999-04-06 | Derives d'acide quinolonecarboxylique ou sels de ceux-ci |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI9909456A true BRPI9909456A (pt) | 2001-10-02 |
BRPI9909456B1 BRPI9909456B1 (pt) | 2013-10-29 |
BRPI9909456B8 BRPI9909456B8 (pt) | 2021-07-06 |
Family
ID=26449822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9909456 BRPI9909456B8 (pt) | 1998-04-06 | 1999-04-06 | Ácido quinolonecarboxílico ou sais dos mesmos |
Country Status (15)
Country | Link |
---|---|
US (1) | US6335447B1 (pt) |
EP (1) | EP1070713B1 (pt) |
JP (1) | JP3346766B2 (pt) |
KR (1) | KR100550078B1 (pt) |
CN (1) | CN1152029C (pt) |
AT (1) | ATE342897T1 (pt) |
BR (1) | BRPI9909456B8 (pt) |
CA (1) | CA2327328C (pt) |
CY (1) | CY1105845T1 (pt) |
DE (1) | DE69933660T2 (pt) |
DK (1) | DK1070713T3 (pt) |
ES (1) | ES2273479T3 (pt) |
HK (1) | HK1039484A1 (pt) |
PT (1) | PT1070713E (pt) |
WO (1) | WO1999051588A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4061194B2 (ja) * | 2001-02-08 | 2008-03-12 | 富山化学工業株式会社 | 6−置換アルキルアミノ−3−ピリジルホウ酸誘導体またはその塩およびそれらの製造法 |
EP1698336A1 (en) * | 2005-03-01 | 2006-09-06 | Ferrer Internacional, S.A. | Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent |
KR101245960B1 (ko) * | 2005-08-01 | 2013-03-21 | 마루호 코 엘티디 | 피리돈카르복시산 유도체를 함유하는 로션제 |
EP2177209A1 (en) | 2008-10-17 | 2010-04-21 | Ferrer Internacional, S.A. | Intravenous solutions and uses |
EP2177214A1 (en) | 2008-10-17 | 2010-04-21 | Ferrer Internacional, S.A. | Solid Oral Dosage Forms and Uses |
EP2177208A1 (en) * | 2008-10-17 | 2010-04-21 | Ferrer Internacional, S.A. | Pharmaceutical topical compositions |
RU2515557C9 (ru) * | 2010-04-06 | 2014-06-27 | Феррер Интернасионал, С.А. | Фармацевтическая соль 8-метил-7-[5-метил-6-(метиламино)-3-пиридинил]-1-циклопропил-4-оксо-1,4-дигидро-3-хинолинкарбоновой кислоты, ее содержащая фармацевтическая композиция, лекарственное средство и способ лечения или профилактики бактериальных инфекций с помощью вышеуказанной соли |
TWI513688B (zh) * | 2010-04-06 | 2015-12-21 | Ferrer Int | 1-環丙基-8-甲基-7-〔5-甲基-6-(甲胺基)-3-吡啶基〕-4-側氧基-1,4-二氫-3-喹啉羧酸鹽 |
EP2621491B1 (en) * | 2010-09-27 | 2018-08-29 | Emergent Product Development Gaithersburg Inc. | 2-pyridone antimicrobial compositions |
HUE036301T2 (hu) * | 2011-08-31 | 2018-06-28 | Otsuka Pharma Co Ltd | Kinolin vegyület |
JP6775869B2 (ja) * | 2015-02-13 | 2020-10-28 | マルホ株式会社 | ピリドンカルボン酸系誘導体を含有する外用剤 |
JP2018528260A (ja) * | 2015-07-28 | 2018-09-27 | ビオーム バイオサイエンシズ プライベート リミティド | 抗菌性治療薬及び予防薬 |
JP7347915B2 (ja) * | 2016-04-28 | 2023-09-20 | マルホ株式会社 | 抗菌剤 |
MX2019005372A (es) | 2016-12-01 | 2019-07-10 | Maruho Kk | Preparacion medica externa para la piel. |
CN107121506B (zh) * | 2017-04-13 | 2019-06-07 | 杭州华东医药集团新药研究院有限公司 | 奥泽沙星杂质及其用途 |
CN108299480A (zh) * | 2017-12-27 | 2018-07-20 | 山东百诺医药股份有限公司 | 一种奥泽沙星及其中间体的制备方法 |
WO2020065668A1 (en) * | 2018-09-26 | 2020-04-02 | Maithri Drugs Pvt Ltd | Crystalline form of ozenoxacin and processes for preparation thereof |
CN111675692A (zh) * | 2020-06-08 | 2020-09-18 | 浙江科技学院 | 一种奥泽沙星的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3441788A1 (de) * | 1984-11-15 | 1986-05-15 | Bayer Ag, 5090 Leverkusen | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US5075319A (en) * | 1987-09-08 | 1991-12-24 | Sterling Drug Inc. | Pyridinyl-quinolone compounds, their preparation and use |
US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
JP3145487B2 (ja) | 1992-06-12 | 2001-03-12 | シスメックス株式会社 | 粒子分析装置 |
DE4301246A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
CA2205406C (en) * | 1994-11-24 | 2008-02-05 | F. Hoffmann-La Roche Ag | Novel benzyl pyrimidines |
CA2242242C (en) * | 1996-02-09 | 2001-08-07 | Toyama Chemical Co., Ltd. | Quinolonecarboxylic acid derivatives or salts thereof |
-
1999
- 1999-04-06 EP EP99912111A patent/EP1070713B1/en not_active Expired - Lifetime
- 1999-04-06 ES ES99912111T patent/ES2273479T3/es not_active Expired - Lifetime
- 1999-04-06 DE DE69933660T patent/DE69933660T2/de not_active Expired - Lifetime
- 1999-04-06 BR BRPI9909456 patent/BRPI9909456B8/pt not_active IP Right Cessation
- 1999-04-06 AT AT99912111T patent/ATE342897T1/de active
- 1999-04-06 WO PCT/JP1999/001799 patent/WO1999051588A1/ja active IP Right Grant
- 1999-04-06 KR KR1020007011078A patent/KR100550078B1/ko not_active IP Right Cessation
- 1999-04-06 CN CNB998059145A patent/CN1152029C/zh not_active Expired - Lifetime
- 1999-04-06 PT PT99912111T patent/PT1070713E/pt unknown
- 1999-04-06 JP JP2000542309A patent/JP3346766B2/ja not_active Expired - Lifetime
- 1999-04-06 DK DK99912111T patent/DK1070713T3/da active
- 1999-04-06 US US09/647,763 patent/US6335447B1/en not_active Expired - Lifetime
- 1999-04-06 CA CA002327328A patent/CA2327328C/en not_active Expired - Lifetime
-
2001
- 2001-12-08 HK HK01108624A patent/HK1039484A1/xx not_active IP Right Cessation
-
2006
- 2006-12-12 CY CY20061101789T patent/CY1105845T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69933660D1 (de) | 2006-11-30 |
CA2327328C (en) | 2007-11-13 |
BRPI9909456B1 (pt) | 2013-10-29 |
EP1070713A1 (en) | 2001-01-24 |
WO1999051588A1 (fr) | 1999-10-14 |
KR20010042463A (ko) | 2001-05-25 |
DE69933660T2 (de) | 2007-08-23 |
PT1070713E (pt) | 2006-12-29 |
CN1152029C (zh) | 2004-06-02 |
ATE342897T1 (de) | 2006-11-15 |
US6335447B1 (en) | 2002-01-01 |
DK1070713T3 (da) | 2006-12-27 |
EP1070713A4 (en) | 2004-09-01 |
CN1299356A (zh) | 2001-06-13 |
ES2273479T3 (es) | 2007-05-01 |
CA2327328A1 (en) | 1999-10-14 |
EP1070713B1 (en) | 2006-10-18 |
BRPI9909456B8 (pt) | 2021-07-06 |
JP3346766B2 (ja) | 2002-11-18 |
KR100550078B1 (ko) | 2006-02-08 |
HK1039484A1 (en) | 2002-04-26 |
CY1105845T1 (el) | 2011-02-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/10/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/04/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 24A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2717 DE 31-01-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |