BRPI0821855A2 - Composto, agente farmacêutico, uso de um composto inibidor de dna girase bacteriana, agente antibacteriano, e, agente terapêutico para doença infecciosa - Google Patents
Composto, agente farmacêutico, uso de um composto inibidor de dna girase bacteriana, agente antibacteriano, e, agente terapêutico para doença infecciosaInfo
- Publication number
- BRPI0821855A2 BRPI0821855A2 BRPI0821855-2A BRPI0821855A BRPI0821855A2 BR PI0821855 A2 BRPI0821855 A2 BR PI0821855A2 BR PI0821855 A BRPI0821855 A BR PI0821855A BR PI0821855 A2 BRPI0821855 A2 BR PI0821855A2
- Authority
- BR
- Brazil
- Prior art keywords
- agent
- compound
- infectious disease
- bacterial dna
- dna gyrase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 108020000946 Bacterial DNA Proteins 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000002271 gyrase inhibitor Substances 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007337693 | 2007-12-27 | ||
JP2007-337693 | 2007-12-27 | ||
PCT/JP2008/073686 WO2009084614A1 (ja) | 2007-12-27 | 2008-12-26 | イミダゾールカルボニル化合物 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0821855A2 true BRPI0821855A2 (pt) | 2015-06-16 |
BRPI0821855B1 BRPI0821855B1 (pt) | 2019-08-27 |
BRPI0821855B8 BRPI0821855B8 (pt) | 2021-05-25 |
Family
ID=40824327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0821855A BRPI0821855B8 (pt) | 2007-12-27 | 2008-12-26 | composto, composição farmacêutica, e, uso de um composto ou sal farmaceuticamente aceitável do mesmo |
Country Status (11)
Country | Link |
---|---|
US (2) | US8536197B2 (pt) |
EP (1) | EP2226322B1 (pt) |
JP (2) | JP5586234B2 (pt) |
KR (1) | KR101578954B1 (pt) |
CN (1) | CN101959882B (pt) |
BR (1) | BRPI0821855B8 (pt) |
CA (1) | CA2710959C (pt) |
ES (1) | ES2535085T3 (pt) |
HK (1) | HK1147259A1 (pt) |
TW (1) | TWI498115B (pt) |
WO (1) | WO2009084614A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI498115B (zh) | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
GB2498080A (en) * | 2011-12-21 | 2013-07-03 | Redx Pharma Ltd | Derivatives of oseltamivir |
US9034874B2 (en) * | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
CN104016925B (zh) * | 2014-06-17 | 2016-03-30 | 遵义医学院 | 4-烷基咪唑-2-羧酸的合成方法 |
CN104059020B (zh) * | 2014-06-27 | 2016-08-31 | 湖南海利常德农药化工有限公司 | 1-芳基-5-羟基吡唑的制备方法 |
KR20180022826A (ko) | 2015-07-02 | 2018-03-06 | 얀센 사이언시즈 아일랜드 유씨 | 항균 화합물 |
CN108137574B (zh) * | 2015-09-30 | 2021-12-28 | 第一三共株式会社 | 羟烷基噻二唑衍生物 |
WO2017216281A1 (en) | 2016-06-16 | 2017-12-21 | Janssen Sciences Ireland Uc | Heterocyclic compounds as antibacterials |
CN110831630A (zh) | 2017-03-01 | 2020-02-21 | 爱尔兰詹森科学公司 | 组合疗法 |
JP2020511457A (ja) * | 2017-03-14 | 2020-04-16 | 第一三共株式会社 | ヒドロキシアルキルチアジアゾール誘導体のn−ホスホノキシメチルプロドラッグ |
JPWO2018174288A1 (ja) | 2017-03-24 | 2020-01-23 | 大正製薬株式会社 | 2(1h)−キノリノン誘導体 |
US20210323957A1 (en) | 2018-09-03 | 2021-10-21 | Univerza V Ljubljani | New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria |
CN113045564A (zh) * | 2019-12-27 | 2021-06-29 | 上海天慈国际药业有限公司 | 一种阿培利司的制备方法 |
CN111592495A (zh) * | 2020-07-06 | 2020-08-28 | 上海启讯医药科技有限公司 | 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法 |
CN115989225A (zh) * | 2020-08-31 | 2023-04-18 | 豪夫迈·罗氏有限公司 | 作为抗菌药物的咪唑-吡唑衍生物 |
CN115989227A (zh) * | 2020-09-01 | 2023-04-18 | 豪夫迈·罗氏有限公司 | 具有抗菌性的咪唑-吡唑衍生物 |
WO2022129327A1 (en) | 2020-12-17 | 2022-06-23 | Univerza V Ljubljani | New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity |
CN114436991A (zh) * | 2021-12-25 | 2022-05-06 | 上海泰坦科技股份有限公司 | 一种2-氨基噻唑类化合物的合成方法 |
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TWI498115B (zh) | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
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2008
- 2008-12-25 TW TW097150632A patent/TWI498115B/zh active
- 2008-12-26 EP EP08867971.7A patent/EP2226322B1/en active Active
- 2008-12-26 CA CA2710959A patent/CA2710959C/en active Active
- 2008-12-26 KR KR1020107013997A patent/KR101578954B1/ko active IP Right Grant
- 2008-12-26 WO PCT/JP2008/073686 patent/WO2009084614A1/ja active Application Filing
- 2008-12-26 CN CN2008801277565A patent/CN101959882B/zh active Active
- 2008-12-26 JP JP2009548077A patent/JP5586234B2/ja active Active
- 2008-12-26 US US12/811,004 patent/US8536197B2/en active Active
- 2008-12-26 BR BRPI0821855A patent/BRPI0821855B8/pt not_active IP Right Cessation
- 2008-12-26 ES ES08867971.7T patent/ES2535085T3/es active Active
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2011
- 2011-02-16 HK HK11101476.8A patent/HK1147259A1/xx unknown
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2013
- 2013-09-13 US US14/027,077 patent/US8927588B2/en active Active
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2014
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TWI498115B (zh) | 2015-09-01 |
JP2014196369A (ja) | 2014-10-16 |
US8927588B2 (en) | 2015-01-06 |
EP2226322B1 (en) | 2015-01-21 |
KR20100098657A (ko) | 2010-09-08 |
JP5586234B2 (ja) | 2014-09-10 |
BRPI0821855B1 (pt) | 2019-08-27 |
KR101578954B1 (ko) | 2015-12-18 |
JPWO2009084614A1 (ja) | 2011-05-19 |
CN101959882A (zh) | 2011-01-26 |
ES2535085T3 (es) | 2015-05-05 |
CA2710959A1 (en) | 2009-07-09 |
US20100311966A1 (en) | 2010-12-09 |
EP2226322A4 (en) | 2011-06-08 |
WO2009084614A1 (ja) | 2009-07-09 |
JP5798221B2 (ja) | 2015-10-21 |
BRPI0821855B8 (pt) | 2021-05-25 |
HK1147259A1 (en) | 2011-08-05 |
US8536197B2 (en) | 2013-09-17 |
CN101959882B (zh) | 2013-09-11 |
US20140073622A1 (en) | 2014-03-13 |
TW200932221A (en) | 2009-08-01 |
EP2226322A1 (en) | 2010-09-08 |
CA2710959C (en) | 2013-10-01 |
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