HK1151794A1 - Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h- pyrrole-3-carboxamides 5-(2---4-)-2--1h--3- - Google Patents

Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h- pyrrole-3-carboxamides 5-(2---4-)-2--1h--3-

Info

Publication number
HK1151794A1
HK1151794A1 HK11105723.0A HK11105723A HK1151794A1 HK 1151794 A1 HK1151794 A1 HK 1151794A1 HK 11105723 A HK11105723 A HK 11105723A HK 1151794 A1 HK1151794 A1 HK 1151794A1
Authority
HK
Hong Kong
Prior art keywords
carboxamides
pyrimidin
pyrrole
aryl
amino
Prior art date
Application number
HK11105723.0A
Other languages
English (en)
Chinese (zh)
Inventor
‧迪阿尼洛
‧巴蒂斯蒂尼
‧弗納雷托
‧瓦諾蒂
Original Assignee
內爾維阿諾醫學科學有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 內爾維阿諾醫學科學有限公司 filed Critical 內爾維阿諾醫學科學有限公司
Publication of HK1151794A1 publication Critical patent/HK1151794A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK11105723.0A 2008-04-30 2011-06-07 Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h- pyrrole-3-carboxamides 5-(2---4-)-2--1h--3- HK1151794A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155501 2008-04-30
PCT/EP2009/055262 WO2009133170A1 (en) 2008-04-30 2009-04-30 Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h-pyrrole-3-carboxamides

Publications (1)

Publication Number Publication Date
HK1151794A1 true HK1151794A1 (en) 2012-02-10

Family

ID=40897697

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11105723.0A HK1151794A1 (en) 2008-04-30 2011-06-07 Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h- pyrrole-3-carboxamides 5-(2---4-)-2--1h--3-

Country Status (15)

Country Link
US (1) US8399668B2 (xx)
EP (1) EP2285801B1 (xx)
JP (1) JP5490100B2 (xx)
KR (1) KR20110044835A (xx)
CN (1) CN102036983B (xx)
AU (1) AU2009242076B2 (xx)
BR (1) BRPI0911634B8 (xx)
CA (1) CA2723209C (xx)
EA (1) EA019036B1 (xx)
ES (1) ES2436433T3 (xx)
HK (1) HK1151794A1 (xx)
IL (1) IL208951A0 (xx)
MX (1) MX2010011456A (xx)
TW (1) TWI426074B (xx)
WO (1) WO2009133170A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
ES2552282T3 (es) * 2009-03-27 2015-11-26 Nerviano Medical Sciences S.R.L. Derivados de N-aril-2-(2-arilaminopirimidin-4-il)pirrol-4-carboxamida como inhibidores de la cinasa MPS1
EA021299B1 (ru) 2009-11-04 2015-05-29 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Способ получения 5-(2-аминопиримидин-4-ил)-2-арил-1н-пиррол-3-карбоксамидов
CN102666528B (zh) * 2009-11-11 2014-04-16 内尔维阿诺医学科学有限公司 晶体cdc7 抑制剂盐
TW201127384A (en) * 2009-11-18 2011-08-16 Nerviano Medical Sciences Srl Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent
BR112013026137B1 (pt) * 2011-04-19 2020-12-01 Nerviano Medical Sciences S.R.L pirimidinil-pirróis substituídos ativos como inibidores da quinase
US8912200B2 (en) 2011-07-28 2014-12-16 Nerviano Medical Sciences S.R.L. Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
MX2023009086A (es) * 2021-02-12 2023-08-08 Relay Therapeutics Inc Inhibidores de cinasas dependientes de ciclinas (cdk) y metodos de uso de estos.
WO2022207404A1 (en) 2021-04-02 2022-10-06 Nerviano Medical Sciences S.R.L. Substituted pyrrole carboxamides, process for their preparation and their use as kinase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805280B (en) * 1979-08-27 1982-04-28 Du Pont Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h-pyrrole-2-methanols and 1-(4,5-diaryl-1h-pyrrol-2-yl)polyfluoralkanones
US5284863A (en) * 1991-12-04 1994-02-08 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
JPH06135961A (ja) * 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5559137A (en) * 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
GB0121488D0 (en) * 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
GB0229243D0 (en) * 2002-12-16 2003-01-22 Avecia Ltd Compounds and process
CN1826343A (zh) * 2003-05-22 2006-08-30 法玛西雅意大利公司 吡唑并－喹唑啉衍生物、它们的制备方法和它们作为激酶抑制剂的用途
AU2005228899A1 (en) * 2004-03-30 2005-10-13 Novartis Vaccines And Diagnostics, Inc. Substituted thiophene derivatives as anti-cancer agents
WO2006101082A1 (ja) * 2005-03-21 2006-09-28 Eisai R & D Management Co., Ltd. ピリミジン化合物の結晶、非晶質および製造方法
NZ572202A (en) * 2006-03-27 2012-05-25 Nerviano Medical Sciences Srl Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors

Also Published As

Publication number Publication date
BRPI0911634B1 (pt) 2021-05-04
EP2285801B1 (en) 2013-10-09
MX2010011456A (es) 2010-11-30
US8399668B2 (en) 2013-03-19
EA019036B1 (ru) 2013-12-30
CN102036983A (zh) 2011-04-27
CN102036983B (zh) 2014-02-19
JP2011518866A (ja) 2011-06-30
TWI426074B (zh) 2014-02-11
TW200951124A (en) 2009-12-16
AU2009242076A1 (en) 2009-11-05
IL208951A0 (en) 2011-01-31
AU2009242076B2 (en) 2013-10-10
CA2723209A1 (en) 2009-11-05
EA201071252A1 (ru) 2011-06-30
BRPI0911634A2 (pt) 2016-06-14
JP5490100B2 (ja) 2014-05-14
US20110040090A1 (en) 2011-02-17
EP2285801A1 (en) 2011-02-23
BRPI0911634B8 (pt) 2021-05-25
ES2436433T3 (es) 2014-01-02
KR20110044835A (ko) 2011-05-02
CA2723209C (en) 2016-06-21
WO2009133170A1 (en) 2009-11-05

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