BRPI1014635A2 - compostos heterocíclicos e de expansão para células-tronco hematopoiéticas - Google Patents
compostos heterocíclicos e de expansão para células-tronco hematopoiéticasInfo
- Publication number
- BRPI1014635A2 BRPI1014635A2 BRPI1014635A BRPI1014635A BRPI1014635A2 BR PI1014635 A2 BRPI1014635 A2 BR PI1014635A2 BR PI1014635 A BRPI1014635 A BR PI1014635A BR PI1014635 A BRPI1014635 A BR PI1014635A BR PI1014635 A2 BRPI1014635 A2 BR PI1014635A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic
- stem cells
- hematopoietic stem
- expansion
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009135495 | 2009-06-04 | ||
| PCT/JP2010/059552 WO2010140685A1 (ja) | 2009-06-04 | 2010-06-04 | ヘテロ環化合物及び造血幹細胞の増幅剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1014635A2 true BRPI1014635A2 (pt) | 2016-04-05 |
| BRPI1014635A8 BRPI1014635A8 (pt) | 2016-10-11 |
Family
ID=43297817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1014635A BRPI1014635A8 (pt) | 2009-06-04 | 2010-06-04 | compostos heterocíclicos e agentes de expansão para células-tronco hematopoiéticas |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20120128640A1 (pt) |
| EP (1) | EP2439204B1 (pt) |
| JP (1) | JP5737177B2 (pt) |
| CN (1) | CN102448949B (pt) |
| AU (1) | AU2010254920C1 (pt) |
| BR (1) | BRPI1014635A8 (pt) |
| CA (1) | CA2760655C (pt) |
| IL (1) | IL216131A0 (pt) |
| WO (1) | WO2010140685A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435496B2 (en) * | 2005-01-12 | 2008-10-14 | Toyota Motor Engineering & Manufacturing North America, Inc. | Anhydrous proton conductor based on heterocycle attached to a polymer backbone |
| JP5876498B2 (ja) * | 2011-10-03 | 2016-03-02 | 日産化学工業株式会社 | 多能性幹細胞からの巨核球及び／又は血小板の製造方法 |
| DE102012103405A1 (de) * | 2012-04-18 | 2013-10-24 | Heinrich-Pette-Institut | Desoxyhypusin-Synthase-Inhibitoren |
| JP5511039B1 (ja) * | 2013-05-22 | 2014-06-04 | 国立大学法人九州大学 | Ｎｋ細胞の調製方法 |
| WO2019196816A1 (zh) * | 2018-04-13 | 2019-10-17 | 诺未科技（北京）有限公司 | 丁酸钠的用途及含有丁酸钠的培养体系 |
| CN110972481B (zh) * | 2018-09-17 | 2020-10-20 | 诺未科技（北京）有限公司 | 一种组合物及其用途 |
| CN114302882A (zh) * | 2019-07-19 | 2022-04-08 | 威佛（国际）股份公司 | 用于治疗输血依赖型β-地中海贫血（tdt）的膜铁转运蛋白抑制剂 |
| WO2021224416A1 (en) | 2020-05-06 | 2021-11-11 | Cellectis S.A. | Methods to genetically modify cells for delivery of therapeutic proteins |
| EP4146812A1 (en) | 2020-05-06 | 2023-03-15 | Cellectis S.A. | Methods for targeted insertion of exogenous sequences in cellular genomes |
| WO2022085781A1 (ja) * | 2020-10-23 | 2022-04-28 | 日産化学株式会社 | 造血障害の治療剤 |
| CN114196632A (zh) * | 2021-11-02 | 2022-03-18 | 济南赛尔生物科技股份有限公司 | 一种高效体外培养造血干细胞的培养基 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| US6060052A (en) * | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
| EP1069821B1 (en) | 1998-02-17 | 2011-06-08 | Gamida Cell Ltd. | Method of controlling proliferation and differentiation of stem and progenitor cells |
| JP2000023674A (ja) | 1998-07-13 | 2000-01-25 | Kirin Brewery Co Ltd | 分化を抑制するペプチドと造血幹細胞増殖法 |
| JP4453135B2 (ja) | 1999-12-09 | 2010-04-21 | 東ソー株式会社 | 造血細胞の新規増幅剤 |
| JP2004222502A (ja) * | 2003-01-17 | 2004-08-12 | Asahi Kasei Corp | 造血幹細胞増幅法 |
| UA82695C2 (uk) | 2003-06-06 | 2008-05-12 | Нисан Кемикал Индастриз, Лтд. | Гетероароматичні сполуки як активатори рецептора тромбопоетину |
| JP4651282B2 (ja) | 2004-01-21 | 2011-03-16 | 田辺三菱製薬株式会社 | 造血幹細胞及び造血前駆細胞の増幅方法 |
| KR101215207B1 (ko) | 2004-12-14 | 2012-12-26 | 닛산 가가쿠 고교 가부시키 가이샤 | 아미드 화합물 및 트롬보포이에틴 리셉터 활성화제 |
| UA91054C2 (ru) * | 2005-07-15 | 2010-06-25 | Ниссан Кемикал Индастрис, Лтд. | Тиофеновые соединения и активаторы рецептора тромбопоэтина |
| NZ563202A (en) * | 2005-07-15 | 2011-02-25 | Nissan Chemical Ind Ltd | Thiophene compounds and thrombopoietin receptor activators |
| JP5104752B2 (ja) * | 2005-07-20 | 2012-12-19 | 日産化学工業株式会社 | ピラゾール化合物及びトロンボポエチンレセプター活性化剤 |
| WO2007079199A2 (en) * | 2005-12-30 | 2007-07-12 | Alantos Pharmaceuticals, Holding, Inc. | Substituted bis-amide metalloprotease inhibitors |
| JP2009040692A (ja) | 2007-08-06 | 2009-02-26 | Hiroshima Univ | ヒト末梢血由来ｃｄ１３３／ｃｄ３４陽性細胞移植による筋損傷の修復 |
| US20090142482A1 (en) | 2007-11-30 | 2009-06-04 | Xerox Corporation | Methods of Printing Conductive Silver Features |
| EP2228435A4 (en) * | 2007-12-05 | 2013-01-23 | Nissan Chemical Ind Ltd | METHOD FOR AMPLIFYING HEMATOPOIETIC STRAIN CELL USING HETEROCYCLIC COMPOUND |
| WO2009072626A1 (ja) * | 2007-12-05 | 2009-06-11 | Nissan Chemical Industries, Ltd. | ヘテロ環化合物による造血幹細胞の増幅方法 |
| CA2708050C (en) * | 2007-12-06 | 2016-08-16 | Nissan Chemical Industries, Ltd. | Method for expanding hematopoietic stem cells using heterocyclic compound |
-
2010
- 2010-06-04 CA CA2760655A patent/CA2760655C/en active Active
- 2010-06-04 EP EP10783467.3A patent/EP2439204B1/en active Active
- 2010-06-04 WO PCT/JP2010/059552 patent/WO2010140685A1/ja not_active Ceased
- 2010-06-04 CN CN201080025055.8A patent/CN102448949B/zh active Active
- 2010-06-04 AU AU2010254920A patent/AU2010254920C1/en not_active Ceased
- 2010-06-04 JP JP2011518517A patent/JP5737177B2/ja active Active
- 2010-06-04 US US13/376,280 patent/US20120128640A1/en not_active Abandoned
- 2010-06-04 BR BRPI1014635A patent/BRPI1014635A8/pt not_active IP Right Cessation
-
2011
- 2011-11-03 IL IL216131A patent/IL216131A0/en unknown
-
2013
- 2013-05-02 US US13/875,387 patent/US9328085B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2439204A1 (en) | 2012-04-11 |
| JP5737177B2 (ja) | 2015-06-17 |
| BRPI1014635A8 (pt) | 2016-10-11 |
| US20120128640A1 (en) | 2012-05-24 |
| IL216131A0 (en) | 2012-01-31 |
| CN102448949B (zh) | 2014-09-03 |
| CA2760655A1 (en) | 2010-12-09 |
| US9328085B2 (en) | 2016-05-03 |
| US20130245255A1 (en) | 2013-09-19 |
| EP2439204B1 (en) | 2017-01-04 |
| CA2760655C (en) | 2018-03-06 |
| AU2010254920B2 (en) | 2015-10-08 |
| AU2010254920A1 (en) | 2011-11-24 |
| WO2010140685A1 (ja) | 2010-12-09 |
| CN102448949A (zh) | 2012-05-09 |
| AU2010254920C1 (en) | 2016-03-10 |
| JPWO2010140685A1 (ja) | 2012-11-22 |
| EP2439204A4 (en) | 2012-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |