BRPI0718480B8 - processo para a preparação de pradofloxacina - Google Patents

processo para a preparação de pradofloxacina

Info

Publication number
BRPI0718480B8
BRPI0718480B8 BRPI0718480A BRPI0718480A BRPI0718480B8 BR PI0718480 B8 BRPI0718480 B8 BR PI0718480B8 BR PI0718480 A BRPI0718480 A BR PI0718480A BR PI0718480 A BRPI0718480 A BR PI0718480A BR PI0718480 B8 BRPI0718480 B8 BR PI0718480B8
Authority
BR
Brazil
Prior art keywords
pradofloxacin
preparing
preparation
pyrrolidone
substituent
Prior art date
Application number
BRPI0718480A
Other languages
English (en)
Inventor
Adam Thomas
Wischnat Ralf
Weidemann Klaus
Original Assignee
Bayer Animal Health Gmbh
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh, Bayer Ip Gmbh filed Critical Bayer Animal Health Gmbh
Publication of BRPI0718480A2 publication Critical patent/BRPI0718480A2/pt
Publication of BRPI0718480B1 publication Critical patent/BRPI0718480B1/pt
Publication of BRPI0718480B8 publication Critical patent/BRPI0718480B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA A PREPARAÇÃO DE PRADOFLOXACINA. A presente invenção refere-se a um processo aperfeiçoado para a preparação de pradofloxacina, no qual o substituinte na posição 7 é introduzido por substituição nucleofílica em uma mistura de solventes de N-metil-pirrolidona - etanol.
BRPI0718480A 2006-10-20 2007-10-06 processo para a preparação de pradofloxacina BRPI0718480B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006049520.9 2006-10-20
DE102006049520A DE102006049520A1 (de) 2006-10-20 2006-10-20 Verfahren zur Herstellung von Pradofloxacin
PCT/EP2007/008687 WO2008046532A1 (de) 2006-10-20 2007-10-06 Verfahren zur herstellung von pradofloxacin

Publications (3)

Publication Number Publication Date
BRPI0718480A2 BRPI0718480A2 (pt) 2014-02-18
BRPI0718480B1 BRPI0718480B1 (pt) 2021-04-13
BRPI0718480B8 true BRPI0718480B8 (pt) 2022-09-20

Family

ID=38982832

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718480A BRPI0718480B8 (pt) 2006-10-20 2007-10-06 processo para a preparação de pradofloxacina

Country Status (22)

Country Link
US (1) US8497377B2 (pt)
EP (1) EP2086976B1 (pt)
JP (2) JP5830221B2 (pt)
AR (1) AR063227A1 (pt)
AT (1) ATE509930T1 (pt)
AU (1) AU2007312599B2 (pt)
BR (1) BRPI0718480B8 (pt)
CA (1) CA2666932C (pt)
CL (1) CL2007003007A1 (pt)
DE (1) DE102006049520A1 (pt)
DK (1) DK2086976T3 (pt)
ES (1) ES2365637T3 (pt)
MX (1) MX2009003200A (pt)
NZ (1) NZ576333A (pt)
PE (1) PE20081466A1 (pt)
PL (1) PL2086976T3 (pt)
PT (1) PT2086976E (pt)
SI (1) SI2086976T1 (pt)
TW (1) TW200823210A (pt)
UY (1) UY30646A1 (pt)
WO (1) WO2008046532A1 (pt)
ZA (1) ZA200902530B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT882049E (pt) 1996-02-23 2003-04-30 Bayer Ag Acidos 8-ciano-1-ciclopropil-7-(2,8-diazabiciclo-¬4.3.0|nonan-8-il)-6-fluoro-1,4-dihidro-4-oxo-quinolino-carboxilicos eventualmente substituidos e seus derivados
DE19717231A1 (de) 1997-04-24 1998-10-29 Bayer Ag 3-Cyano-2,4,5-trifluor-benzoylfluorid
DE19733243A1 (de) * 1997-08-01 1999-02-04 Bayer Ag Verfahren zur Herstellung von 3-Cyano-2,4-dihalogen-5-fluor-benzoesäure
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE10134719A1 (de) 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
DE10224086A1 (de) 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10337191A1 (de) 2003-08-13 2005-03-17 Bayer Healthcare Ag Neue Verwendung von Chinolon-Antibiotika
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin

Also Published As

Publication number Publication date
PT2086976E (pt) 2011-07-27
CA2666932C (en) 2015-03-10
AU2007312599A1 (en) 2008-04-24
BRPI0718480B1 (pt) 2021-04-13
DE102006049520A1 (de) 2008-04-24
ATE509930T1 (de) 2011-06-15
WO2008046532A1 (de) 2008-04-24
ZA200902530B (en) 2010-07-28
CA2666932A1 (en) 2008-04-24
JP5830221B2 (ja) 2015-12-09
EP2086976A1 (de) 2009-08-12
PL2086976T3 (pl) 2011-10-31
DK2086976T3 (da) 2011-09-05
ES2365637T3 (es) 2011-10-07
US20090318700A1 (en) 2009-12-24
JP2010506865A (ja) 2010-03-04
BRPI0718480A2 (pt) 2014-02-18
EP2086976B1 (de) 2011-05-18
NZ576333A (en) 2011-12-22
AR063227A1 (es) 2009-01-14
AU2007312599B2 (en) 2013-11-14
MX2009003200A (es) 2009-04-07
SI2086976T1 (sl) 2011-09-30
US8497377B2 (en) 2013-07-30
UY30646A1 (es) 2008-05-31
JP2016028055A (ja) 2016-02-25
TW200823210A (en) 2008-06-01
PE20081466A1 (es) 2008-12-18
CL2007003007A1 (es) 2008-04-04

Similar Documents

Publication Publication Date Title
BRPI0813284A8 (pt) Processo para a preparação de um composto da fórmula (i) e composto
BR112015021240A2 (pt) processo para sal de sódio de (2s, 5r)-2-carboxamido-7-oxo-6-sulfo-oxi-1,6-diaza-biciclo[3.2.1]octano
BRPI0607455A2 (pt) composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
BRPI0520870B8 (pt) compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila
EA200870423A1 (ru) Производные триазолпиразинов, применимые в качестве противораковых агентов
ECSP088854A (es) Moduladores bencimidazolicos de vr1
NO20084278L (no) Bezothiazol derivatives as beta2 adrenoreceptor agonists
ECSP088623A (es) Derivados de azepinoindol como agentes farmacéuticos
BRPI0712631B8 (pt) compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações
BRPI0618482A2 (pt) nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma
BR112015009395A2 (pt) processo para preparação de derivados do ácido biliar
EA201001205A1 (ru) Соединения, содержащие циклобутоксигруппу
BRPI0607309A2 (pt) processos para a preparação de fenilpirazol uréias substituìdas
WO2010121576A3 (en) Novel 7-deazapurine nucleosides for therapeutic uses
UY29360A1 (es) Nuevos derivados de pirazol, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones.
ATE523514T1 (de) Tricyclische triazolische verbindungen
UY29648A1 (es) Derivados de piridopirimidina, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones
MX2010004669A (es) Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.
MX2009000169A (es) Derivados de purinona como agonistas de hm74a.
BRPI0817747A8 (pt) Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico
DK2190426T3 (da) Griseofulvin-analoger til behandling af cancer ved hæmning af centrosomal clusterdannelse
BRPI0606639A2 (pt) novo processo para a preparação de indóis substituìdos
BRPI1014802B8 (pt) profármacos de triptolida.
AR058253A1 (es) Procedimiento para la preparacion de ferri-succinilcaseina
MX337320B (es) Análogos halogenados de agentes anti-fibroticos.

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/10/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/10/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B22E Other requirements [chapter 22.5 patent gazette]

Free format text: FORMULADA EXIGENCIA PARA ADEQUACAO OU CUMPRIMENTO DE DISPOSICOES LEGAIS NO PRAZO DE 60 (SESSENTA) DIAS DESTA DATA.

B16B Notification of grant cancelled [chapter 16.2 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 16.3 NA RPI NO 2629 DE 25/05/2021 POR TER SIDO INDEVIDA.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: RETIFICACAO REF. RPI 2623, DE 13/04/2021. PRAZO DE VALIDADE: 10 ANOS CONTADOS A PARTIR DE 13/04/2021, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME A ADI 5.529/DF, COM APOSTILAMENTO DO PRAZO DE VALIDADE DA PROTECAO DA MATERIA RELATIVA A PRODUTOS E PROCESSOS FARMACEUTICOS E EQUIPAMENTOS E/OU MATERIAIS DE USO EM SAUDE, PARA APLICACAO EM HUMANOS.