BRPI0919868B8 - processo para a preparação de um derivado de clorina ou de bacterioclorina - Google Patents

processo para a preparação de um derivado de clorina ou de bacterioclorina

Info

Publication number
BRPI0919868B8
BRPI0919868B8 BRPI0919868A BRPI0919868A BRPI0919868B8 BR PI0919868 B8 BRPI0919868 B8 BR PI0919868B8 BR PI0919868 A BRPI0919868 A BR PI0919868A BR PI0919868 A BRPI0919868 A BR PI0919868A BR PI0919868 B8 BRPI0919868 B8 BR PI0919868B8
Authority
BR
Brazil
Prior art keywords
indicated
pdt
pharmaceutical compositions
methods
bacteriochlorins
Prior art date
Application number
BRPI0919868A
Other languages
English (en)
Inventor
Stochel Grazynia
Urbanska Krystyna
Guilherme Da Silva Arnaut Moreira Luís
Miguéns Pereira Maria
José Formosinho Sanches Simões Sebastião
Paulo Magalhães Simões Sérgio
Original Assignee
Bluepharma Ind Farmaceutica S A
Univ De Coimbra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluepharma Ind Farmaceutica S A, Univ De Coimbra filed Critical Bluepharma Ind Farmaceutica S A
Publication of BRPI0919868A2 publication Critical patent/BRPI0919868A2/pt
Publication of BRPI0919868B1 publication Critical patent/BRPI0919868B1/pt
Publication of BRPI0919868B8 publication Critical patent/BRPI0919868B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

processo a invenção indica os métodos de preparação, as propriedades, as composições farmacêuticas e os métodos de terapia utilizando clorinas e bacterioclorinas sulfonadas concebidas para a utilização em terapia foto dinâmica (pdt) de tecidos hiperproliferativos, tais como tumores, vasos sanguíneos hiperproliferativos e outros distúrbios ou anormalidades sensíveis à pdt. de maneira especial, descreve-se a síntese econômica em larga escala de clorinas e bacterioclorinas. as suas propriedades foram moldadas para atingirem as de fotossensibilizadores ideais em pdt. numa outra parte da patente, indicam-se as composições farmacêuticas e os métodos terapêuticos para administração sistêmica. ainda numa outra parte, indicam-se também as composições farmacêuticas e os métodos terapêuticos para administração tópica. para além disso, indica-se um método de marcação e obtenção de imagem de um tecido alvo por fluorescência e ressonância magnética.
BRPI0919868A 2008-10-24 2009-10-22 processo para a preparação de um derivado de clorina ou de bacterioclorina BRPI0919868B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0819594.3A GB0819594D0 (en) 2008-10-24 2008-10-24 Process
GB0819594.3 2008-10-24
PCT/PT2009/000057 WO2010047611A1 (en) 2008-10-24 2009-10-22 Process for preparing chlorins and their pharmaceutical uses

Publications (3)

Publication Number Publication Date
BRPI0919868A2 BRPI0919868A2 (pt) 2015-12-15
BRPI0919868B1 BRPI0919868B1 (pt) 2020-10-27
BRPI0919868B8 true BRPI0919868B8 (pt) 2021-05-25

Family

ID=40133817

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919868A BRPI0919868B8 (pt) 2008-10-24 2009-10-22 processo para a preparação de um derivado de clorina ou de bacterioclorina

Country Status (16)

Country Link
US (1) US9670217B2 (pt)
EP (1) EP2346874B1 (pt)
JP (1) JP5567024B2 (pt)
CN (1) CN102227432B (pt)
AU (1) AU2009307106B2 (pt)
BR (1) BRPI0919868B8 (pt)
CA (1) CA2741429C (pt)
DK (1) DK2346874T3 (pt)
ES (1) ES2450136T3 (pt)
GB (1) GB0819594D0 (pt)
HK (1) HK1160848A1 (pt)
PL (1) PL2346874T3 (pt)
PT (1) PT2346874E (pt)
RU (1) RU2513483C2 (pt)
WO (1) WO2010047611A1 (pt)
ZA (1) ZA201102760B (pt)

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CN103721257B (zh) * 2012-10-16 2016-12-21 无锡兆真辐射技术有限公司 光敏素催化分解过氧化氢系列药物
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AU2016238484B2 (en) 2015-03-20 2020-03-19 Luzitin, S.A. Atropisomers of halogenated tetraphenylbacteriochlorins and chlorins and their use in photodynamic therapy
CA2994822C (en) 2015-08-07 2023-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer
CA2994871A1 (en) 2015-08-18 2017-02-23 Aspyrian Therapeutics, Inc. Phthalocyanine dye conjugates and their storage
CA2994849A1 (en) 2015-08-18 2017-02-23 Aspyrian Therapeutics, Inc. Compositions, combinations and related methods for photoimmunotherapy
WO2017051435A1 (en) * 2015-09-22 2017-03-30 Council Of Scientific And Industrial Research Chlorin based compounds, a process for preparation thereof and use as photodynamic therapeutic agents and fluorescent probes
US10744212B2 (en) 2016-03-14 2020-08-18 General Electric Company Topical application of nerve labeling dyes for image-guided surgery
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WO2018216679A1 (ja) * 2017-05-22 2018-11-29 国立大学法人京都大学 テトラフェニルポルフィリン誘導体
CN111417400B (zh) * 2017-09-29 2022-12-02 杜克大学 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法
CN109912607B (zh) * 2018-12-11 2021-01-22 南华大学 一类卟啉-白杨素复合物及其抗肿瘤活性
CN109651383B (zh) * 2019-01-25 2021-11-16 华东理工大学 用于光敏剂的化合物及其应用
CA3138403A1 (en) * 2019-05-20 2020-11-26 Christopher J. MACNEVIN Narrow emission dyes, compositions comprising same, and methods for making and using same
RU2725876C1 (ru) * 2019-07-15 2020-07-07 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Производные фторсодержащих хлоринов, проявляющие противоопухолевую активность
WO2022100750A1 (zh) * 2020-11-16 2022-05-19 北京厚燊维康科技有限责任公司 可用于光动力治疗或诊断的制剂
RU2759743C2 (ru) * 2021-04-14 2021-11-17 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Способ комбинированного лечения локализованного t1-t2n0m0 рака гортани
JPWO2023022187A1 (pt) * 2021-08-18 2023-02-23
WO2023059180A1 (en) * 2021-10-06 2023-04-13 Tunku Abdul Rahman University Of Management And Technology (Tar Umt) Treating skin diseases using a photodynamic therapy (pdt) and a topical agent photosensitizer formulation
CN114813592A (zh) * 2022-03-11 2022-07-29 华南理工大学 一种探究羟基氯喹在自然水体中降解机理的方法
CN114870011B (zh) * 2022-03-24 2023-06-06 深圳大学 一种增强实体瘤内原卟啉ix蓄积的微针贴片及其制备方法

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Also Published As

Publication number Publication date
CA2741429A1 (en) 2011-04-29
CA2741429C (en) 2017-04-18
ES2450136T3 (es) 2014-03-24
CN102227432A (zh) 2011-10-26
JP2012506425A (ja) 2012-03-15
WO2010047611A1 (en) 2010-04-29
AU2009307106B2 (en) 2015-05-07
JP5567024B2 (ja) 2014-08-06
RU2011114878A (ru) 2012-11-27
EP2346874A1 (en) 2011-07-27
GB0819594D0 (en) 2008-12-03
WO2010047611A9 (en) 2010-07-22
CN102227432B (zh) 2015-04-22
US20110250143A1 (en) 2011-10-13
EP2346874B1 (en) 2013-12-04
BRPI0919868A2 (pt) 2015-12-15
BRPI0919868B1 (pt) 2020-10-27
AU2009307106A1 (en) 2010-04-29
HK1160848A1 (en) 2012-08-17
ZA201102760B (en) 2012-07-25
PT2346874E (pt) 2014-03-06
RU2513483C2 (ru) 2014-04-20
DK2346874T3 (en) 2014-03-03
PL2346874T3 (pl) 2014-05-30
US9670217B2 (en) 2017-06-06

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2745 DE 15-08-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.