BRPI0923480A2 - formas polimorficas de di-hidrogenofosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirimidin-2-il]-benzil}-2h-piridazin-3-ona e processos de fabricacao das mesmas - Google Patents
formas polimorficas de di-hidrogenofosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirimidin-2-il]-benzil}-2h-piridazin-3-ona e processos de fabricacao das mesmasInfo
- Publication number
- BRPI0923480A2 BRPI0923480A2 BRPI0923480A BRPI0923480A BRPI0923480A2 BR PI0923480 A2 BRPI0923480 A2 BR PI0923480A2 BR PI0923480 A BRPI0923480 A BR PI0923480A BR PI0923480 A BRPI0923480 A BR PI0923480A BR PI0923480 A2 BRPI0923480 A2 BR PI0923480A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridazin
- morpholin
- pyrazol
- pyrimidin
- ethoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08022253.2 | 2008-12-22 | ||
EP08022253 | 2008-12-22 | ||
PCT/EP2009/008358 WO2010072295A1 (en) | 2008-12-22 | 2009-11-24 | Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0923480A2 true BRPI0923480A2 (pt) | 2016-08-09 |
BRPI0923480B1 BRPI0923480B1 (pt) | 2020-10-13 |
BRPI0923480B8 BRPI0923480B8 (pt) | 2021-05-25 |
Family
ID=41609799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0923480A BRPI0923480B8 (pt) | 2008-12-22 | 2009-11-24 | formas polimórficas de di-hidrogenofosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etóxi)-pirimidin-2-il]-benzil}-2h-piridazin-3-ona, seus processos de fabricação, composição farmacêutica, medicamento, e kit |
Country Status (32)
Country | Link |
---|---|
US (1) | US8586599B2 (pt) |
EP (1) | EP2361250B1 (pt) |
JP (2) | JP5690741B2 (pt) |
KR (1) | KR101663335B1 (pt) |
CN (1) | CN102264729B (pt) |
AR (1) | AR074686A1 (pt) |
AU (1) | AU2009331990B2 (pt) |
BR (1) | BRPI0923480B8 (pt) |
CA (1) | CA2748218C (pt) |
CL (1) | CL2011001278A1 (pt) |
CO (1) | CO6331435A2 (pt) |
CY (1) | CY1114659T1 (pt) |
DK (1) | DK2361250T3 (pt) |
EA (1) | EA019320B1 (pt) |
EC (1) | ECSP11011219A (pt) |
ES (1) | ES2434247T3 (pt) |
HK (1) | HK1164837A1 (pt) |
HR (1) | HRP20130993T1 (pt) |
IL (1) | IL213647A (pt) |
MX (1) | MX2011006682A (pt) |
MY (1) | MY160526A (pt) |
NZ (1) | NZ594172A (pt) |
PE (1) | PE20120016A1 (pt) |
PL (1) | PL2361250T3 (pt) |
PT (1) | PT2361250E (pt) |
SG (1) | SG172128A1 (pt) |
SI (1) | SI2361250T1 (pt) |
SM (1) | SMT201300133B (pt) |
TW (1) | TWI448463B (pt) |
UA (1) | UA103646C2 (pt) |
WO (1) | WO2010072295A1 (pt) |
ZA (1) | ZA201105394B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102008062826A1 (de) * | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
KR20180092096A (ko) * | 2017-02-08 | 2018-08-17 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
EP3697776B1 (en) | 2017-10-17 | 2023-04-19 | Palau Pharma, S.L.U. | Synthesis of 4-aminopyrimidine compounds |
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TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
AUPQ462299A0 (en) | 1999-12-13 | 2000-01-13 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
US6242461B1 (en) | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
US20040259863A1 (en) | 2001-10-31 | 2004-12-23 | Hans-Michael Eggenweiler | Type 4 phosphodiesterase inhibitors and uses thereof |
BR0317525A (pt) | 2002-12-20 | 2005-11-16 | Pharmacia Corp | Compostos pirazol acìclico, composição terapêutica e farmacêutica, kit, bem como respectivos usos |
US7250417B2 (en) | 2003-07-02 | 2007-07-31 | Sugen Inc. | Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors |
US7959919B2 (en) | 2003-11-19 | 2011-06-14 | Novelmed Therapeutics, Inc. | Method of inhibiting factor B-mediated complement activation |
WO2006015263A2 (en) | 2004-07-29 | 2006-02-09 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
US20070015771A1 (en) | 2004-07-29 | 2007-01-18 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
US20070043057A1 (en) | 2005-02-09 | 2007-02-22 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
WO2007044796A2 (en) | 2005-10-11 | 2007-04-19 | Nps Pharmaceuticals, Inc. | Pyridazinone compounds as calcilytics |
EP1963329B1 (en) | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
DE102005057924A1 (de) | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
MX2008008277A (es) | 2005-12-21 | 2009-03-04 | Janssen Pharmaceutica Nv | Triazolopiridazinas como moduladores de tirosina cinasa. |
WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
PE20091079A1 (es) | 2007-10-16 | 2009-08-24 | Novartis Ag | Compuestos heterociclicos como moduladores npy y2 |
ATE523508T1 (de) | 2007-10-25 | 2011-09-15 | Astrazeneca Ab | Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate |
RU2010121763A (ru) | 2007-10-31 | 2011-12-10 | Ниссан Кемикал Индастриз, Лтд. (Jp) | Производные пиридазинона и ингибиторы р2х7 рецептора |
AR069545A1 (es) | 2007-11-16 | 2010-02-03 | Boehringer Ingelheim Pharma | Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y |
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BRPI1013159A2 (pt) | 2009-03-30 | 2015-09-15 | Sumitomo Chemical Co | Uso de composto de piridazinona para controle de peste artrópode |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
-
2009
- 2009-11-24 MX MX2011006682A patent/MX2011006682A/es active IP Right Grant
- 2009-11-24 UA UAA201109101A patent/UA103646C2/ru unknown
- 2009-11-24 PL PL09756445T patent/PL2361250T3/pl unknown
- 2009-11-24 WO PCT/EP2009/008358 patent/WO2010072295A1/en active Application Filing
- 2009-11-24 EP EP09756445.4A patent/EP2361250B1/en active Active
- 2009-11-24 AU AU2009331990A patent/AU2009331990B2/en not_active Ceased
- 2009-11-24 ES ES09756445T patent/ES2434247T3/es active Active
- 2009-11-24 EA EA201100973A patent/EA019320B1/ru not_active IP Right Cessation
- 2009-11-24 SI SI200930754T patent/SI2361250T1/sl unknown
- 2009-11-24 SG SG2011043171A patent/SG172128A1/en unknown
- 2009-11-24 DK DK09756445.4T patent/DK2361250T3/da active
- 2009-11-24 CA CA2748218A patent/CA2748218C/en active Active
- 2009-11-24 JP JP2011542688A patent/JP5690741B2/ja active Active
- 2009-11-24 KR KR1020117017081A patent/KR101663335B1/ko active IP Right Grant
- 2009-11-24 US US13/141,142 patent/US8586599B2/en active Active
- 2009-11-24 PE PE2011001264A patent/PE20120016A1/es not_active Application Discontinuation
- 2009-11-24 CN CN200980151790.0A patent/CN102264729B/zh active Active
- 2009-11-24 BR BRPI0923480A patent/BRPI0923480B8/pt active IP Right Grant
- 2009-11-24 NZ NZ594172A patent/NZ594172A/xx not_active IP Right Cessation
- 2009-11-24 MY MYPI2011002864A patent/MY160526A/en unknown
- 2009-11-24 PT PT97564454T patent/PT2361250E/pt unknown
- 2009-12-16 AR ARP090104909A patent/AR074686A1/es not_active Application Discontinuation
- 2009-12-21 TW TW098143944A patent/TWI448463B/zh not_active IP Right Cessation
-
2011
- 2011-05-31 CL CL2011001278A patent/CL2011001278A1/es unknown
- 2011-06-19 IL IL213647A patent/IL213647A/en active IP Right Grant
- 2011-06-22 CO CO11078454A patent/CO6331435A2/es active IP Right Grant
- 2011-07-21 EC EC2011011219A patent/ECSP11011219A/es unknown
- 2011-07-21 ZA ZA2011/05394A patent/ZA201105394B/en unknown
-
2012
- 2012-05-28 HK HK12105184.1A patent/HK1164837A1/xx not_active IP Right Cessation
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2013
- 2013-10-21 HR HRP20130993AT patent/HRP20130993T1/hr unknown
- 2013-11-07 CY CY20131100991T patent/CY1114659T1/el unknown
- 2013-11-13 SM SM201300133T patent/SMT201300133B/xx unknown
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2014
- 2014-11-14 JP JP2014231392A patent/JP5860125B2/ja active Active
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