BRPI0912582A2 - Método de tratar câncer utilizando um inibidor cmet e axl e um inibidor erbb - Google Patents

Método de tratar câncer utilizando um inibidor cmet e axl e um inibidor erbb

Info

Publication number
BRPI0912582A2
BRPI0912582A2 BRPI0912582-5A BRPI0912582A BRPI0912582A2 BR PI0912582 A2 BRPI0912582 A2 BR PI0912582A2 BR PI0912582 A BRPI0912582 A BR PI0912582A BR PI0912582 A2 BRPI0912582 A2 BR PI0912582A2
Authority
BR
Brazil
Prior art keywords
inhibitor
cmet
treating cancer
erbb
axl
Prior art date
Application number
BRPI0912582-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Tona M Gilmer
James G Greger
Li Liu
Hong Shi
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41257222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0912582(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of BRPI0912582A2 publication Critical patent/BRPI0912582A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BRPI0912582-5A 2008-05-05 2009-05-05 Método de tratar câncer utilizando um inibidor cmet e axl e um inibidor erbb BRPI0912582A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5032208P 2008-05-05 2008-05-05
PCT/US2009/042768 WO2009137429A1 (en) 2008-05-05 2009-05-05 Method of treating cancer using a cmet and axl inhibitor and an erbb inhibitor

Publications (1)

Publication Number Publication Date
BRPI0912582A2 true BRPI0912582A2 (pt) 2015-07-28

Family

ID=41257222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912582-5A BRPI0912582A2 (pt) 2008-05-05 2009-05-05 Método de tratar câncer utilizando um inibidor cmet e axl e um inibidor erbb

Country Status (19)

Country Link
US (3) US20090274693A1 (https=)
EP (1) EP2274304A4 (https=)
JP (1) JP2011519941A (https=)
KR (1) KR20110004462A (https=)
CN (1) CN102083824A (https=)
AR (1) AR071631A1 (https=)
AU (1) AU2009244453B2 (https=)
BR (1) BRPI0912582A2 (https=)
CA (1) CA2723699A1 (https=)
CL (1) CL2009001063A1 (https=)
EA (1) EA020779B1 (https=)
IL (1) IL209057A0 (https=)
MX (1) MX2010012101A (https=)
PE (1) PE20091832A1 (https=)
SG (1) SG190623A1 (https=)
TW (1) TW201006829A (https=)
UY (1) UY31800A (https=)
WO (1) WO2009137429A1 (https=)
ZA (1) ZA201007722B (https=)

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Also Published As

Publication number Publication date
KR20110004462A (ko) 2011-01-13
CL2009001063A1 (es) 2010-09-24
US20130142790A1 (en) 2013-06-06
EP2274304A4 (en) 2012-05-30
US20090274693A1 (en) 2009-11-05
EP2274304A1 (en) 2011-01-19
PE20091832A1 (es) 2009-12-25
TW201006829A (en) 2010-02-16
ZA201007722B (en) 2011-08-31
SG190623A1 (en) 2013-06-28
AR071631A1 (es) 2010-06-30
WO2009137429A1 (en) 2009-11-12
CN102083824A (zh) 2011-06-01
US20130150363A1 (en) 2013-06-13
IL209057A0 (en) 2011-01-31
MX2010012101A (es) 2010-11-30
EA201071268A1 (ru) 2011-06-30
JP2011519941A (ja) 2011-07-14
CA2723699A1 (en) 2009-11-12
EA020779B1 (ru) 2015-01-30
AU2009244453A1 (en) 2009-11-12
UY31800A (es) 2009-11-10
AU2009244453B2 (en) 2012-07-19

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