BRPI1015460A2 - guanetidina para uso no tratamento da hipertensão e sistema de tratamento de hipertensão - Google Patents

guanetidina para uso no tratamento da hipertensão e sistema de tratamento de hipertensão Download PDF

Info

Publication number
BRPI1015460A2
BRPI1015460A2 BRPI1015460-4A BRPI1015460A BRPI1015460A2 BR PI1015460 A2 BRPI1015460 A2 BR PI1015460A2 BR PI1015460 A BRPI1015460 A BR PI1015460A BR PI1015460 A2 BRPI1015460 A2 BR PI1015460A2
Authority
BR
Brazil
Prior art keywords
hypertension
guanetidine
renal
agents
further characterized
Prior art date
Application number
BRPI1015460-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Kirk Patrick Seward
Original Assignee
Mercator Medsystems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercator Medsystems, Inc. filed Critical Mercator Medsystems, Inc.
Publication of BRPI1015460A2 publication Critical patent/BRPI1015460A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1002—Balloon catheters characterised by balloon shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • A61M2025/009—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip the needle having a bent tip, i.e. the needle distal tip is angled in relation to the longitudinal axis of the catheter

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1015460-4A 2009-04-22 2010-04-22 guanetidina para uso no tratamento da hipertensão e sistema de tratamento de hipertensão BRPI1015460A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17170209P 2009-04-22 2009-04-22
US61/171,702 2009-04-22
US18670409P 2009-06-12 2009-06-12
US61/186,704 2009-06-12
PCT/US2010/032097 WO2010124120A1 (en) 2009-04-22 2010-04-22 Use of guanethidine for treating hypertension by local vascular delivery

Publications (1)

Publication Number Publication Date
BRPI1015460A2 true BRPI1015460A2 (pt) 2020-08-18

Family

ID=43011483

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015460-4A BRPI1015460A2 (pt) 2009-04-22 2010-04-22 guanetidina para uso no tratamento da hipertensão e sistema de tratamento de hipertensão

Country Status (11)

