BRPI0718247B1 - Composto usado como inibidor do transportador de monoamina vesicular 2, composição farmacêutica compreendendo o dito composto e uso da dita composição farmacêutica no tratamento de transtornos hipercinéticos - Google Patents

Composto usado como inibidor do transportador de monoamina vesicular 2, composição farmacêutica compreendendo o dito composto e uso da dita composição farmacêutica no tratamento de transtornos hipercinéticos Download PDF

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Publication number
BRPI0718247B1
BRPI0718247B1 BRPI0718247-3A BRPI0718247A BRPI0718247B1 BR PI0718247 B1 BRPI0718247 B1 BR PI0718247B1 BR PI0718247 A BRPI0718247 A BR PI0718247A BR PI0718247 B1 BRPI0718247 B1 BR PI0718247B1
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BR
Brazil
Prior art keywords
compound
compounds
isobutyl
dimethoxy
isoquinolin
Prior art date
Application number
BRPI0718247-3A
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English (en)
Portuguese (pt)
Inventor
Kyle W. Gano
Nicole HARRIOTT
Original Assignee
Neurocrine Biosciences, Inc.
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Application filed by Neurocrine Biosciences, Inc. filed Critical Neurocrine Biosciences, Inc.
Publication of BRPI0718247A2 publication Critical patent/BRPI0718247A2/pt
Publication of BRPI0718247B1 publication Critical patent/BRPI0718247B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0718247-3A 2006-11-08 2007-11-08 Composto usado como inibidor do transportador de monoamina vesicular 2, composição farmacêutica compreendendo o dito composto e uso da dita composição farmacêutica no tratamento de transtornos hipercinéticos BRPI0718247B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86494406P 2006-11-08 2006-11-08
US60/864.944 2006-11-08
PCT/US2007/084176 WO2008058261A1 (en) 2006-11-08 2007-11-08 Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto

Publications (2)

Publication Number Publication Date
BRPI0718247A2 BRPI0718247A2 (pt) 2014-01-07
BRPI0718247B1 true BRPI0718247B1 (pt) 2021-09-21

Family

ID=39110526

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718247-3A BRPI0718247B1 (pt) 2006-11-08 2007-11-08 Composto usado como inibidor do transportador de monoamina vesicular 2, composição farmacêutica compreendendo o dito composto e uso da dita composição farmacêutica no tratamento de transtornos hipercinéticos

Country Status (16)

Country Link
US (2) US8039627B2 (enExample)
EP (1) EP2081929B1 (enExample)
JP (1) JP5290185B2 (enExample)
KR (1) KR101500766B1 (enExample)
CN (1) CN101553487B (enExample)
AU (1) AU2007317242B2 (enExample)
BR (1) BRPI0718247B1 (enExample)
CA (1) CA2668689C (enExample)
DK (1) DK2081929T3 (enExample)
EA (1) EA018378B1 (enExample)
ES (1) ES2402220T3 (enExample)
IL (1) IL198250A0 (enExample)
MX (1) MX2009004910A (enExample)
PL (1) PL2081929T3 (enExample)
PT (1) PT2081929E (enExample)
WO (1) WO2008058261A1 (enExample)

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Also Published As

Publication number Publication date
KR101500766B9 (ko) 2024-09-25
IL198250A0 (en) 2009-12-24
PL2081929T3 (pl) 2013-06-28
EP2081929A1 (en) 2009-07-29
US20080167337A1 (en) 2008-07-10
PT2081929E (pt) 2013-04-15
EA200970461A1 (ru) 2009-12-30
BRPI0718247A2 (pt) 2014-01-07
CA2668689C (en) 2015-12-29
WO2008058261A1 (en) 2008-05-15
AU2007317242A1 (en) 2008-05-15
ES2402220T8 (es) 2021-12-23
US8039627B2 (en) 2011-10-18
CA2668689A1 (en) 2008-05-15
AU2007317242B2 (en) 2013-08-01
EP2081929B1 (en) 2013-01-09
EA018378B1 (ru) 2013-07-30
KR20090079257A (ko) 2009-07-21
JP5290185B2 (ja) 2013-09-18
CN101553487A (zh) 2009-10-07
MX2009004910A (es) 2009-07-24
ES2402220T3 (es) 2013-04-29
US8357697B2 (en) 2013-01-22
CN101553487B (zh) 2012-06-13
JP2010509366A (ja) 2010-03-25
US20120077839A1 (en) 2012-03-29
KR101500766B1 (ko) 2015-03-16
DK2081929T3 (da) 2013-04-15

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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/11/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.