BRPI0908120A2 - - Google Patents

Info

Publication number
BRPI0908120A2
BRPI0908120A2 BRPI0908120A BRPI0908120A2 BR PI0908120 A2 BRPI0908120 A2 BR PI0908120A2 BR PI0908120 A BRPI0908120 A BR PI0908120A BR PI0908120 A2 BRPI0908120 A2 BR PI0908120A2
Authority
BR
Brazil
Application number
Other languages
Portuguese (pt)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0908120(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of BRPI0908120A2 publication Critical patent/BRPI0908120A2/pt
Publication of BRPI0908120A8 publication Critical patent/BRPI0908120A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0908120A 2008-02-21 2009-02-19 Compostos que são inibidores de erk, composição faramacêutica e uso BRPI0908120A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21
PCT/US2009/034447 WO2009105500A1 (en) 2008-02-21 2009-02-19 Compounds that are erk inhibitors

Publications (2)

Publication Number Publication Date
BRPI0908120A2 true BRPI0908120A2 (enEXAMPLES) 2017-08-22
BRPI0908120A8 BRPI0908120A8 (pt) 2017-10-24

Family

ID=40601237

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908120A BRPI0908120A8 (pt) 2008-02-21 2009-02-19 Compostos que são inibidores de erk, composição faramacêutica e uso

Country Status (23)

Country Link
US (1) US8716483B2 (enEXAMPLES)
EP (1) EP2260031B1 (enEXAMPLES)
JP (1) JP5276676B2 (enEXAMPLES)
KR (1) KR20100117123A (enEXAMPLES)
CN (1) CN102015693B (enEXAMPLES)
AR (1) AR070460A1 (enEXAMPLES)
AU (1) AU2009215534B8 (enEXAMPLES)
BR (1) BRPI0908120A8 (enEXAMPLES)
CA (1) CA2714479A1 (enEXAMPLES)
CL (1) CL2009000394A1 (enEXAMPLES)
CO (1) CO6300939A2 (enEXAMPLES)
EC (1) ECSP10010415A (enEXAMPLES)
ES (1) ES2556353T3 (enEXAMPLES)
IL (1) IL207530A (enEXAMPLES)
MX (1) MX2010009268A (enEXAMPLES)
MY (1) MY152271A (enEXAMPLES)
NZ (1) NZ587504A (enEXAMPLES)
PE (1) PE20091491A1 (enEXAMPLES)
RU (1) RU2525389C2 (enEXAMPLES)
SG (1) SG188179A1 (enEXAMPLES)
TW (1) TWI398441B (enEXAMPLES)
WO (1) WO2009105500A1 (enEXAMPLES)
ZA (2) ZA201005909B (enEXAMPLES)

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US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
WO2007097937A1 (en) 2006-02-16 2007-08-30 Schering Corporation Pyrrolidine derivatives as erk inhibitors
US9229008B2 (en) 2008-08-19 2016-01-05 Merck Sharp & Dohme Corp. IL-8 level as a determinant of responsivity of a cancer to treatment
WO2010021978A2 (en) * 2008-08-19 2010-02-25 Schering Corporation Il-8 biomarker
US8609675B2 (en) 2009-07-02 2013-12-17 Merck Sharp & Dohme Corp. Fused Tricyclic Compounds as novel mTOR inhibitors
US8658651B2 (en) 2009-09-30 2014-02-25 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
WO2011163330A1 (en) * 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
BR112013009823A2 (pt) 2010-10-22 2016-07-05 Bayer Ip Gmbh novos compostos heterocíclicos como pesticidas
JP2014500874A (ja) * 2010-11-16 2014-01-16 メディミューン，エルエルシー 抗ｉｇｆ抗体を用いた治療レジメン
WO2013015918A1 (en) 2011-07-22 2013-01-31 Iowa State University Research Foundation, Inc. Method of regioselective synthesis of substituted benzoates
AR090220A1 (es) 2012-03-01 2014-10-29 Array Biopharma Inc Inhibidores de serina/treonina cinasa
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
MX2015000830A (es) * 2012-07-18 2015-10-26 Sunshine Lake Pharma Co Ltd Derivados heterociclicos nitrogenosos y su aplicacion en farmacos.
US9226922B2 (en) 2012-09-28 2016-01-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
AU2013323508B2 (en) 2012-09-28 2017-11-02 Merck Sharp & Dohme Corp. Novel compounds that are ERK inhibitors
BR112015020716A2 (pt) * 2013-03-13 2017-07-18 Hoffmann La Roche processo para a preparação de (2-(4-(2-(1-isopropil-3-metil-1h-1,2,4-triazol-5-il)-5,6-diidrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-il)-1h-pirazol-1-il)-2-metilpropanamida (i) e composto
US8871966B2 (en) 2013-03-15 2014-10-28 Iowa State University Research Foundation, Inc. Regiospecific synthesis of terephthalates
SMT201800205T1 (it) 2013-10-03 2018-05-02 Kura Oncology Inc Inibitori di erk e metodi d'uso
EP3143166A4 (en) 2014-05-16 2018-04-18 University of Massachusetts Treating chronic myelogenous leukemia (cml)
WO2016025639A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Combinations of an erk inhibitor and a chemotherapeutic agent and related methods
WO2016095088A1 (en) * 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
WO2016095089A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
CN111662272A (zh) * 2014-12-18 2020-09-15 默沙东公司 用于药物制剂的化合物
RU2712148C2 (ru) * 2014-12-19 2020-01-24 Мерк Шарп И Доум Корп. (s)-n-(3-(6-изопропоксипиридин-3-ил)-1h-индазол-5-ил)-1-(2-(4-(4-(1-метил-1h-1,2,4-триазол-3-ил)фенил)-3,6-дигидропиридин-1(2н)-ил)-2-оксоэтил)-3-(метилтио)пирролидин-3-карбоксамидные композиции для фармацевтических препаратов
HUE049481T2 (hu) * 2015-04-03 2020-09-28 Recurium Ip Holdings Llc Spirociklusos vegyületek
US20180250232A1 (en) * 2015-09-03 2018-09-06 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
WO2021067266A1 (en) * 2019-10-01 2021-04-08 Recurium Ip Holdings, Llc Pyrrolidinyl-based compounds
CN114867529B (zh) 2019-10-09 2024-09-27 拜耳公司 作为农药的新的杂芳基三唑化合物
TWI765451B (zh) 2019-12-06 2022-05-21 大陸商南京明德新藥研發有限公司 作為erk抑制劑的螺環類化合物及其應用

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Also Published As

Publication number Publication date
AU2009215534A1 (en) 2009-08-27
SG188179A1 (en) 2013-03-28
AU2009215534B8 (en) 2014-07-10
RU2010138635A (ru) 2012-03-27
EP2260031B1 (en) 2015-10-07
CL2009000394A1 (es) 2011-02-11
US20110189192A1 (en) 2011-08-04
NZ587504A (en) 2012-09-28
WO2009105500A1 (en) 2009-08-27
TWI398441B (zh) 2013-06-11
AU2009215534B2 (en) 2014-06-26
ZA201005909B (en) 2014-03-26
JP5276676B2 (ja) 2013-08-28
EP2260031A1 (en) 2010-12-15
KR20100117123A (ko) 2010-11-02
PE20091491A1 (es) 2009-09-25
AR070460A1 (es) 2010-04-07
TW200948799A (en) 2009-12-01
BRPI0908120A8 (pt) 2017-10-24
ES2556353T3 (es) 2016-01-15
IL207530A0 (en) 2010-12-30
IL207530A (en) 2014-08-31
CA2714479A1 (en) 2009-08-27
CN102015693B (zh) 2014-10-29
CN102015693A (zh) 2011-04-13
ZA201400396B (en) 2014-12-23
RU2525389C2 (ru) 2014-08-10
ES2556353T8 (es) 2017-10-13
AU2009215534A8 (en) 2014-07-10
AU2009215534A2 (en) 2010-12-23
MY152271A (en) 2014-09-15
US8716483B2 (en) 2014-05-06
ECSP10010415A (es) 2010-09-30
MX2010009268A (es) 2010-09-14
JP2011513225A (ja) 2011-04-28
CO6300939A2 (es) 2011-07-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]