BRPI0808772A2 - Inibidores da via de hedgehog - Google Patents

Inibidores da via de hedgehog Download PDF

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Publication number
BRPI0808772A2
BRPI0808772A2 BRPI0808772-5A BRPI0808772A BRPI0808772A2 BR PI0808772 A2 BRPI0808772 A2 BR PI0808772A2 BR PI0808772 A BRPI0808772 A BR PI0808772A BR PI0808772 A2 BRPI0808772 A2 BR PI0808772A2
Authority
BR
Brazil
Prior art keywords
amino
benzamido
methyl
phenyl
compound
Prior art date
Application number
BRPI0808772-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Suley-Man Bahceci
William Bajjalieh
Jeff Chen
Sergey Epshteyn
Timothy Patrick Forsyth
Tai Phat Huynh
Byung Gyu Kim
James W Leahy
Matthew Sangyup Lee
Gary L Lewis
Morrison B Mac
Grace Mann
Charles K Marlowe
Brian Hugh Ridgway
Joan C Sangalang
Xian Shi
Craig Stacy Takeuchi
Zerom Tesfai
Yong Wang
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of BRPI0808772A2 publication Critical patent/BRPI0808772A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0808772-5A 2007-03-14 2008-03-13 Inibidores da via de hedgehog BRPI0808772A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91816007P 2007-03-14 2007-03-14
US60/918,160 2007-03-14
US96261707P 2007-07-30 2007-07-30
US60/962,617 2007-07-30
PCT/US2008/056883 WO2008112913A1 (en) 2007-03-14 2008-03-13 Inhibitors of the hedgehog pathway

Publications (1)

Publication Number Publication Date
BRPI0808772A2 true BRPI0808772A2 (pt) 2014-08-12

Family

ID=39760053

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808772-5A BRPI0808772A2 (pt) 2007-03-14 2008-03-13 Inibidores da via de hedgehog

Country Status (18)

Country Link
US (3) US8222263B2 (https=)
EP (2) EP2134695A4 (https=)
JP (1) JP5577104B2 (https=)
KR (1) KR20090130051A (https=)
CN (1) CN101679308B (https=)
AR (1) AR065767A1 (https=)
AU (1) AU2008224941C1 (https=)
BR (1) BRPI0808772A2 (https=)
CA (1) CA2680796A1 (https=)
CO (1) CO6231031A2 (https=)
EA (1) EA018441B1 (https=)
GE (1) GEP20135925B (https=)
IL (1) IL200603A (https=)
MX (1) MX2009009786A (https=)
NZ (2) NZ579480A (https=)
SG (1) SG179418A1 (https=)
TW (1) TWI430798B (https=)
WO (1) WO2008112913A1 (https=)

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JP2009542818A (ja) * 2006-06-16 2009-12-03 グラクソ グループ リミテッド 新規化合物
CN101679308B (zh) 2007-03-14 2014-05-07 埃克塞里艾克西斯公司 Hedgehog途径抑制剂

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CN101679308A (zh) 2010-03-24
EP2134695A4 (en) 2011-05-25
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MX2009009786A (es) 2009-09-24
TW200843777A (en) 2008-11-16
IL200603A (en) 2014-08-31
WO2008112913A1 (en) 2008-09-18
NZ579480A (en) 2012-03-30
JP5577104B2 (ja) 2014-08-20
EA200970856A1 (ru) 2010-04-30
US8796294B2 (en) 2014-08-05
SG179418A1 (en) 2012-04-27
EP2527330A1 (en) 2012-11-28
CA2680796A1 (en) 2008-09-18
AU2008224941B2 (en) 2012-12-20
NZ598251A (en) 2013-06-28
TWI430798B (zh) 2014-03-21
CN101679308B (zh) 2014-05-07
US8222263B2 (en) 2012-07-17
AU2008224941A1 (en) 2008-09-18
CO6231031A2 (es) 2010-12-20
JP2010521487A (ja) 2010-06-24
US20120238570A1 (en) 2012-09-20
US20090105211A1 (en) 2009-04-23
US20120245139A1 (en) 2012-09-27
US8754092B2 (en) 2014-06-17
KR20090130051A (ko) 2009-12-17
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EP2134695A1 (en) 2009-12-23
AU2008224941C1 (en) 2013-06-27

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