Country Link
US (8) US8399443B2 (enExample)
EP (2) EP3158866A3 (enExample)
JP (2) JP5800801B2 (enExample)
KR (1) KR101764439B1 (enExample)
CN (2) CN102573466A (enExample)
AU (2) AU2010238744B2 (enExample)
BR (1) BRPI1015460A2 (enExample)
CA (1) CA2759929C (enExample)
NZ (3) NZ710157A (enExample)
RU (1) RU2011142447A (enExample)
WO (1) WO2010124120A1 (enExample)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
EP1667595B1 (en) * 2003-09-12 2014-01-01 Vessix Vascular, Inc. System for selectable eccentric remodeling and/or ablation of atherosclerotic material
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US7742795B2 (en) 2005-03-28 2010-06-22 Minnow Medical, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
CN101076290B (zh) 2004-12-09 2011-11-23 铸造品股份有限公司 主动脉瓣修复
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
WO2007136566A2 (en) 2006-05-19 2007-11-29 Prorhythm, Inc. Ablation device with optimized input power profile and method of using the same
CA2666660C (en) 2006-10-18 2015-06-02 Minnow Medical, Inc. Inducing desirable temperature effects on body tissue
WO2008049084A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
ES2407329T3 (es) 2006-10-18 2013-06-12 Vessix Vascular, Inc. Sistema para inducir efectos de temperatura deseables sobre un tejido corporal
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US8470337B2 (en) * 2008-03-13 2013-06-25 Allergan, Inc. Therapeutic treatments using botulinum neurotoxin
US9089700B2 (en) 2008-08-11 2015-07-28 Cibiem, Inc. Systems and methods for treating dyspnea, including via electrical afferent signal blocking
US20100057048A1 (en) 2008-09-04 2010-03-04 Stephen Eldredge Apparatus, System, and Method for Treating Atypical Headaches
JP5307900B2 (ja) 2008-11-17 2013-10-02 べシックス・バスキュラー・インコーポレイテッド 組織トポグラフィの知識によらないエネルギーの選択的な蓄積
WO2010096134A1 (en) 2008-12-04 2010-08-26 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
EP2376011B1 (en) 2009-01-09 2019-07-03 ReCor Medical, Inc. Apparatus for treatment of mitral valve insufficiency
NZ710157A (en) * 2009-04-22 2016-08-26 Mercator Medsystems Inc Use of guanethidine for treating hypertension by local vascular delivery
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
AU2010313379B2 (en) 2009-10-30 2015-11-05 Recor Medical, Inc. Method and apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
US8975233B2 (en) 2010-01-26 2015-03-10 Northwind Medical, Inc. Methods for renal denervation
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
US20130138082A1 (en) * 2010-03-24 2013-05-30 Amr Salahieh Intravascular Tissue Disruption
KR20130108067A (ko) 2010-04-09 2013-10-02 베식스 바스큘라 인코포레이티드 조직 치료를 위한 발전 및 제어 장치
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
WO2012052920A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Therapeutics reservoir
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
DK2658605T3 (en) * 2010-12-28 2016-11-14 Cibiem Inc CATH for endovascular ablation of glomus CAROTICUM FOR RESTORING sympathetic BALANCE WITH PATIENT
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
WO2012161875A1 (en) 2011-04-08 2012-11-29 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
CA2834040C (en) * 2011-04-28 2020-01-14 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
US12446942B2 (en) 2011-07-12 2025-10-21 Verve Medical, Inc. Treatment of kidney disease using renal nerve denervation via the renal pelvis
US20250177025A9 (en) 2011-07-12 2025-06-05 Verve Medical, Inc. Treatment of Kidney Disease Using Renal Nerve Denervation Via the Renal Pelvis
JP2014525781A (ja) 2011-07-12 2014-10-02 ベルブ メディカル， インコーポレイテッド 腎盂を通した腎神経の脱神経
US12279800B2 (en) 2011-07-12 2025-04-22 Verve Medical, Inc. Methods and devices for treating polycystic kidney disease and its symptoms
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
CN103813829B (zh) 2011-07-22 2016-05-18 波士顿科学西美德公司 具有可定位于螺旋引导件中的神经调制元件的神经调制系统
