BRPI0911634A2 - processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas - Google Patents

processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas

Info

Publication number
BRPI0911634A2
BRPI0911634A2 BRPI0911634A BRPI0911634A BRPI0911634A2 BR PI0911634 A2 BRPI0911634 A2 BR PI0911634A2 BR PI0911634 A BRPI0911634 A BR PI0911634A BR PI0911634 A BRPI0911634 A BR PI0911634A BR PI0911634 A2 BRPI0911634 A2 BR PI0911634A2
Authority
BR
Brazil
Prior art keywords
carboxamides
pyrrol
pyrimidin
aryl
amino
Prior art date
Application number
BRPI0911634A
Other languages
English (en)
Inventor
Carlo Battistini
Ermes Vanotti
Maria Gioia Fornaretto
Matteo D Anello
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of BRPI0911634A2 publication Critical patent/BRPI0911634A2/pt
Publication of BRPI0911634B1 publication Critical patent/BRPI0911634B1/pt
Publication of BRPI0911634B8 publication Critical patent/BRPI0911634B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI0911634A 2008-04-30 2009-04-30 processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas BRPI0911634B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155501 2008-04-30
IT08155501.3 2008-04-30
PCT/EP2009/055262 WO2009133170A1 (en) 2008-04-30 2009-04-30 Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h-pyrrole-3-carboxamides

Publications (3)

Publication Number Publication Date
BRPI0911634A2 true BRPI0911634A2 (pt) 2016-06-14
BRPI0911634B1 BRPI0911634B1 (pt) 2021-05-04
BRPI0911634B8 BRPI0911634B8 (pt) 2021-05-25

Family

ID=40897697

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911634A BRPI0911634B8 (pt) 2008-04-30 2009-04-30 processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas

Country Status (15)

Country Link
US (1) US8399668B2 (pt)
EP (1) EP2285801B1 (pt)
JP (1) JP5490100B2 (pt)
KR (1) KR20110044835A (pt)
CN (1) CN102036983B (pt)
AU (1) AU2009242076B2 (pt)
BR (1) BRPI0911634B8 (pt)
CA (1) CA2723209C (pt)
EA (1) EA019036B1 (pt)
ES (1) ES2436433T3 (pt)
HK (1) HK1151794A1 (pt)
IL (1) IL208951A0 (pt)
MX (1) MX2010011456A (pt)
TW (1) TWI426074B (pt)
WO (1) WO2009133170A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010533715A (ja) 2007-07-17 2010-10-28 アムジエン・インコーポレーテツド 複素環系ｐｋｂ調節剤
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
EP2417125B1 (en) * 2009-03-27 2015-09-09 Nerviano Medical Sciences S.r.l. N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as mps1 kinase inhibitors
CN102666527B (zh) * 2009-11-04 2014-10-01 内尔维阿诺医学科学有限公司 5-(2-氨基-嘧啶-4-基)-2-芳基-1h-吡咯-3-甲酰胺的制备方法
WO2011057960A1 (en) 2009-11-11 2011-05-19 Nerviano Medical Sciences S.R.L. Crystalline cdc7 inhibitor salts
TW201127384A (en) * 2009-11-18 2011-08-16 Nerviano Medical Sciences Srl Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent
EP2699564B1 (en) * 2011-04-19 2016-12-14 Nerviano Medical Sciences S.r.l. Substituted pyrimidinyl-pyrroles active as kinase inhibitors
EP2736514B1 (en) * 2011-07-28 2017-10-18 Nerviano Medical Sciences S.r.l. Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
EP4291176A1 (en) * 2021-02-12 2023-12-20 Relay Therapeutics, Inc. Cdk inhibitors and methods of use thereof
EP4313971A1 (en) 2021-04-02 2024-02-07 Nerviano Medical Sciences S.r.l. Substituted pyrrole carboxamides, process for their preparation and their use as kinase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805280B (en) * 1979-08-27 1982-04-28 Du Pont Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h-pyrrole-2-methanols and 1-(4,5-diaryl-1h-pyrrol-2-yl)polyfluoralkanones
US5284863A (en) * 1991-12-04 1994-02-08 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
JPH06135961A (ja) * 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5559137A (en) * 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
GB0121488D0 (en) * 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
GB0229243D0 (en) * 2002-12-16 2003-01-22 Avecia Ltd Compounds and process
CA2526578C (en) * 2003-05-22 2012-01-24 Pharmacia Italia S.P.A. Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
US7470701B2 (en) * 2004-03-30 2008-12-30 Novartis Vaccines And Diagnostics, Inc. Substituted 2,5-heterocyclic derivatives
CN101103025B (zh) * 2005-03-21 2010-09-08 卫材R&D管理有限公司 5-[2-氨基-4-(2-呋喃基)嘧啶-5-基]-1-甲基吡啶-2(1h)-酮的结晶及其制备方法
TWI394749B (zh) * 2006-03-27 2013-05-01 內維亞諾醫學公司 具有激酶抑制劑活性之雜戊環

Also Published As

Publication number Publication date
AU2009242076B2 (en) 2013-10-10
CN102036983A (zh) 2011-04-27
TWI426074B (zh) 2014-02-11
CN102036983B (zh) 2014-02-19
HK1151794A1 (en) 2012-02-10
IL208951A0 (en) 2011-01-31
CA2723209A1 (en) 2009-11-05
KR20110044835A (ko) 2011-05-02
JP5490100B2 (ja) 2014-05-14
EP2285801B1 (en) 2013-10-09
TW200951124A (en) 2009-12-16
BRPI0911634B1 (pt) 2021-05-04
CA2723209C (en) 2016-06-21
ES2436433T3 (es) 2014-01-02
US20110040090A1 (en) 2011-02-17
BRPI0911634B8 (pt) 2021-05-25
EA201071252A1 (ru) 2011-06-30
WO2009133170A1 (en) 2009-11-05
MX2010011456A (es) 2010-11-30
AU2009242076A1 (en) 2009-11-05
EP2285801A1 (en) 2011-02-23
JP2011518866A (ja) 2011-06-30
US8399668B2 (en) 2013-03-19
EA019036B1 (ru) 2013-12-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE. PAGAR RESTAURACAO.

B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: NAO CONHECIDA A PETICAO NO 870160058967 DE 11/10/2016 , EM VIRTUDE DO DISPOSTO NO ARTO 219, INCISO II DA LPI.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2385 DE 20/09/2016

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/04/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF