DE69015239T2 - Chinolinon-Derivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende antibakteriell wirkende Mittel. - Google Patents
Chinolinon-Derivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende antibakteriell wirkende Mittel.Info
- Publication number
- DE69015239T2 DE69015239T2 DE69015239T DE69015239T DE69015239T2 DE 69015239 T2 DE69015239 T2 DE 69015239T2 DE 69015239 T DE69015239 T DE 69015239T DE 69015239 T DE69015239 T DE 69015239T DE 69015239 T2 DE69015239 T2 DE 69015239T2
- Authority
- DE
- Germany
- Prior art keywords
- atom
- derivatives
- hydrogen
- halogen atom
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8232189 | 1989-03-31 | ||
JP23806489 | 1989-09-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69015239D1 DE69015239D1 (de) | 1995-02-02 |
DE69015239T2 true DE69015239T2 (de) | 1995-06-01 |
Family
ID=26423347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69015239T Expired - Fee Related DE69015239T2 (de) | 1989-03-31 | 1990-03-29 | Chinolinon-Derivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende antibakteriell wirkende Mittel. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5245037A (de) |
EP (1) | EP0393400B1 (de) |
KR (1) | KR900014369A (de) |
CN (1) | CN1045971A (de) |
AT (1) | ATE115955T1 (de) |
AU (1) | AU623757B2 (de) |
CA (1) | CA2012681A1 (de) |
DE (1) | DE69015239T2 (de) |
HU (1) | HUT58315A (de) |
IL (1) | IL93938A0 (de) |
PT (1) | PT93599A (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0366189A3 (de) * | 1988-10-24 | 1992-01-02 | Norwich Eaton Pharmaceuticals, Inc. | Antimikrobielle Lactam-Quinolone |
US5407932A (en) * | 1989-03-31 | 1995-04-18 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivatives and antibacterial agents containing the same |
NO179912C (no) * | 1990-11-28 | 1997-01-08 | Daiichi Seiyaku Co | Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat |
US5157128A (en) * | 1990-11-30 | 1992-10-20 | Warner-Lambert Company | Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates |
US5364861A (en) * | 1990-11-30 | 1994-11-15 | Warner-Lambert Company | Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents |
US5258528A (en) * | 1990-11-30 | 1993-11-02 | Warner-Lambert Company | Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group |
CA2095338C (en) * | 1990-11-30 | 2002-04-09 | John Michael Domagala | Individual stereoisomers of 7-¬3-(aminoalkyl)-1-pyrrolidinyl|-quinolonesand naphthyridones as antibacterial agents |
JPH0678335B2 (ja) * | 1991-06-19 | 1994-10-05 | ファイザー・インコーポレーテッド | アザスピロキノロン化合物、その製法および抗菌組成物 |
GB9118183D0 (en) * | 1991-08-23 | 1991-10-09 | Solanki Kishor K | Imaging of infections |
US5412098A (en) * | 1991-12-27 | 1995-05-02 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivative or salt thereof and antibacterial containing the same |
WO1993025545A1 (en) * | 1992-06-09 | 1993-12-23 | Korea Research Institute Of Chemical Technology | Novel quinoline derivatives and processes for preparing the same |
KR0148277B1 (ko) * | 1993-01-18 | 1998-11-02 | 채영복 | 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법 |
DE4301246A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
DE4301247A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride |
WO1994025464A1 (en) * | 1993-04-24 | 1994-11-10 | Korea Research Institute Of Chemical Technology | Novel quinolone carboxylic acid derivatives and process for preparing the same |
TW252107B (de) * | 1993-08-27 | 1995-07-21 | Hokuriku Pharmacetical Co Ltd | |
DE4416622A1 (de) * | 1994-05-11 | 1995-11-16 | Bayer Ag | 8-Amino-10-(azabicycloalkyl)-pyrido[1,2,3-d.e] [1,3,4]benzoxa-diazinderivate |
US5671018A (en) * | 1995-02-07 | 1997-09-23 | Texas Instruments Incorporated | Motion adaptive vertical scaling for interlaced digital image data |
AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
CA2285352A1 (en) * | 1998-01-29 | 1999-08-05 | Suntory Limited | 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase iv inhibitory activity |
KR100364226B1 (ko) * | 1998-03-18 | 2003-01-24 | 주식회사 엘지생명과학 | 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법 |
SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
US7329782B2 (en) | 2001-06-12 | 2008-02-12 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
EP1401829B1 (de) * | 2001-06-15 | 2012-08-22 | Microbiotix, Inc. | Neue heterocyclische antibakterielle verbindungen |
JP2005504807A (ja) | 2001-09-26 | 2005-02-17 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 抗糖尿病薬としての1,8−ナフチリジン誘導体 |
PT1666477E (pt) * | 2003-09-10 | 2013-08-28 | Kyorin Seiyaku Kk | Derivado de 7-(4-substituído-3-ciclopropilaminometil-1- pirrolidinil) quinolonecarboxílico |
AR059035A1 (es) * | 2006-01-16 | 2008-03-12 | Syngenta Participations Ag | Insecticidas derivados de antranilamida |
WO2009022185A2 (en) * | 2007-08-16 | 2009-02-19 | Astrazeneca Ab | 6, 6-fused heterocycles, their pharmaceutical compositions and methos of use |
TWI429643B (zh) * | 2008-02-22 | 2014-03-11 | Actelion Pharmaceuticals Ltd | 唑啶酮衍生物 |
ES2623794T3 (es) * | 2008-12-09 | 2017-07-12 | Gilead Sciences, Inc. | Intermedios para la preparación de moduladores de receptores tipo toll |
CN102443015A (zh) * | 2010-10-13 | 2012-05-09 | 南京明生医药技术有限公司 | 一种7-取代喹啉羧酸衍生物及其制备方法和在抗菌抗结核上的应用 |
AR087072A1 (es) * | 2011-07-08 | 2014-02-12 | Syngenta Participations Ag | Procesos para la preparacion de tietanamina |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
JPS61148179A (ja) * | 1984-12-20 | 1986-07-05 | Dainippon Pharmaceut Co Ltd | 新規ナフチリジン誘導体、そのエステルおよびその塩 |
JPH0633256B2 (ja) * | 1985-12-20 | 1994-05-02 | 大塚製薬株式会社 | キノリンカルボン酸誘導体 |
US4788320A (en) * | 1986-01-20 | 1988-11-29 | Kyorin Pharmaceutical Co., Ltd. | Benzoylacetic acid ester derivatives and process for their preparations |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
EP0259804B1 (de) * | 1986-09-12 | 1993-11-18 | F. Hoffmann-La Roche Ag | Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte |
US4962112A (en) * | 1987-08-04 | 1990-10-09 | Abbott Laboratories | 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds |
US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
-
1990
- 1990-03-21 CA CA002012681A patent/CA2012681A1/en not_active Abandoned
- 1990-03-23 US US07/497,885 patent/US5245037A/en not_active Expired - Fee Related
- 1990-03-28 IL IL93938A patent/IL93938A0/xx unknown
- 1990-03-28 AU AU52281/90A patent/AU623757B2/en not_active Ceased
- 1990-03-29 AT AT90106007T patent/ATE115955T1/de not_active IP Right Cessation
- 1990-03-29 EP EP90106007A patent/EP0393400B1/de not_active Expired - Lifetime
- 1990-03-29 PT PT93599A patent/PT93599A/pt not_active Application Discontinuation
- 1990-03-29 DE DE69015239T patent/DE69015239T2/de not_active Expired - Fee Related
- 1990-03-30 HU HU902023A patent/HUT58315A/hu unknown
- 1990-03-30 KR KR1019900004365A patent/KR900014369A/ko active IP Right Grant
- 1990-03-31 CN CN90101807A patent/CN1045971A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
AU623757B2 (en) | 1992-05-21 |
HUT58315A (en) | 1992-02-28 |
EP0393400B1 (de) | 1994-12-21 |
HU902023D0 (en) | 1990-07-28 |
IL93938A0 (en) | 1990-12-23 |
DE69015239D1 (de) | 1995-02-02 |
CN1045971A (zh) | 1990-10-10 |
AU5228190A (en) | 1990-10-04 |
ATE115955T1 (de) | 1995-01-15 |
EP0393400A1 (de) | 1990-10-24 |
CA2012681A1 (en) | 1990-09-30 |
US5245037A (en) | 1993-09-14 |
KR900014369A (ko) | 1990-10-23 |
PT93599A (pt) | 1990-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |