BRPI0719280A2 - Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. - Google Patents
Composto, composição farmacêutica, métodos para modular a atividade de um receptor de p2x7 in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor de p2x7 em um paciente, para inibir a morte de células do gânglio retinal em um paciente, para determinar a presença ou ausência de receptor de p2x7 em uma amostra, preparação farmacêutica acondicionada, método para tratar ou prevenir cirrose em um paciente, e, uso de um composto. Download PDFInfo
- Publication number
- BRPI0719280A2 BRPI0719280A2 BRPI0719280-0A BRPI0719280A BRPI0719280A2 BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2 BR PI0719280 A BRPI0719280 A BR PI0719280A BR PI0719280 A2 BRPI0719280 A2 BR PI0719280A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- amino
- mono
- formula
- membered
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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| CN103687860B (zh) | 2011-07-22 | 2016-06-08 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的杂环酰胺衍生物 |
| BR112014017735B1 (pt) | 2012-01-20 | 2022-06-28 | Idorsia Pharmaceuticals Ltd | Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto |
| JP6295269B2 (ja) | 2012-12-12 | 2018-03-14 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｐ２ｘ７受容体アンタゴニストとしてのインドールカルボキサミド誘導体 |
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| ES2616114T3 (es) | 2013-01-22 | 2017-06-09 | Actelion Pharmaceuticals Ltd. | Derivados de amida heterocíclica como antagonistas del receptor P2X7 |
| HUE045701T2 (hu) | 2013-03-13 | 2020-01-28 | Forma Therapeutics Inc | 2-Hidroxi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etán-1-on származékok és rokon vegyületek mint zsírsav szintáz (FASN) inhibitorok, rák kezelésére |
| ES2905399T3 (es) | 2015-04-24 | 2022-04-08 | Shionogi & Co | Derivados heterocíclicos de seis miembros y composición farmacéutica que los comprende |
| CN108290894A (zh) * | 2015-07-01 | 2018-07-17 | 西北大学 | 被取代的4-甲基-吡咯并[1,2-a]嘧啶-8-甲酰胺类化合物及其调节葡糖脑苷脂酶活性的用途 |
| US10723705B2 (en) * | 2015-08-14 | 2020-07-28 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| JP7038460B2 (ja) * | 2016-10-17 | 2022-03-18 | 塩野義製薬株式会社 | 二環性含窒素複素環誘導体およびそれらを含有する医薬組成物 |
| CN111108105B (zh) | 2017-09-22 | 2023-03-31 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的杂环化合物 |
| PL3697785T3 (pl) | 2017-10-18 | 2023-08-07 | Jubilant Epipad LLC | Związki imidazopirydynowe jako inhibitory pad |
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| JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
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| BR112021000257A2 (pt) | 2018-07-09 | 2021-04-06 | Boehringer Ingelheim Animal Health USA Inc. | Compostos heterocíclicos anti-helmínticos |
| KR102812440B1 (ko) * | 2018-09-10 | 2025-05-26 | 가껭세이야꾸가부시기가이샤 | 신규한 헤테로방향족 아미드 유도체 및 이를 함유하는 약제 |
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2007
- 2007-11-27 MX MX2009005478A patent/MX2009005478A/es active IP Right Grant
- 2007-11-27 ZA ZA200904477A patent/ZA200904477B/xx unknown
- 2007-11-27 JP JP2009538419A patent/JP2010510987A/ja active Pending
- 2007-11-27 NZ NZ577814A patent/NZ577814A/en not_active IP Right Cessation
- 2007-11-27 US US12/516,480 patent/US8431593B2/en not_active Expired - Fee Related
- 2007-11-27 CN CN200780049692A patent/CN101621931A/zh active Pending
- 2007-11-27 EP EP07862234.7A patent/EP2096923B1/en active Active
- 2007-11-27 BR BRPI0719280-0A patent/BRPI0719280A2/pt not_active IP Right Cessation
- 2007-11-27 WO PCT/US2007/024396 patent/WO2008066789A2/en not_active Ceased
- 2007-11-27 CA CA002670636A patent/CA2670636A1/en not_active Abandoned
- 2007-11-27 UA UAA200906538A patent/UA99448C2/ru unknown
- 2007-11-27 MY MYPI20092150 patent/MY150731A/en unknown
- 2007-11-27 EA EA200970516A patent/EA018036B1/ru not_active IP Right Cessation
- 2007-11-27 EA EA201300152A patent/EA201300152A1/ru unknown
- 2007-11-27 KR KR1020097013490A patent/KR20090094336A/ko not_active Ceased
- 2007-11-27 AU AU2007325780A patent/AU2007325780B9/en not_active Ceased
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- 2009-06-26 NO NO20092444A patent/NO20092444L/no not_active Application Discontinuation
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2013
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Also Published As
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|---|---|
| AU2007325780B9 (en) | 2013-09-12 |
| US8431593B2 (en) | 2013-04-30 |
| CO6190582A2 (es) | 2010-08-19 |
| EP2591675A1 (en) | 2013-05-15 |
| EA018036B1 (ru) | 2013-05-30 |
| EA201300152A1 (ru) | 2013-07-30 |
| US20130172549A1 (en) | 2013-07-04 |
| EP2096923A4 (en) | 2011-01-12 |
| ZA200904477B (en) | 2010-09-29 |
| WO2008066789A2 (en) | 2008-06-05 |
| JP2010510987A (ja) | 2010-04-08 |
| MY150731A (en) | 2014-02-28 |
| NO20092444L (no) | 2009-08-27 |
| KR20090094336A (ko) | 2009-09-04 |
| IL198827A0 (en) | 2010-02-17 |
| CN101621931A (zh) | 2010-01-06 |
| AU2007325780A1 (en) | 2008-06-05 |
| UA99448C2 (en) | 2012-08-27 |
| EP2096923A2 (en) | 2009-09-09 |
| CA2670636A1 (en) | 2008-06-05 |
| NZ577814A (en) | 2012-03-30 |
| US20100216763A1 (en) | 2010-08-26 |
| EA200970516A1 (ru) | 2009-12-30 |
| EP2096923B1 (en) | 2014-01-22 |
| WO2008066789A3 (en) | 2008-08-21 |
| MX2009005478A (es) | 2009-08-12 |
| AU2007325780B2 (en) | 2013-05-02 |
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