BRPI0714945B8 - composições de análogo de rapamicina e processos para preparação de formas cristalinas de análogos de rapamicinas - Google Patents
composições de análogo de rapamicina e processos para preparação de formas cristalinas de análogos de rapamicinasInfo
- Publication number
- BRPI0714945B8 BRPI0714945B8 BRPI0714945A BRPI0714945A BRPI0714945B8 BR PI0714945 B8 BRPI0714945 B8 BR PI0714945B8 BR PI0714945 A BRPI0714945 A BR PI0714945A BR PI0714945 A BRPI0714945 A BR PI0714945A BR PI0714945 B8 BRPI0714945 B8 BR PI0714945B8
- Authority
- BR
- Brazil
- Prior art keywords
- rapamycin
- crystalline forms
- processes
- analogues
- preparing crystalline
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
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- Dermatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
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Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82031706P | 2006-07-25 | 2006-07-25 | |
| US60/820.317 | 2006-07-25 | ||
| US60/820,317 | 2006-07-25 | ||
| US11/781,804 US7812032B2 (en) | 2006-07-25 | 2007-07-23 | Crystalline forms of rapamycin analogs |
| US11/781,814 | 2007-07-23 | ||
| US11/781.807 | 2007-07-23 | ||
| US11/781,807 US7820812B2 (en) | 2006-07-25 | 2007-07-23 | Methods of manufacturing crystalline forms of rapamycin analogs |
| US11/781,807 | 2007-07-23 | ||
| US11/781.804 | 2007-07-23 | ||
| PCT/US2007/074159 WO2008014222A1 (en) | 2006-07-25 | 2007-07-24 | Crystalline forms of rapamycin analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0714945A2 BRPI0714945A2 (pt) | 2013-05-21 |
| BRPI0714945B1 BRPI0714945B1 (pt) | 2020-11-10 |
| BRPI0714945B8 true BRPI0714945B8 (pt) | 2021-05-25 |
Family
ID=38562825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0714945A BRPI0714945B8 (pt) | 2006-07-25 | 2007-07-24 | composições de análogo de rapamicina e processos para preparação de formas cristalinas de análogos de rapamicinas |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP2051984A1 (https=) |
| JP (1) | JP2010500286A (https=) |
| KR (1) | KR20090035716A (https=) |
| AU (1) | AU2007276837B2 (https=) |
| BR (1) | BRPI0714945B8 (https=) |
| CA (1) | CA2658896A1 (https=) |
| IL (1) | IL196706A0 (https=) |
| MX (1) | MX2009001067A (https=) |
| NZ (1) | NZ574654A (https=) |
| WO (1) | WO2008014222A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820812B2 (en) | 2006-07-25 | 2010-10-26 | Abbott Laboratories | Methods of manufacturing crystalline forms of rapamycin analogs |
| US7812032B2 (en) | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
| CA2673991C (en) | 2007-01-21 | 2012-02-07 | Hemoteq Ag | Methods for coating catheter balloons with a defined quantity of active agent |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| EP2380006A4 (en) * | 2009-01-21 | 2012-05-16 | Biocon Ltd | PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM |
| ES2550634T3 (es) | 2009-07-10 | 2015-11-11 | Boston Scientific Scimed, Inc. | Uso de nanocristales para un balón de suministro de fármaco |
| EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| WO2013022458A1 (en) * | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| US9439892B2 (en) | 2013-05-16 | 2016-09-13 | Surmodics, Inc. | Macrolide particulates, methods for preparation, and medical devices associated therewith |
| CA2915704C (en) | 2013-06-12 | 2022-06-21 | Surmodics, Inc. | Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates |
| DE102013110294B4 (de) * | 2013-09-18 | 2016-07-07 | Innora Gmbh | Limus-Depot-Formulierung auf Ballonkathetern |
| EP3435988B1 (en) | 2016-03-31 | 2021-10-06 | Surmodics, Inc. | Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment |
| US11123459B2 (en) | 2016-12-16 | 2021-09-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
| CN108144131A (zh) * | 2017-12-22 | 2018-06-12 | 上海微创医疗器械（集团）有限公司 | 一种载药植入医疗器械及其制备方法 |
| CN119431400A (zh) * | 2020-03-27 | 2025-02-14 | 波士顿科学国际有限公司 | 用于使药物结晶的方法 |
| JP2024503898A (ja) * | 2021-01-22 | 2024-01-29 | ヤンセン ファーマシューティカ エヌ．ベー． | ラパマイシン類似体及びその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
| US6015815A (en) * | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| TW557297B (en) * | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| US7645876B2 (en) * | 2004-12-01 | 2010-01-12 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | Processes for producing crystalline macrolides |
| AR050374A1 (es) * | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
-
2007
- 2007-07-24 JP JP2009521936A patent/JP2010500286A/ja active Pending
- 2007-07-24 AU AU2007276837A patent/AU2007276837B2/en active Active
- 2007-07-24 EP EP07799771A patent/EP2051984A1/en not_active Withdrawn
- 2007-07-24 WO PCT/US2007/074159 patent/WO2008014222A1/en not_active Ceased
- 2007-07-24 EP EP11183446A patent/EP2407471A3/en not_active Withdrawn
- 2007-07-24 NZ NZ574654A patent/NZ574654A/en unknown
- 2007-07-24 BR BRPI0714945A patent/BRPI0714945B8/pt active IP Right Grant
- 2007-07-24 CA CA002658896A patent/CA2658896A1/en not_active Abandoned
- 2007-07-24 MX MX2009001067A patent/MX2009001067A/es active IP Right Grant
- 2007-07-24 KR KR1020097003955A patent/KR20090035716A/ko not_active Ceased
-
2009
- 2009-01-25 IL IL196706A patent/IL196706A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010500286A (ja) | 2010-01-07 |
| EP2407471A2 (en) | 2012-01-18 |
| BRPI0714945A2 (pt) | 2013-05-21 |
| EP2407471A3 (en) | 2012-06-20 |
| EP2051984A1 (en) | 2009-04-29 |
| MX2009001067A (es) | 2009-06-17 |
| IL196706A0 (en) | 2009-11-18 |
| KR20090035716A (ko) | 2009-04-10 |
| BRPI0714945B1 (pt) | 2020-11-10 |
| WO2008014222A1 (en) | 2008-01-31 |
| CA2658896A1 (en) | 2008-01-31 |
| AU2007276837A1 (en) | 2008-01-31 |
| AU2007276837B2 (en) | 2013-02-07 |
| NZ574654A (en) | 2012-03-30 |
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