BRPI0922043B1 - Composições compreendendo um aril pirazol e/ou formamidina, métodos e usos das mesmas - Google Patents
Composições compreendendo um aril pirazol e/ou formamidina, métodos e usos das mesmas Download PDFInfo
- Publication number
- BRPI0922043B1 BRPI0922043B1 BRPI0922043-7A BRPI0922043A BRPI0922043B1 BR PI0922043 B1 BRPI0922043 B1 BR PI0922043B1 BR PI0922043 A BRPI0922043 A BR PI0922043A BR PI0922043 B1 BRPI0922043 B1 BR PI0922043B1
- Authority
- BR
- Brazil
- Prior art keywords
- approximately
- cavity
- compound
- veterinarily acceptable
- formamidine
- Prior art date
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- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catching Or Destruction (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11603808P | 2008-11-19 | 2008-11-19 | |
| US61/116,038 | 2008-11-19 | ||
| US14256109P | 2009-01-05 | 2009-01-05 | |
| US61/142,561 | 2009-01-05 | ||
| US16738109P | 2009-04-07 | 2009-04-07 | |
| US61/167,381 | 2009-04-07 | ||
| PCT/US2009/064443 WO2010059529A2 (en) | 2008-11-19 | 2009-11-13 | Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0922043A2 BRPI0922043A2 (pt) | 2015-12-22 |
| BRPI0922043B1 true BRPI0922043B1 (pt) | 2019-04-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0922043-7A BRPI0922043B1 (pt) | 2008-11-19 | 2009-11-13 | Composições compreendendo um aril pirazol e/ou formamidina, métodos e usos das mesmas |
Country Status (23)
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| BR (1) | BRPI0922043B1 (enExample) |
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| CO (1) | CO6382116A2 (enExample) |
| CR (1) | CR20110273A (enExample) |
| ES (1) | ES2781828T3 (enExample) |
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| TW (1) | TWI505777B (enExample) |
| WO (1) | WO2010059529A2 (enExample) |
| ZA (2) | ZA201103618B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| FR2909975B1 (fr) * | 2006-12-13 | 2009-04-17 | Eskiss Packaging Soc Par Actio | Flacon destine a recevoir une dose determinee d'un liquide |
| WO2009070687A1 (en) * | 2007-11-26 | 2009-06-04 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| SG171751A1 (en) * | 2008-11-19 | 2011-07-28 | Merial Ltd | Compositions comprising an aryl pyrazole and/ or a formamidine methods and uses thereof |
| US9173728B2 (en) * | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| EP2416663A2 (en) * | 2009-03-18 | 2012-02-15 | Martin Benedict George Donnelly | Parasiticidal formulation |
| JP2011153129A (ja) * | 2009-12-28 | 2011-08-11 | Sumitomo Chemical Co Ltd | 動物外部寄生虫防除組成物 |
| UY33443A (es) * | 2010-06-19 | 2012-01-31 | Bayer Animal Health Gmbh | Preparacion que contiene ectoparasiticida para la formacion de emulsion espontanea |
| PH12013501948A1 (en) * | 2011-04-15 | 2013-10-14 | Colgate Palmolive Co | Oral care kit |
| CH705153A1 (fr) * | 2011-06-24 | 2012-12-31 | Heidi Hall | Mors et système pour envoyer une substance visqueuse et/ou liquide dans la bouche d'un animal. |
| US9034912B1 (en) * | 2012-03-23 | 2015-05-19 | Jugal K. Taneja | Veterinary composition and method |
| BR112014024833B1 (pt) | 2012-04-04 | 2022-10-04 | Intervet International B.V. | Produto farmacêutico veterinário mastigável macio, processo para sua fabricação e seu uso, bem como uso de pamoato de sódio |
| US20130292414A1 (en) * | 2012-05-02 | 2013-11-07 | Spencer D. Sutherland | Dispensing Device |
| US9622478B2 (en) | 2012-10-16 | 2017-04-18 | Solano S.P. Ltd. | Topical formulations for treating parasitic infestations |