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US20140343590A1 (en) 2011-09-16 2014-11-20 Syntach Ag Device, And A Method For Treatment Of Increased Blood Pressure
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
WO2013059202A1 (en) 2011-10-18 2013-04-25 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US9162046B2 (en) 2011-10-18 2015-10-20 Boston Scientific Scimed, Inc. Deflectable medical devices
US10849879B2 (en) * 2011-10-19 2020-12-01 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
JP2014532654A (ja) * 2011-10-26 2014-12-08 シュタイン, エミリー, エイ.STEIN, Emily, A. 神経機能に影響を及ぼす薬剤、方法、およびデバイス
CN104023662B (zh) 2011-11-08 2018-02-09 波士顿科学西美德公司 孔部肾神经消融
WO2013074813A1 (en) 2011-11-15 2013-05-23 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
CA2859989C (en) 2011-12-23 2020-03-24 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US20150111918A1 (en) 2012-03-08 2015-04-23 Medtronic Ardian Luxembourg S.a.r.l Immune system neuromodulation and associated systems and methods
WO2013134667A1 (en) 2012-03-09 2013-09-12 Mayo Foundation For Medical Education And Research Modulating afferent signals to treat medical conditions
US9393291B2 (en) 2012-04-12 2016-07-19 Botulinum Toxin Research Associates, Inc. Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
EP2840993A4 (en) 2012-04-24 2016-03-30 Cibiem Inc ENDOVASCULAR CATHETERS AND METHOD FOR CAROTID BODY ABLATION
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
EP2854680A4 (en) 2012-06-01 2016-07-20 Cibiem Inc METHODS AND DEVICES FOR ABLATION OF CRYOGENIC CAROTID BODY
EP2854681A4 (en) 2012-06-01 2016-02-17 Cibiem Inc PERCUTANEOUS METHODS AND DEVICES FOR CAROTIDE BODY ABLATION
US8951296B2 (en) * 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
WO2014005155A1 (en) 2012-06-30 2014-01-03 Cibiem, Inc. Carotid body ablation via directed energy
US20140018788A1 (en) * 2012-07-04 2014-01-16 Zoar Jacob ENGELMAN Devices and Systems for Carotid Body Ablation
CN104540465A (zh) 2012-08-24 2015-04-22 波士顿科学西美德公司 带有含单独微孔隙区域的球囊的血管内导管
EP2895095A2 (en) 2012-09-17 2015-07-22 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US8740849B1 (en) 2012-10-29 2014-06-03 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
EP4230162B1 (en) * 2012-11-02 2024-10-09 Neurotronic, Inc. Chemical ablation formulations for various diseases
US10537375B2 (en) 2015-04-24 2020-01-21 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US12208224B2 (en) 2012-11-02 2025-01-28 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US9409000B2 (en) * 2012-12-10 2016-08-09 Abbott Cardiovascular Systems Inc. Balloon with fibers for treatment of blood vessels
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
CN106178294B (zh) 2013-03-14 2018-11-20 瑞蔻医药有限公司 一种血管内的基于超声波的消融系统
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
WO2014150553A1 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US20140288015A1 (en) * 2013-03-15 2014-09-25 Kondapavulur T. VENKATESWARA-RAO Methods and devices for affecting nerve function
WO2014205399A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9833283B2 (en) 2013-07-01 2017-12-05 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
WO2015006573A1 (en) 2013-07-11 2015-01-15 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
EP3019105B1 (en) 2013-07-11 2017-09-13 Boston Scientific Scimed, Inc. Devices for nerve modulation
US9925001B2 (en) 2013-07-19 2018-03-27 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
US10342609B2 (en) 2013-07-22 2019-07-09 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3024405A1 (en) 2013-07-22 2016-06-01 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015027096A1 (en) 2013-08-22 2015-02-26 Boston Scientific Scimed, Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
EP3041425B1 (en) 2013-09-04 2022-04-13 Boston Scientific Scimed, Inc. Radio frequency (rf) balloon catheter having flushing and cooling capability
