US3780733A - Catheter - Google Patents

Catheter Download PDF

Info

Publication number
US3780733A
US3780733A US3780733DA US3780733A US 3780733 A US3780733 A US 3780733A US 3780733D A US3780733D A US 3780733DA US 3780733 A US3780733 A US 3780733A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
needle
end
stylet
catheter
tubular length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Manzor M Martinez
Original Assignee
Manzor M Martinez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069Tip not integral with tube

Abstract

For use in administering continual spinal anesthesia, a catheter for longitudinal movement within the lumen of a relatively large needle used to approach just about to the spinal column to the end of the catheter, a thin needle with a through opening is secured and a stylet is provided in the catheter to advance the small needle relative to the large needle to pierce the wall of the spinal column in a relatively fine opening through which the anesthesia is administered.

Description

United States Patent Martinez-Manzor Dec. 25, 1973 CATHETER 3,358,684 12/1967 Marshall l28/2l4.4

3,506,007 4 I970 H k' Inventor: Manuel Marlinel'Manm" 9755 3,380,448 4i1968 et al. l28/215 S.W. 304th St., Homestead, Fla.

Primary Exammer-Dalton L. Truluck [22] Filed: July 24, 19 Attorney.lohn Cyril Malloy [21] Appl. No.: 274,438

[57] ABSTRACT [52] Cl 128/215 128/221 128/347 For use in administering continual spinal anesthesia, a A61m Catheter for longitudinal movement within the lumen N! d 0 Search of a relatively large needle used to pp h j 128/214 348 about to the spinal column to the end of the catheter,

a thin needle with a through opening is secured and a v [56] References C'ted stylet is provided in the catheter to advance the small UNITED STATES PATENTS needle relative to the large needle to pierce the wall of 3,584,624 6/1971 DeCiutiis 128/2144 the spinal column in a relatively fine opening through 2.828.744 4/1958 Hirsch et al. which the anesthesia is administered. 2.512.569 6/1950 Saffir 3,l8l,336 5/l965 Schofield 128 221 x 5 Claims, 4 Drawing Figures CATHETER FIELD OF THE INVENTION This invention relates to continuous spinal anesthesia; and, more particularly, this invention relates to an improved needle carrying catheter for use in piercing the spinal column wall and through which anesthesia is to be introduced as required into the column of the spine through a relatively small opening.

BACKGROUND OF THE INVENTION In the past, it has been learned and subsequently widely recognized that there are advantages to continual spinal anesthesia in that the response to the introduction of anesthesia directly into the spinal column can produce more precise results and control. Albeit recognized however, as a practical matter, actual application of the procedure has been limited because it has heretofore been difficult to pass a needle through the back ofa patient to the exact depth required for the procedure and to introduce the anesthesia through an opening small enough so that there are not attendant side effects which are very undesirable, as is explained more fully hereinafter.

OBJECTS OF THIS INVENTION It is an object of this invention to provide an improved catheter which carries on its end a small needle and means to advance it relative to a larger needle, after the tip of the larger needle has been prepositioned near the spinal column, so that on being advanced, the small needle will pierce the spinal column wall in a fine opening sufficient for introducing anesthesia but not so large as to cause injury to the spinal wall and attendant difficulties described herein.

In accordance with this general object and purpose, the instant invention will now be described with reference to the accompanying drawings in which:

DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of the improved catheter;

FIG. 2 is a diagrammatic view of the first step in the process of introducing a large needle into the spine area;

FIG. 3 is a view in cross section-illustrating the use of the catheter of FIG. 1 and details of its construction; and

FIG. 4 is a view of the spinal area in cross section illustrated in the affected area of the operation in which the improved catheter is employed.

DETAILED DESCRIPTION OF THE INVENTION Continuous spinal anesthesia is a recognized, accepted and highly effective technique. This invention relates to an improved catheter for use in administering continuous spinal anesthesia. Generally, to perform the task, the anesthesic solution is introduced directly into the dura mater 8 and arachnoid using the improved catheter, to be described, which carries a relatively small needle 19 to pierce the dura wall 21. The wall is pierced by the smaller needle after the extradural space 10 has been reached by a larger needle 12 by advancing the smaller needle carried by the catheter. This is done in the following manner.

First, an appropriate interspinous vertebral space is selected; the surrounding skin is scrubbed with an antiseptic solution and dried-completely;.and anesthesiaof the skin and soft tissues performed. The extradural space 10 is reached with a straight relatively large needle 12, preferably about 15 gauge, with a stylet in place. To the extent possible the bevel 13 of the needle is presented in longitudinal position, for an easier pass through the skin and supra-spinous and interspinous ligaments 14. When the characteristic major resistance of the flavum ligament 15, between the extra dura l0 and the zone 14 is perceived, the stylet, not shown, is removed and the distal end of the big needle is connected to a specially treated, very sensitive, small, 2 cc. syringe of glass filled with air, not shown.

The extradural space 10 on the proximal side of the flavum ligament 15 is reached in the following manner. The needle 12 is very gently advanced or introduced while with the other hand an effort is made to force the penetration of the air in the syringe through the needle. The introduction of air will be unsuccessful until there occurs the penetration of the needle through the favum ligament 15 and penetration begins into the extradural space 10. This will be recognized because, when the extradural space is reached, there will be a sudden lack of resistance which is characteristic of this area contrasting to the resistance offered by the flavum ligament. The lack of resistance confirms that the extradural space has been reached. It is also confirmed because, when the extradural space is reached, the air of the syringe is introduced easily and rapidly and, simultaneously, there occurs a sudden inversion of the resistance against removal of the big needle. This is sometimes referred to as the double inverted resistance sign; in other words, the resistance given by the flavum ligament 15 is overcome and the negative pressure which characterizes the penetration to the extradural space is sensed.

As shown in FIG. 2, once the extradural space-10 is reached by the tip of the 12, the improved catheter 17, shownin FIG. 1 and to be described hereinafter, is introduced through the lumen 18 of the needle 12, with a stylet 16, see FIG. 3, in place in the catheter 17. A firm and quick pressure is then applied to' the catheter 17 by means of the stylet 16 which will cause a small needle 19 on the end of the catheter to penetrate the dura wall 21 and enter the dura mater 8 and arachnoid, reaching the subarachnoid space. Thereafter, the stylet 16 is removed. Then, a syringe is connected to the distal end of the needle carrying catheter and a gentle suction is made until the CEF, or spinal fluid, is obtained, confirming the location of the tip of the small needle. The anesthetic solution, which is ready in another syringe, may then be introduced directly into the dura through the catheter in intermittent injections of the anesthetic solution any time it will be needed during the surgical procedure.

It will be helpful to refer to FIG. 3 at this juncture in summary of the procedure. The extradural space 10 between the flavum ligament 15 and the dura wall 21 is reached by a relatively big needle 12; and the location of the tip or bevel 13 of the big needle is sensed in the manner described above. The catheter 17 is inserted through the column 18 of the needle 12 and the wall 21 of the dura is penetrated by a small needle 19 fixed on the tip 20 of the catheter. A preferred embodiment of the small needle carrying catheter will now be-more FIG. 1.

The catheter 17 is composed of a plastic catheter tube 31 of suitable length, which may be similar to a urethral catheter in consistence and calibration and of about 20 gauge. To the tip 20 of the catheter tube 31', a thin needle 19 of about 25 gauge is secured with the needle extending beyond the tube end about 0.5 centimeter, which corresponds for the purposes described above to the extradural and dura space cross sectional dimension and with the catheter and needle being sized so as to be able to pass through the column of the big needle, which is preferably gauge.

Means are provided to secure the smaller needle 19 to the tube; in the embodiment shown the means are as follows. In the plastic wall 31 at the tip of the catheter the surface of the proximal end 33 of the needle 19 is provided with a key surface or pattern in relief 33 to join it to the tube, i.e., the needle is embedded in the tube wall. It will be seen that the lumen 37 of the needle is characterized by converging side walls 39 to the distal end 41, which has an opening or mouth 43.

In use, through the center or column 45 of the catheter 17 the stylet 16 is passed; it has a terminal end of a dimension greater than the mouth 43 of the needle, but less than the inside diamter of the catheter tube, so that, when a longitudinally directed force is applied to the stylet, its leading edge will bear against the inside wall 37 of the needle for use in driving the relatively small needle 19 through the dura wall and into the dura mater.

It is thus seen that the above described needle carrying catheter provides a means for introducing anesthetic solution into the dura through a small opening relative to that which'would be made if the big needle were advance through the dura wall, which heretofore, when done has been attendant with great disadvantage because of an increase in the rate of postanesthesia sequalae from the relatively large perforation of the dura wall, dura mater and arachnoid. Because of the relatively large perforation caused by a large needle, in the past, direct introduction of anesthesic solution directly into the dura has been limited to a relatively small number of patients denying to others the recognized benefits of continuous spinal anesthesia introduced directly into the dura which has been widely recognized tohave special advantages but for the injury to the dura wall, etc., as explained above. In summary, this invention provides a catheter for subarachnoid anesthesia adopted for wide application in surgery. it will be seen that the catheter comprises a tubular length of plastic material of a diameter small enough to be passed through a larger needle of appropriate size for passage through the skin and supraspinous and interspinous ligaments, including the flavum ligament, which catheter has fixed to its leading end a thin needle which is used to extend through the mouth of the larger needle and is used to pierce the dura wall in a small perforation when advanced using a stylet, or introducer, sized for longitudinal movement of advance through the catheter to bear against the inside wall of the relatively small needle to advance it and the catheter and penetrate the dura wall, which stylet can then be removed for the introduction of anesthetic solution directly into the dura or subarachnoid space through the column of the catheter. In the preferred embodiment means are provided on the inner end 51 of the stylet 16 to coact with the wall of the needle. The means of the embodiment shown are simply the inner end of the stylet being sized so as not to pass through the opening of the small needle but rather to bear against the walls which converge to the tip to apply an advancement force. Other types of mutually intercooperating means may optionally be provided to interconnect the stylet and the catheter. Also, the outer end 61 of the catheter stylet may be provided with means 63 to aid in advancing the catheter, the preferred embodiment including a plastic body 65 having an enlarged outer end and a somewhat smaller end in which the outer end of the stylet is captivated by suitable means.

What is claimed is:

l. A spinal anethesia administering apparatus comprising in combination, a first big needle defining a lumen and a catheter sized for longitudinal movement removable received in the lumen of said big needle, said catheter including, a tubular length having a first end zone and a second end zone and of a diameter smaller than the lumen of the big needle,

a thin needle portion on the first end zone of said tubular length having a through passageway and a distal end portion having a tissue wall piercing tip and a proximal end portion and with said through passageway being in fluid transmitting engagement with said tubular length,

an elongated stylet having a first end and a second end and with said first end in said tubular length and with said second end being exterior of said tubular length, and said stylet being of a length greater than said tubular length and being sized for longitudinal coaxial movement in the tubular length and being sized less than said through opening in said thin needle portion, and mutually interco-operating means on the first end of the stylet and said thin needle for applying a longitudinal force to advance the thin needle and tubular length relative to the big needle after said big needle has been utilized to penetrate to a predetermined depth for a second stage of penetration by said thin needle, whereupon the stylet may be removed from said combination and material be injected through said tubular length and thin needle.

2. The combination as set forth in claim 1 wherein the interco-operating means on the first end of the stylet and said thin needle comprise walls included in said thin needle converging to a constricted opening at the distal end, said opening being of a diameter greater than the diameter of the first end of said stylet and the diameter of said stylet being less than the span between the walls of said thin needle at its proximal end to bear against the wall of the needle for advancing movement of the catheter relative to the big needle when longitudinal force is applied to the stylet.

3. The catheter as set forth in claim 1 wherein the catheter is of about 20 gauge size, the thin needle is of about 25 gauge size and the longitudinal dimension of the small needle is about 0.5cm.

4. The catheter as set forth in claim 1 wherein means are provided securing the proximal end of the thin needle to the first end zone of the tubular length and said means comprise an annular recess in the first end zone of said tubular length and said end zone is of plastic material and a pattern in relief on the proximal end of the needle is provided and said pattern is disposed within said recess and imbedded in the plastic material of said tubular length, with said pattern in relief keying the needle and tubular length together as a unitary piece.

than the span between the wall of said thin needle at its proximal end to nest between the walls and thin needle ends and to bear against the needle for advancing movement when longitudinal force is applied to the styend of a diameter greater than the diameter of the first 5 let.

end of said stylet and the diameter of said stylet is less

Claims (5)

1. A spinal anethesia administering apparatus comprising in combination, a first big needle defining a lumen and a catheter sized for longitudinal movement removable received in the lumen of said big needle, said catheter including, a tubular length having a first end zone and a second end zone and of a diameter smaller than the lumen of the big needle, a thin needle portion on the first end zone of said tubular length having a through passageway and a distal end portion having a tissue wall piercing tip and a proximal end portion and with said through passageway being in fluid transmitting engagement with said tubular length, an elongated stylet having a first end and a second end and with said first end in said tubular length and with said second end being exterior of said tubular length, and said stylet being of a length greater than said tubular length and being sized for longitudinal coaxial movement in the tubular length and being sized less than said through opening in said thin needle portion, and mutually inter-co-operating means on the first end of the stylet and said thin needle for applying a longitudinal force to advance the thin needle and tubular length relative to the big needle after said big needle has been utilized to penetrate to a predetermined depth for a second stage of penetration by said thin needle, whereupon the stylet may be removed from said combination and material be injected through said tubular length and thin needle.
2. The combination as set forth in claim 1 wherein the interco-operating means on the first end of the stylet and said thin needle comprise walls included in said thin needle converging to a constricted opening at the distal end, said opening being of a diameter greater than the diameter of the first end of said stylet and the diameter of said stylet being less than the span between the walls of said thin needle at its proximal end to bear against the wall of the needle for advancing movement of the catheter relative to the big needle when longitudinal force is applied to the stylet.
3. The catheter as set forth in claim 1 wherein the catheter is of about 20 gauge size, the thin needle is of about 25 gauge size and the longitudinal dimension of the small needle is about 0.5cm.
4. The catheter as set forth in claim 1 wherein means are provided securing the proximal end of the thin needle to the first end zone of the tubular length and said means comprise an annular recess in the first end zone of said tubular length and said end zone is of plastic material and a pattern in relief on the proximal end of the needle is provided and said pattern is disposed within said recess and imbedded in the plastic material of said tubular length, with said pattern in relief keying the needle and tubular length together as a unitary piece.
5. The combination as set forth in claim 4 wherein the intercooperating means on the inner end of the stylet and catheter comprises walls included in said thin needle converging to a constricted opening at the distal end of a diameter greater than the diameter of the first end of said stylet and the diameter of said stylet is less than the span between the wall of said thin needle at its proximal end to nest between the walls and thin needle ends and to bear against the needle for advancing movement when longitudinal force is applied to the stylet.
US3780733A 1972-07-24 1972-07-24 Catheter Expired - Lifetime US3780733A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US27443872 true 1972-07-24 1972-07-24

Publications (1)

Publication Number Publication Date
US3780733A true US3780733A (en) 1973-12-25

Family

ID=23048198

Family Applications (1)

Application Number Title Priority Date Filing Date
US3780733A Expired - Lifetime US3780733A (en) 1972-07-24 1972-07-24 Catheter

Country Status (1)

Country Link
US (1) US3780733A (en)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4917670A (en) * 1988-03-22 1990-04-17 Hurley Ronald J Continuous spinal anesthesia administering apparatus and method
US5085631A (en) * 1988-08-02 1992-02-04 Thomas Jefferson University Method and kit for administering spinal subarachnoid anesthesia
US5092848A (en) * 1988-10-13 1992-03-03 Deciutiis Vincent L Intravenous catheter with built-in cutting tip and method for making the same
US5106376A (en) * 1989-07-07 1992-04-21 B. Braun Melsungen Ag Anaesthesia set
US5232442A (en) * 1989-12-11 1993-08-03 Brigham And Women's Hospital Method and apparatus for inducing anesthesia
US5304141A (en) * 1989-12-11 1994-04-19 Brigham And Women's Hospital Method and apparatus for inducing anesthesia
US6500157B2 (en) * 1998-09-03 2002-12-31 Ronald B. Luther Intravenous infusion needle with soft body
US20040039338A1 (en) * 2002-05-21 2004-02-26 Lee Michael J. Deflectable microimplant delivery system
US6855124B1 (en) * 2002-10-02 2005-02-15 Advanced Cardiovascular Systems, Inc. Flexible polymer needle catheter
US7294334B1 (en) 2003-04-15 2007-11-13 Advanced Cardiovascular Systems, Inc. Methods and compositions to treat myocardial conditions
US20080009095A1 (en) * 2006-06-01 2008-01-10 The Johns Hopkins University Advanced Thin Flexible Microelectronic Assemblies and Methods for Making Same
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US20090088698A1 (en) * 2007-09-27 2009-04-02 Tyco Healthcare Group Lp Blood Collection Needle Assembly
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US20110104061A1 (en) * 2009-04-22 2011-05-05 Mercator Medsystems, Inc. Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US8521259B2 (en) 2001-06-20 2013-08-27 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8747385B2 (en) 2003-04-15 2014-06-10 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US9234619B2 (en) * 2014-04-21 2016-01-12 Ching-Jung Chang Tube cap
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US20160066963A1 (en) * 2004-10-20 2016-03-10 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US20160135853A1 (en) * 2004-10-20 2016-05-19 Vertiflex, Inc. Minimally invasive tooling for delivery of interspinous spacer
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US9687630B2 (en) 2005-04-19 2017-06-27 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US9956011B2 (en) 2004-10-20 2018-05-01 Vertiflex, Inc. Interspinous spacer

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2512569A (en) * 1947-09-26 1950-06-20 Jacob A Saffir Hypodermic needle
US2828744A (en) * 1956-02-13 1958-04-01 Hirsch Sidney Flexible needle for use in intravenous therapy
US3181336A (en) * 1961-11-15 1965-05-04 Schofield Hubert Percival Method of producing the pointed end of a hypodermic needle
US3358684A (en) * 1965-03-12 1967-12-19 Marshall Gerald Parenteral injection devices
US3380448A (en) * 1964-11-24 1968-04-30 Abbott Lab Cervical-pudendal indwelling catheter set with tissue piercing means
US3506007A (en) * 1967-07-24 1970-04-14 Henkin Melvyn Lane Catheter-needle
US3584624A (en) * 1969-02-24 1971-06-15 Vincent L De Ciutiis Flexible intravenous catheter provided with cutting tip means

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2512569A (en) * 1947-09-26 1950-06-20 Jacob A Saffir Hypodermic needle
US2828744A (en) * 1956-02-13 1958-04-01 Hirsch Sidney Flexible needle for use in intravenous therapy
US3181336A (en) * 1961-11-15 1965-05-04 Schofield Hubert Percival Method of producing the pointed end of a hypodermic needle
US3380448A (en) * 1964-11-24 1968-04-30 Abbott Lab Cervical-pudendal indwelling catheter set with tissue piercing means
US3358684A (en) * 1965-03-12 1967-12-19 Marshall Gerald Parenteral injection devices
US3506007A (en) * 1967-07-24 1970-04-14 Henkin Melvyn Lane Catheter-needle
US3584624A (en) * 1969-02-24 1971-06-15 Vincent L De Ciutiis Flexible intravenous catheter provided with cutting tip means

Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4917670A (en) * 1988-03-22 1990-04-17 Hurley Ronald J Continuous spinal anesthesia administering apparatus and method
US5085631A (en) * 1988-08-02 1992-02-04 Thomas Jefferson University Method and kit for administering spinal subarachnoid anesthesia
US5092848A (en) * 1988-10-13 1992-03-03 Deciutiis Vincent L Intravenous catheter with built-in cutting tip and method for making the same
US5106376A (en) * 1989-07-07 1992-04-21 B. Braun Melsungen Ag Anaesthesia set
US5304141A (en) * 1989-12-11 1994-04-19 Brigham And Women's Hospital Method and apparatus for inducing anesthesia
US5232442A (en) * 1989-12-11 1993-08-03 Brigham And Women's Hospital Method and apparatus for inducing anesthesia
US6500157B2 (en) * 1998-09-03 2002-12-31 Ronald B. Luther Intravenous infusion needle with soft body
US20030153879A1 (en) * 1998-09-03 2003-08-14 Luther Ronald B. Intravenous infusion needle with soft body
US6863662B2 (en) * 1998-09-03 2005-03-08 Ronald B. Luther Intravenous infusion needle with soft body
US8521259B2 (en) 2001-06-20 2013-08-27 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US20040039338A1 (en) * 2002-05-21 2004-02-26 Lee Michael J. Deflectable microimplant delivery system
US7033345B2 (en) 2002-05-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Deflectable microimplant delivery system
US20060095004A1 (en) * 2002-05-21 2006-05-04 Lee Michael J Deflectable microimplant delivery system
US8002739B2 (en) 2002-05-21 2011-08-23 Abbott Cardiovascular Systems Inc. Deflectable microimplant delivery system
US8637069B2 (en) 2002-06-28 2014-01-28 Abbott Cardiovascular Systems Inc. Device and method for combining a treatment agent and a gel
US8715265B2 (en) 2002-06-28 2014-05-06 Abbott Cardiovascular Systems Inc. Device and method for combining a treatment agent and a gel
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US8500680B2 (en) 2002-06-28 2013-08-06 Abbott Cardiovascular Systems Inc. Device and method for combining a treatment agent and a gel
US7850644B2 (en) * 2002-10-02 2010-12-14 Abbott Cardiovascular Systems Inc. Flexible polymer needle catheter
US20050124977A1 (en) * 2002-10-02 2005-06-09 Fernando Gonzalez Flexible polymer needle catheter
US6855124B1 (en) * 2002-10-02 2005-02-15 Advanced Cardiovascular Systems, Inc. Flexible polymer needle catheter
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7294334B1 (en) 2003-04-15 2007-11-13 Advanced Cardiovascular Systems, Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US8747385B2 (en) 2003-04-15 2014-06-10 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8795652B1 (en) 2003-04-15 2014-08-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US10039576B2 (en) * 2004-10-20 2018-08-07 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US9956011B2 (en) 2004-10-20 2018-05-01 Vertiflex, Inc. Interspinous spacer
US20160066963A1 (en) * 2004-10-20 2016-03-10 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US20160135853A1 (en) * 2004-10-20 2016-05-19 Vertiflex, Inc. Minimally invasive tooling for delivery of interspinous spacer
US10080587B2 (en) * 2004-10-20 2018-09-25 Vertiflex, Inc. Methods for treating a patient's spine
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US8609126B2 (en) 2005-04-19 2013-12-17 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9687630B2 (en) 2005-04-19 2017-06-27 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080009095A1 (en) * 2006-06-01 2008-01-10 The Johns Hopkins University Advanced Thin Flexible Microelectronic Assemblies and Methods for Making Same
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8486387B2 (en) 2006-07-31 2013-07-16 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8486386B2 (en) 2006-07-31 2013-07-16 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9775930B2 (en) 2006-11-17 2017-10-03 Abbott Cardiovascular Systems Inc. Composition for modifying myocardial infarction expansion
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8465773B2 (en) 2006-12-04 2013-06-18 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8828436B2 (en) 2006-12-04 2014-09-09 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8465772B2 (en) 2006-12-04 2013-06-18 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US9066690B2 (en) 2007-09-27 2015-06-30 Covidien Lp Blood collection needle assembly
US20090088698A1 (en) * 2007-09-27 2009-04-02 Tyco Healthcare Group Lp Blood Collection Needle Assembly
US9011879B2 (en) 2009-04-22 2015-04-21 Mercator Medsystems, Inc. Treatment of renal hypertension or carotid sinus syndrome with heated fluid sympathetic denervation or neuromodulation
US8399443B2 (en) 2009-04-22 2013-03-19 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
US20110104061A1 (en) * 2009-04-22 2011-05-05 Mercator Medsystems, Inc. Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
US8465752B2 (en) 2009-04-22 2013-06-18 Mercator Medsystems, Inc. Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
US9199065B2 (en) 2009-04-22 2015-12-01 Mercator Medsystems, Inc. Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
US20110104060A1 (en) * 2009-04-22 2011-05-05 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
US9234619B2 (en) * 2014-04-21 2016-01-12 Ching-Jung Chang Tube cap

Similar Documents

Publication Publication Date Title
US3572335A (en) Cervical implant method and device
US3515137A (en) Intravenous catheter unit with inserter means for sequential feeding of catheter
US3333588A (en) Brain ventricle cannula
US3312220A (en) Disposable indwelling plastic cannula assembly
US3539034A (en) Paracervical block anesthesia assembly
US3225762A (en) Intravenous stylet catheter
US3459184A (en) Intravenous catheter placement unit
US5250035A (en) Cannula and stylet system
US5919172A (en) Hypodermic needle having a differential surface finish
US6017359A (en) Vascular sealing apparatus
US5080654A (en) Fluid injection device for intravenous delivery system
US6558353B2 (en) Spinal needle
US5620419A (en) Port stabilizer ring
US7359755B2 (en) Method and apparatus for implanting an electrical stimulation lead using a flexible introducer
US5628734A (en) Spinal needle with curved distal end and method of using said needle in a spinal injection to prevent post dural puncture headache
US5755727A (en) Method device for locating and sealing a blood vessel
US5419763A (en) Prostatic drug-delivery catheter
US6273715B1 (en) Disposable anesthesia delivery system with shortened outer sleeve and inner hollow drill
US4888000A (en) Apparatus for the insertion of catheters
US5255691A (en) Percutaneous epidural lead introducing system and method
US3920001A (en) Aspirator device
Mey et al. Evaluation of an ultrasound-guided technique for central venous access via the internal jugular vein in 493 patients
US5378241A (en) Anesthesia instrument
US3633579A (en) Catheter placement device and method
US5290244A (en) Syringe and needle with guide wire for cannulation of central veins