| WO2015007923A1 (es) * | 2013-07-18 | 2015-01-22 | König Lab, S.L. | Procedimiento de desparasitación de animales mediante la aplicación simultánea de dos o más agentes parasiticidas por vía dérmica y dispositivo para su puesta en práctica |
| RU2688167C1 (ru) | 2013-12-20 | 2019-05-20 | Интервет Интернэшнл Б.В. | Применение изоксазолиновых соединений на домашней птице |
| JP6581586B2 (ja) * | 2013-12-20 | 2019-09-25 | インターベット インターナショナル ベー. フェー. | イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用 |
| USD765520S1 (en) * | 2014-01-07 | 2016-09-06 | The Coca-Cola Company | Blister package |
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| JP6722464B2 (ja) * | 2016-01-28 | 2020-07-15 | 株式会社大阪製薬 | 動物用害虫防除具 |
| WO2017187435A1 (en) | 2016-04-24 | 2017-11-02 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
| CA3053152A1 (en) * | 2017-02-13 | 2018-08-16 | Aurelie De Malibran-Santibanez | Liquid applicator for delivering vaccines |
| CN119157876A (zh) | 2017-12-15 | 2024-12-20 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| CA3096523C (en) * | 2018-04-12 | 2023-07-11 | Glenn Andrew Bradshaw | Animal treatment apparatus, block, and method of use |
| JP7199653B2 (ja) * | 2018-08-17 | 2023-01-06 | 住化エンバイロメンタルサイエンス株式会社 | 樹脂製容器入り外部寄生虫駆除剤 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| KR102056732B1 (ko) * | 2019-07-10 | 2019-12-17 | (주)알메디카 | 환자 맞춤형 약액을 수용하기 위한 일회용 약액 용기, 이를 제작하는 장치, 및 제작 방법 |
| JP7857414B2 (ja) * | 2022-02-17 | 2026-05-12 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US404972A (en) | 1889-06-11 | howard | ||
| FR2753377B1 (fr) * | 1996-09-19 | 1999-09-24 | Rhone Merieux | Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides |
| US6426333B1 (en) * | 1996-09-19 | 2002-07-30 | Merial | Spot-on formulations for combating parasites |
| DE404972C (de) * | 1921-06-17 | 1924-10-28 | Otto Zinsheimer | Aufzugsgeruest, insbesondere fuer Dachdeckerarbeiten |
| US3318769A (en) | 1963-05-31 | 1967-05-09 | Shell Oil Co | Resin compositions comprising organo-phosphorus pesticides |
| US3781355A (en) * | 1969-12-12 | 1973-12-25 | Boots Pure Drug Co Ltd | Pesticidal compounds and compositions |
| NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| US3864497A (en) * | 1970-12-01 | 1975-02-04 | Boots Pure Drug Co Ltd | Acaricidal and insecticidal 1,5-diphenyl-3-methyl-1,3,5-triazapenta-1,4-diener |
| US3852416A (en) | 1971-05-27 | 1974-12-03 | L Grubb | Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide |
| JPS4914624A (enExample) | 1972-06-08 | 1974-02-08 | ||
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
| US4150109A (en) | 1974-05-07 | 1979-04-17 | Dick Pierre R G | Devices for protecting animals from ectoparasites |
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| CH604517A5 (enExample) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
| JPS5338621A (en) | 1976-09-16 | 1978-04-08 | Nissan Chem Ind Ltd | Miticidal composition |
| JPS5341428A (en) | 1976-09-27 | 1978-04-14 | Nissan Chem Ind Ltd | Miticidal composition |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| GB1576393A (en) * | 1977-07-01 | 1980-10-08 | Boots Co Ltd | Pesticidal compositions |
| JPS5444021A (en) | 1977-09-10 | 1979-04-07 | Nissan Chem Ind Ltd | Miticidal composition |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| JPS54101426A (en) | 1978-01-24 | 1979-08-10 | Nissan Chem Ind Ltd | Miticidal composition |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| DE3235931A1 (de) | 1982-09-29 | 1984-03-29 | Bayer Ag, 5090 Leverkusen | Koeder zur bekaempfung von ungeziefer |
| JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
| EP0179022B1 (de) | 1984-10-18 | 1990-11-07 | Ciba-Geigy Ag | Benzoylphenylharnstoffe |
| EP0192060B1 (de) | 1985-02-04 | 1991-09-18 | Nihon Bayer Agrochem K.K. | Heterocyclische Verbindungen |
| US4620057A (en) | 1985-06-07 | 1986-10-28 | Phillips Petroleum Company | Methane conversion |
| GB8713768D0 (en) | 1987-06-12 | 1987-07-15 | May & Baker Ltd | Compositions of matter |
| GB8531485D0 (en) | 1985-12-20 | 1986-02-05 | May & Baker Ltd | Compositions of matter |
| US6372774B1 (en) | 1985-12-20 | 2002-04-16 | Rhone-Poulenc Agriculture Ltd. | Derivatives of N-phenylpyrazoles |
| US5547974A (en) | 1985-12-20 | 1996-08-20 | Rhone-Poulenc Agriculture Ltd. | Derivatives of N-phenylpyrazoles |
| US5232940A (en) | 1985-12-20 | 1993-08-03 | Hatton Leslie R | Derivatives of N-phenylpyrazoles |
| DE3600287A1 (de) * | 1986-01-08 | 1987-07-16 | Bayer Ag | 1-arylpyrazole |
| EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| ES2019932B3 (es) | 1986-03-25 | 1991-07-16 | Sankyo Co | Compuestos macrolidos. |
| GB8613914D0 (en) | 1986-06-07 | 1986-07-09 | Coopers Animal Health | Liquid formulations |
| DE3778768D1 (de) | 1986-07-02 | 1992-06-11 | Ciba Geigy Ag | Pestizide. |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) * | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| EP0319142B1 (en) * | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
| SE8802173D0 (sv) | 1988-06-10 | 1988-06-10 | Astra Ab | Pyrimidine derivatives |
| GB8816915D0 (en) | 1988-07-15 | 1988-08-17 | May & Baker Ltd | New compositions of matter |
| GB2220856A (en) | 1988-07-18 | 1990-01-24 | Merck & Co Inc | Novel synergistic agricultural insecticidal and acaricidal combinations containing avermectin derivatives |
| NZ232422A (en) * | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| US4918085A (en) * | 1989-03-02 | 1990-04-17 | Rhone-Poulenc Ag Company | Pesticidal 3-cyano-5-alkoxy-1-arylpyrazoles, compositions and use |
| AU631259B2 (en) | 1989-12-18 | 1992-11-19 | Ciba-Geigy Ag | Formulations of benzoylphenyl ureas for combating ectoparasites |
| IE904606A1 (en) | 1989-12-21 | 1991-07-03 | Beecham Group Plc | Novel products |
| CA2036147A1 (en) | 1990-06-29 | 1991-12-30 | Hiroki Tomioka | A 1-pyridylimidazole derivative and its production and use |
| IT1243064B (it) | 1990-10-02 | 1994-05-23 | Sarong Spa | Apparecchiatura per la formatura di alveoli in nastri senza soluzione di continuita', in particolare per il confezionamento di prodotti iniettabili come supposte, ovuli o simili |
| NO179282C (no) | 1991-01-18 | 1996-09-11 | Rhone Poulenc Agrochimie | Nye 1-(2-pyridyl)pyrazolforbindelser til kontroll av skadeinsekter |
| NZ247278A (en) | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
| US5236938A (en) * | 1991-04-30 | 1993-08-17 | Rhone-Poulenc Inc. | Pesticidal 1-aryl-5-(substituted alkylideneimino)pyrazoles |
| WO1992022555A1 (en) | 1991-06-17 | 1992-12-23 | Beecham Group Plc | Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents |
| US5246255A (en) | 1991-06-24 | 1993-09-21 | Forbes Christopher B | Repair flange |
| US5411737A (en) | 1991-10-15 | 1995-05-02 | Merck & Co., Inc. | Slow release syneresing polymeric drug delivery device |
| MX9206034A (es) | 1991-10-24 | 1993-05-01 | Roussel Uclaf | Sistema para el control de plagas. |
| US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
| CN1079776A (zh) | 1993-01-03 | 1993-12-22 | 苏州市畜牧兽医站 | 犬、猫专用药物洗涤剂 |
| US5353961A (en) | 1993-01-15 | 1994-10-11 | Reseal International Limited Partnership | Dual chamber dispenser |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| US5318203A (en) * | 1993-07-01 | 1994-06-07 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Dual chamber dispenser |
| US5714919A (en) * | 1993-10-12 | 1998-02-03 | Matsushita Electric Industrial Co., Ltd. | Dielectric notch resonator and filter having preadjusted degree of coupling |
| US5399582A (en) | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
| JP3715994B2 (ja) * | 1993-12-21 | 2005-11-16 | 住友化学株式会社 | 害虫防除剤 |
| AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| US5962499A (en) | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
| MY113806A (en) | 1995-07-21 | 2002-05-31 | Upjohn Co | Antiparasitic marcfortines and paraherquamides |
| US6230935B1 (en) * | 1995-07-28 | 2001-05-15 | Colgate-Palmolive Company | Dual chamber pump dispenser |
| FR2739255B1 (fr) | 1995-09-29 | 1998-09-04 | Rhone Merieux | Composition antiparasitaire pour le traitement et la protection des animaux de compagnie |
| US5817688A (en) | 1995-12-19 | 1998-10-06 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
| ATE236883T1 (de) | 1995-12-19 | 2003-04-15 | Bayer Cropscience Sa | Neue 1-aryl pyrazol derivate und ihre verwendung als schädlingsbekämpfungsmittel |
| US5922885A (en) | 1995-12-19 | 1999-07-13 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
| US5814652A (en) | 1995-12-20 | 1998-09-29 | Rhone-Poulenc Inc. | Pesticidal 5-amino-4-ethylsulfinyl-1-arylpyrazoles |
| DE19548872A1 (de) * | 1995-12-27 | 1997-07-03 | Bayer Ag | Synergistische insektizide Mischungen |
| US6413542B1 (en) | 1996-03-29 | 2002-07-02 | Merial | Direct pour-on antiparasitic skin solution and methods for treating, preventing and controlling myasis |
| FR2752525B1 (fr) * | 1996-08-20 | 2000-05-05 | Rhone Merieux | Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede |
| IE80657B1 (en) | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
| US5885607A (en) | 1996-03-29 | 1999-03-23 | Rhone Merieux | N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs |
| US6010710A (en) | 1996-03-29 | 2000-01-04 | Merial | Direct pour-on skin solution for antiparasitic use in cattle and sheep |
| AU714618B2 (en) * | 1996-07-15 | 2000-01-06 | Sankyo Company Limited | Medicinal composition |
| US6998131B2 (en) * | 1996-09-19 | 2006-02-14 | Merial Limited | Spot-on formulations for combating parasites |
| JP4126621B2 (ja) * | 1996-11-25 | 2008-07-30 | 日本農薬株式会社 | 殺虫・殺ダニ剤 |
| GB9625045D0 (en) | 1996-11-30 | 1997-01-22 | Pfizer Ltd | Parasiticidal compounds |
| US6069157A (en) * | 1997-11-25 | 2000-05-30 | Pfizer Inc. | Parasiticidal compounds |
| IL130533A (en) | 1996-12-24 | 2005-11-20 | Rhone Poulenc Agrochimie | Insecticidal method and compositions comprising 1-phenyl or 1-pyridyl 3-acetylpyrazoles, some such compunds and process for their preparation |
| US6350771B1 (en) | 1996-12-24 | 2002-02-26 | Rhone-Poulenc, Inc. | Pesticidal 1-arylpyrazoles |
| AU6826898A (en) | 1997-03-11 | 1998-09-29 | Rhone-Poulenc Agro | Pesticidal combination |
| PT976737E (pt) | 1997-04-07 | 2009-07-31 | Nihon Nohyaku Co Ltd | Derivados de pirazole, processo para a sua preparação, produtos intermédios e agente de controlo de pragas que contém como ingrediente activo um desses derivados |
| JPH10324605A (ja) | 1997-05-22 | 1998-12-08 | Nippon Nohyaku Co Ltd | 殺ダニ剤組成物及びその使用方法 |
| USD404972S (en) | 1997-06-09 | 1999-02-02 | Rodgers Jr Garnett J | Reusable dual chamber dispenser |
| US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
| US6057355A (en) | 1997-08-05 | 2000-05-02 | Rhone-Poulenc Inc. | Pesticidal combination |
| NZ501248A (en) * | 1997-08-26 | 2001-06-29 | Aventis Pharma Inc | Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
| KR100499438B1 (ko) * | 1997-12-03 | 2005-07-07 | 머크 앤드 캄파니 인코포레이티드 | 수소화 피마자유를 함유하는 지속성 주사제 |
| AUPP105597A0 (en) | 1997-12-19 | 1998-01-15 | Schering-Plough Animal Health Limited | Solvent/surfactant insecticidal pour-on formulation |
| US6090751A (en) * | 1998-06-10 | 2000-07-18 | Rhone-Poulenc Agro | Emulsifiable concentrate comprising an insecticidal 1-arylpyrazole |
| US6174540B1 (en) | 1998-09-14 | 2001-01-16 | Merck & Co., Inc. | Long acting injectable formulations containing hydrogenated caster oil |
| CO5210925A1 (es) * | 1998-11-17 | 2002-10-30 | Novartis Ag | Derivados de diamino nitroguanidina tetrasustituidos |
| US6161729A (en) | 1998-12-14 | 2000-12-19 | Unilever Home & Personal Care Usa, Division Of Conopco | Dual chamber dispenser |
| KR100715882B1 (ko) | 1998-12-18 | 2007-05-09 | 다우 글로벌 테크놀로지스 인크. | 2,3-디할로프로판올의 제조방법 |
| BR0017618B1 (pt) | 1999-03-12 | 2013-04-09 | composiÇço inseticida sinÉrgica, e, processos para controle de insetos, e para proteger plantas contra infestaÇço e ataque de insetos. | |
| WO2000073146A2 (en) | 1999-05-28 | 2000-12-07 | Sarong S.P.A. | A process and plant for manufacturing double-pouch containers |
| GB9916052D0 (en) * | 1999-07-08 | 1999-09-08 | Pfizer Ltd | Anthelmintic compositions |
| FR2800375B1 (fr) | 1999-11-03 | 2004-07-23 | Sanofi Synthelabo | Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
| MY129771A (en) | 1999-12-02 | 2007-04-30 | Merial Ltd | Control of arthropods in animals |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| PE20011289A1 (es) | 2000-04-07 | 2001-12-21 | Upjohn Co | Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles |
| US6260735B1 (en) | 2000-05-12 | 2001-07-17 | Colgate-Palmolive Company | Uniform dispensing dual chamber sachet |
| CA2311862C (en) | 2000-06-16 | 2006-10-10 | Gary O. Maupin | Control of arthropod vectors of parasitic diseases |
| CA2311881C (en) | 2000-06-16 | 2007-08-28 | Gary O. Maupin | Control of arthropods in rodents |
| IL153440A0 (en) * | 2000-07-06 | 2003-07-06 | Sumitomo Chemical Co | Insecticides |
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| NZ505779A (en) * | 2000-07-14 | 2003-06-30 | Akzo Nobel Nv | Pesticidal composition containing insect growth regulating (IGR) insecticide in an aromatic hydrocarbon and/or pyrrolidone and/or propylene glycol monoalkyl ether solvent system |
| US6399786B1 (en) | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
| EP1353662B1 (en) | 2001-01-26 | 2007-04-18 | Chugai Seiyaku Kabushiki Kaisha | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors |
| AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
| EP1465872A1 (en) | 2001-12-28 | 2004-10-13 | Bayer Pharmaceuticals Corporation | 4-sulfide/sulfoxide/sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| IL163790A0 (en) | 2002-03-05 | 2005-12-18 | Bayer Cropscience Sa | 5-Substituted-alkylaminopyrazole derivatives as pesticides |
| US7001889B2 (en) | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| AR042420A1 (es) | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