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
WO2015057521A1 (en) 2013-10-14 2015-04-23 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
AU2014334574B2 (en) 2013-10-15 2017-07-06 Boston Scientific Scimed, Inc. Medical device balloon
WO2015057961A1 (en) 2013-10-18 2015-04-23 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires and related methods of use and manufacture
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US10286190B2 (en) 2013-12-11 2019-05-14 Cook Medical Technologies Llc Balloon catheter with dynamic vessel engaging member
CN105899157B (zh) 2014-01-06 2019-08-09 波士顿科学国际有限公司 抗撕裂柔性电路组件
EP3102136B1 (en) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
CN106572875A (zh) 2014-02-07 2017-04-19 沃夫医药公司 用于肾盂消融的方法和系统
US20240099988A1 (en) 2014-02-07 2024-03-28 Verve Medical, Inc. Treatment of Kidney Disease by Renal Pelvis Ablation
US9855402B2 (en) 2014-02-15 2018-01-02 Rex Medical, L.P. Apparatus for delivering fluid to treat renal hypertension
EP3116408B1 (en) 2014-03-12 2018-12-19 Cibiem, Inc. Ultrasound ablation catheter
US20170065327A1 (en) * 2014-04-01 2017-03-09 Mayo Foundation For Medical Education And Research Methods and materials for treating elevated sympathetic nerve activity conditions
US20160220789A1 (en) * 2014-04-11 2016-08-04 Stephen Eldredge Devices, systems, and methods for spg block and neuro-modulation
US20150290439A1 (en) * 2014-04-14 2015-10-15 Stephen Eldredge Methods for bilateral central autonomic neuromodulation
EP3132822B1 (en) * 2014-04-14 2018-10-31 Toppan Printing Co., Ltd. Injection device
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US20160045257A1 (en) * 2014-08-14 2016-02-18 Ablative Solutions, Inc. Method for selection and treatment of hypertensive patients with renal denervation
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
EP3212274A4 (en) 2014-10-30 2018-06-27 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
EP3226795B1 (en) 2014-12-03 2020-08-26 Metavention, Inc. Systems for modulating nerves or other tissue
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
EP3069719B1 (de) * 2015-03-19 2019-10-09 B. Braun Melsungen AG Renale denervierung
EP3288626B8 (en) 2015-04-27 2025-12-10 Tulavi Therapeutics, Inc. Substances and compositions for use in blocking nerve regeneration
US10207110B1 (en) 2015-10-13 2019-02-19 Axon Therapies, Inc. Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CA3031761A1 (en) 2016-06-29 2018-01-04 Tulavi Therapeutics, Inc. Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
CN109843160B (zh) 2016-07-29 2022-04-15 阿克松疗法公司 通过脏神经消融术治疗心脏衰竭的装置、系统和方法
KR102039608B1 (ko) 2017-11-03 2019-11-01 주식회사 셀버틱스 미도드린을 포함하는 조성물 및 이의 용도
WO2019118976A1 (en) 2017-12-17 2019-06-20 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
EP4406567A3 (en) 2018-01-26 2024-10-09 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
WO2019178231A1 (en) * 2018-03-14 2019-09-19 Mercator Medsystems, Inc. Medical instrument and medical method for localized drug delivery
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN112638437B (zh) 2018-07-02 2023-12-08 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
WO2020257763A1 (en) 2019-06-20 2020-12-24 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
CN121177644A (zh) * 2019-06-25 2025-12-23 纽敦力公司 递送导管和疾病治疗方法
US11497552B2 (en) 2019-07-09 2022-11-15 Juad, Inc. Apparatus, systems and methods for transvascular access to the brain
WO2021146724A1 (en) 2020-01-17 2021-07-22 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
CA3267324A1 (en) 2022-09-19 2024-03-28 M2Sp Llc TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION WITH GUANETHIDINE AND GUANADREL
DE202023104190U1 (de) 2023-07-26 2023-09-13 Haritha Lakshmi Jandhyam Vorrichtung zur Entwicklung eines natürlichen therapeutischen Mittels zur Behandlung von hypertensiven Schwangerschaftsbeschwerden

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271448A (en) 1961-11-21 1966-09-06 Pfizer & Co C Phenoxyalkyl aminoguanidines
US3301755A (en) 1962-04-18 1967-01-31 Ciba Geigy Corp Allylic guanidines
US3723463A (en) 1970-03-09 1973-03-27 Squibb & Sons Inc Dibenzooxazepines and dibenzothiazepines
US3780733A (en) * 1972-07-24 1973-12-25 Manzor M Martinez Catheter
US4105030A (en) * 1977-01-03 1978-08-08 Syntex (U.S.A.) Inc. Implant apparatus
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4496573A (en) 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
HU212760B (en) * 1989-06-20 1997-02-28 Denes Method and device for the apportion of chemical materials into the vein wall
US5242397A (en) * 1989-06-20 1993-09-07 Cedars-Sinai Medical Center Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
US5196024A (en) * 1990-07-03 1993-03-23 Cedars-Sinai Medical Center Balloon catheter with cutting edge
US5320634A (en) 1990-07-03 1994-06-14 Interventional Technologies, Inc. Balloon catheter with seated cutting edges
US5147294A (en) * 1990-10-01 1992-09-15 Trustees Of Boston University Therapeutic method for reducing chronic pain in a living subject
WO1993020784A1 (en) * 1992-04-10 1993-10-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5538504A (en) * 1992-07-14 1996-07-23 Scimed Life Systems, Inc. Intra-extravascular drug delivery catheter and method
DE4235506A1 (de) * 1992-10-21 1994-04-28 Bavaria Med Tech Katheter zur Injektion von Arzneimitteln
US5540664A (en) * 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US6009875A (en) 1993-10-14 2000-01-04 Berlex Laboratories, Inc. Use of sympathetic antagonists for treatment of chronic muscle pain
US6787569B1 (en) 1994-02-03 2004-09-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US5423851A (en) * 1994-03-06 1995-06-13 Samuels; Shaun L. W. Method and apparatus for affixing an endoluminal device to the walls of tubular structures within the body
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6009877A (en) * 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US5645564A (en) * 1995-05-22 1997-07-08 Regents Of The University Of California Microfabricated therapeutic actuator mechanisms
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5722989A (en) * 1995-05-22 1998-03-03 The Regents Of The University Of California Microminiaturized minimally invasive intravascular micro-mechanical systems powered and controlled via fiber-optic cable
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5693029A (en) * 1995-07-10 1997-12-02 World Medical Manufacturing Corporation Pro-cell intra-cavity therapeutic agent delivery device
US5746716A (en) * 1995-07-10 1998-05-05 Interventional Technologies Inc. Catheter for injecting fluid medication into an arterial wall
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5851197A (en) * 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
US6093172A (en) * 1997-02-05 2000-07-25 Minimed Inc. Injector for a subcutaneous insertion set
US5911737A (en) * 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US20040067197A1 (en) * 1997-11-26 2004-04-08 Guy Leclerc Radiolabeled DNA carrier, method of preparation and therapeutic uses thereof
CA2312919C (en) * 1997-12-31 2004-12-14 Minimed, Inc. Insertion device for an insertion set and method of using the same
US6059766A (en) * 1998-02-27 2000-05-09 Micro Therapeutics, Inc. Gynecologic embolotherapy methods
JPH11262527A (ja) 1998-03-17 1999-09-28 Buaayu:Kk 血管内擦過バルーンカテーテル
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6210392B1 (en) * 1999-01-15 2001-04-03 Interventional Technologies, Inc. Method for treating a wall of a blood vessel
US6302870B1 (en) * 1999-04-29 2001-10-16 Precision Vascular Systems, Inc. Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6283947B1 (en) * 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6494862B1 (en) * 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
DE60018797T2 (de) 1999-12-16 2006-04-13 Dermatrends, Inc., San Diego Hydroxide freisetzende verbindungen zum verbessern der hautdurchlässigkeit
WO2001087768A2 (en) * 2000-05-15 2001-11-22 Tecan Trading Ag Use of vapor-deposited conformal coatings in microfluidic structures
US7074834B2 (en) 2000-05-24 2006-07-11 University Of Kentucky Foundation Long acting, reversible veterinary sedative and analgesic and method of use
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US6602241B2 (en) * 2001-01-17 2003-08-05 Transvascular, Inc. Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
US7127284B2 (en) 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
JP3612581B2 (ja) 2001-06-18 2005-01-19 哲 吉田 血管等用のバルーン型薬液注射器
US6547803B2 (en) * 2001-09-20 2003-04-15 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
US7547294B2 (en) 2001-09-20 2009-06-16 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
US6860867B2 (en) 2001-09-20 2005-03-01 The Regents Of The University Of California Method of interventional surgery
US7247149B2 (en) * 2001-12-20 2007-07-24 Advanced Cardiovascular Systems, Inc. Contact and penetration depth sensor for a needle assembly
US20060189941A1 (en) * 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US7744584B2 (en) * 2002-01-22 2010-06-29 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US20030171734A1 (en) * 2002-01-22 2003-09-11 Endobionics, Inc. Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
US7162303B2 (en) * 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8551069B2 (en) * 2002-04-08 2013-10-08 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for treating contrast nephropathy
US8150519B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US6978174B2 (en) * 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7756583B2 (en) * 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7141041B2 (en) * 2003-03-19 2006-11-28 Mercator Medsystems, Inc. Catheters having laterally deployable needles
US20040213770A1 (en) * 2003-04-22 2004-10-28 Endobionics, Inc. Methods and systems for treating ischemic cardiac and other tissues
US7149574B2 (en) * 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7022214B2 (en) 2004-01-21 2006-04-04 Bio-Rad Laboratories, Inc. Carrier ampholytes of high pH range
US20070269385A1 (en) * 2006-05-18 2007-11-22 Mercator Medsystems, Inc Devices, methods, and systems for delivering therapeutic agents for the treatment of sinusitis, rhinitis, and other disorders
US20080004596A1 (en) * 2006-05-25 2008-01-03 Palo Alto Institute Delivery of agents by microneedle catheter
CN105056408B (zh) * 2006-06-28 2018-09-25 美敦力Af卢森堡公司 用于热诱导的肾神经调制的系统
US7691080B2 (en) * 2006-09-21 2010-04-06 Mercator Medsystems, Inc. Dual modulus balloon for interventional procedures
JP5212373B2 (ja) * 2007-09-12 2013-06-19 ソニー株式会社 画像処理装置及び画像処理方法
US8470337B2 (en) * 2008-03-13 2013-06-25 Allergan, Inc. Therapeutic treatments using botulinum neurotoxin
NZ710157A (en) * 2009-04-22 2016-08-26 Mercator Medsystems Inc Use of guanethidine for treating hypertension by local vascular delivery
CA2834040C (en) * 2011-04-28 2020-01-14 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
US10849879B2 (en) * 2011-10-19 2020-12-01 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation

Also Published As

Publication number Publication date
US8399443B2 (en) 2013-03-19
EP2421364A4 (en) 2012-10-17
US11083877B2 (en) 2021-08-10
US20200094028A1 (en) 2020-03-26
US20130204131A1 (en) 2013-08-08
NZ619320A (en) 2015-08-28
KR20120011049A (ko) 2012-02-06
AU2016200979B2 (en) 2017-06-08
EP3158866A2 (en) 2017-04-26
RU2011142447A (ru) 2013-05-27
US20150224289A1 (en) 2015-08-13
US20250058091A1 (en) 2025-02-20
US20110104061A1 (en) 2011-05-05
JP2012524808A (ja) 2012-10-18
US20210330944A1 (en) 2021-10-28
AU2010238744B2 (en) 2015-11-26
AU2010238744A1 (en) 2011-11-17
US20110104060A1 (en) 2011-05-05
JP5800801B2 (ja) 2015-10-28
JP5984884B2 (ja) 2016-09-06
CA2759929A1 (en) 2010-10-28
CN104825445A (zh) 2015-08-12
CA2759929C (en) 2017-03-21
US20130287698A1 (en) 2013-10-31
CN102573466A (zh) 2012-07-11
US9011879B2 (en) 2015-04-21
EP3158866A3 (en) 2017-07-26
NZ710157A (en) 2016-08-26
WO2010124120A1 (en) 2010-10-28
EP2421364A1 (en) 2012-02-29
US8465752B2 (en) 2013-06-18
NZ596041A (en) 2014-02-28
JP2014221833A (ja) 2014-11-27
KR101764439B1 (ko) 2017-08-02
US9199065B2 (en) 2015-12-01
AU2016200979A1 (en) 2016-03-10

Similar Documents

Publication Publication Date Title
US20250058091A1 (en) Treatment of hypertension by renal vascular delivery of guanethidine
JP6069336B2 (ja) 腎の脱神経を包含する治療効果を増強するための組織および細胞の局所的調節
US8975233B2 (en) Methods for renal denervation
US20060282120A1 (en) Neurotoxic agents and devices to treat atrial fibrillation
JP2016519088A (ja) 神経機能に作用する方法および装置
Baek et al. Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles
HK1173337A (en) Use of guanethidine for treating hypertension by local vascular delivery

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A01N 37/52 , A61K 31/155

Ipc: A61K 31/155 (2006.01), A61K 31/395 (2006.01), A61K

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL