AR063227A1 - Procedimiento para la preparacion de pradofloxacina - Google Patents

Procedimiento para la preparacion de pradofloxacina

Info

Publication number
AR063227A1
AR063227A1 ARP070104475A ARP070104475A AR063227A1 AR 063227 A1 AR063227 A1 AR 063227A1 AR P070104475 A ARP070104475 A AR P070104475A AR P070104475 A ARP070104475 A AR P070104475A AR 063227 A1 AR063227 A1 AR 063227A1
Authority
AR
Argentina
Prior art keywords
pradofloxacine
preparation procedure
formula
preparation
pradofloxacin
Prior art date
Application number
ARP070104475A
Other languages
English (en)
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of AR063227A1 publication Critical patent/AR063227A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente se refiere a un procedimiento mejorado para la preparacion de pradofloxacina, en el que se introduce un sustituyente en la posicion 7 mediante sustitucion nucleofila en una mezcla de disolventes de N-metilpirroIidona-etano. Reivindicacion 1: Un procedimiento para la preparacion de pradofloxacina de formula (1) mediante la reaccion, dado el caso en presencia e una base, del compuesto de formula (2) con (1S,6S)-2,8-diazabiciclo[4.3.0]nonato de formula (3) en una mezcla de disolventes de N-metilpirrolidona y etanol.
ARP070104475A 2006-10-20 2007-10-10 Procedimiento para la preparacion de pradofloxacina AR063227A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006049520A DE102006049520A1 (de) 2006-10-20 2006-10-20 Verfahren zur Herstellung von Pradofloxacin

Publications (1)

Publication Number Publication Date
AR063227A1 true AR063227A1 (es) 2009-01-14

Family

ID=38982832

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104475A AR063227A1 (es) 2006-10-20 2007-10-10 Procedimiento para la preparacion de pradofloxacina

Country Status (22)

Country Link
US (1) US8497377B2 (es)
EP (1) EP2086976B1 (es)
JP (2) JP5830221B2 (es)
AR (1) AR063227A1 (es)
AT (1) ATE509930T1 (es)
AU (1) AU2007312599B2 (es)
BR (1) BRPI0718480B8 (es)
CA (1) CA2666932C (es)
CL (1) CL2007003007A1 (es)
DE (1) DE102006049520A1 (es)
DK (1) DK2086976T3 (es)
ES (1) ES2365637T3 (es)
MX (1) MX2009003200A (es)
NZ (1) NZ576333A (es)
PE (1) PE20081466A1 (es)
PL (1) PL2086976T3 (es)
PT (1) PT2086976E (es)
SI (1) SI2086976T1 (es)
TW (1) TW200823210A (es)
UY (1) UY30646A1 (es)
WO (1) WO2008046532A1 (es)
ZA (1) ZA200902530B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT882049E (pt) 1996-02-23 2003-04-30 Bayer Ag Acidos 8-ciano-1-ciclopropil-7-(2,8-diazabiciclo-¬4.3.0|nonan-8-il)-6-fluoro-1,4-dihidro-4-oxo-quinolino-carboxilicos eventualmente substituidos e seus derivados
DE19717231A1 (de) 1997-04-24 1998-10-29 Bayer Ag 3-Cyano-2,4,5-trifluor-benzoylfluorid
DE19733243A1 (de) * 1997-08-01 1999-02-04 Bayer Ag Verfahren zur Herstellung von 3-Cyano-2,4-dihalogen-5-fluor-benzoesäure
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE10134719A1 (de) 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
DE10224086A1 (de) 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10337191A1 (de) 2003-08-13 2005-03-17 Bayer Healthcare Ag Neue Verwendung von Chinolon-Antibiotika
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin

Also Published As

Publication number Publication date
PT2086976E (pt) 2011-07-27
CA2666932C (en) 2015-03-10
AU2007312599A1 (en) 2008-04-24
BRPI0718480B1 (pt) 2021-04-13
DE102006049520A1 (de) 2008-04-24
ATE509930T1 (de) 2011-06-15
WO2008046532A1 (de) 2008-04-24
ZA200902530B (en) 2010-07-28
CA2666932A1 (en) 2008-04-24
JP5830221B2 (ja) 2015-12-09
EP2086976A1 (de) 2009-08-12
PL2086976T3 (pl) 2011-10-31
DK2086976T3 (da) 2011-09-05
ES2365637T3 (es) 2011-10-07
US20090318700A1 (en) 2009-12-24
JP2010506865A (ja) 2010-03-04
BRPI0718480A2 (pt) 2014-02-18
BRPI0718480B8 (pt) 2022-09-20
EP2086976B1 (de) 2011-05-18
NZ576333A (en) 2011-12-22
AU2007312599B2 (en) 2013-11-14
MX2009003200A (es) 2009-04-07
SI2086976T1 (sl) 2011-09-30
US8497377B2 (en) 2013-07-30
UY30646A1 (es) 2008-05-31
JP2016028055A (ja) 2016-02-25
TW200823210A (en) 2008-06-01
PE20081466A1 (es) 2008-12-18
CL2007003007A1 (es) 2008-04-04

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