| US7345092B2 (en) * | 2002-09-12 | 2008-03-18 | Summit Vetpharm, Llc | High concentration topical insecticides containing pyrethroids |
| US7368435B2 (en) * | 2002-09-12 | 2008-05-06 | Summit Vetpharm, Llc | Topical endoparasiticide and ectoparasiticide formulations |
| US7906128B2 (en) | 2002-10-21 | 2011-03-15 | Wyeth Llc | Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals |
| WO2004049803A1 (en) | 2002-12-03 | 2004-06-17 | Bayer Cropscience S.A. | Pesticidal 5- (acylamino) pyrazole derivatives |
| ITMO20030030A1 (it) | 2003-02-07 | 2004-08-08 | Sarong Spa | Apparati e metodi per ottenere contenitori, e contenitore |
| US7262214B2 (en) | 2003-02-26 | 2007-08-28 | Merial Limited | 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases |
| US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| US6883195B1 (en) * | 2003-12-11 | 2005-04-26 | Hans P. Gustavsen | Removable rescue board patient support |
| US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| CN101768129B (zh) | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| WO2005094330A2 (en) | 2004-03-29 | 2005-10-13 | Merial Limited | Pipette/applicator |
| US20050234119A1 (en) | 2004-04-16 | 2005-10-20 | Soll Mark D | Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals |
| TWI350728B (en) | 2004-10-08 | 2011-10-21 | Wyeth Corp | Amitraz compositions |
| BRPI0518593A2 (pt) | 2004-12-07 | 2008-11-25 | Merial Ltd | derivados de 5-aminopirazol como compostos pesticidas |
| US20080003282A1 (en) | 2005-04-18 | 2008-01-03 | Soll Mark D | Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| BRPI0620668A2 (pt) | 2005-12-14 | 2011-11-22 | Du Pont | composto da fórmula 1, composição que compreende composto, composição de controle de pragas invertebradas, composição de pulverização, composição de isca, dispositivo de armadilha, métodos de controle de pragas invertebradas, método de controle de baratas, formigas ou cupins e método de proteção de sementes contra pragas invertebradas |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| MX2008016411A (es) * | 2006-07-05 | 2009-04-28 | Aventis Agriculture | Compuestos derivados de 1-aril-5-alquil pirazol, procesos para hacerlos y metodos para usarlos. |
| ITMO20060395A1 (it) | 2006-11-29 | 2008-05-30 | Sarong Spa | Contenitore, apparato e metoo per la sua produzione |
| TW200846029A (en) | 2007-02-09 | 2008-12-01 | Wyeth Corp | High dose, long-acting ectoparasiticide for extended control |
| RU2009141185A (ru) | 2007-04-10 | 2011-05-20 | Байер КропСайенс АГ (DE) | Инсектицидные производные арилизоксазолина |
| PL3088384T3 (pl) | 2007-05-15 | 2019-06-28 | Merial, Inc. | Związki aryloazol-2-ilo-cyjanoetyloaminowe, sposób ich wytwarzania oraz sposób ich stosowania |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| HUE037127T2 (hu) | 2007-06-27 | 2018-08-28 | Du Pont | Állati károkozó irtására szolgáló eljárás |
| PL2170321T3 (pl) | 2007-06-29 | 2013-12-31 | Zoetis Services Llc | Połączenie przeciwrobacze |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| SG171751A1 (en) * | 2008-11-19 | 2011-07-28 | Merial Ltd | Compositions comprising an aryl pyrazole and/ or a formamidine methods and uses thereof |
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- 2009-11-13 EP EP12189478.6A patent/EP2550962B1/en active Active
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- 2009-11-13 US US12/618,534 patent/US8450357B2/en active Active
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