AU2007276837B2 - Crystalline forms of rapamycin analogs - Google Patents

Crystalline forms of rapamycin analogs Download PDF

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Publication number
AU2007276837B2
AU2007276837B2 AU2007276837A AU2007276837A AU2007276837B2 AU 2007276837 B2 AU2007276837 B2 AU 2007276837B2 AU 2007276837 A AU2007276837 A AU 2007276837A AU 2007276837 A AU2007276837 A AU 2007276837A AU 2007276837 B2 AU2007276837 B2 AU 2007276837B2
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Prior art keywords
rapamycin analog
crystalline
solvate
powder
compound
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AU2007276837A1 (en
Inventor
Larry Bartelt
Thomas Borchardt
Shuang Chen
Madhup Dhaon
Rodger Henry
Robert Leanna
Michael Rasmussen
Shekhar Viswanath
Geoff Zhang
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Abbott Laboratories
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Abbott Laboratories
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Priority claimed from US11/781,804 external-priority patent/US7812032B2/en
Priority claimed from US11/781,807 external-priority patent/US7820812B2/en
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
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AU2007276837A 2006-07-25 2007-07-24 Crystalline forms of rapamycin analogs Active AU2007276837B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US82031706P 2006-07-25 2006-07-25
US60/820,317 2006-07-25
US11/781,804 US7812032B2 (en) 2006-07-25 2007-07-23 Crystalline forms of rapamycin analogs
US11/781,804 2007-07-23
US11/781,807 US7820812B2 (en) 2006-07-25 2007-07-23 Methods of manufacturing crystalline forms of rapamycin analogs
US11/781,807 2007-07-23
PCT/US2007/074159 WO2008014222A1 (en) 2006-07-25 2007-07-24 Crystalline forms of rapamycin analogs

Publications (2)

Publication Number Publication Date
AU2007276837A1 AU2007276837A1 (en) 2008-01-31
AU2007276837B2 true AU2007276837B2 (en) 2013-02-07

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AU2007276837A Active AU2007276837B2 (en) 2006-07-25 2007-07-24 Crystalline forms of rapamycin analogs

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EP (2) EP2051984A1 (https=)
JP (1) JP2010500286A (https=)
KR (1) KR20090035716A (https=)
AU (1) AU2007276837B2 (https=)
BR (1) BRPI0714945B8 (https=)
CA (1) CA2658896A1 (https=)
IL (1) IL196706A0 (https=)
MX (1) MX2009001067A (https=)
NZ (1) NZ574654A (https=)
WO (1) WO2008014222A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820812B2 (en) 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
US7812032B2 (en) 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
CA2673991C (en) 2007-01-21 2012-02-07 Hemoteq Ag Methods for coating catheter balloons with a defined quantity of active agent
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2380006A4 (en) * 2009-01-21 2012-05-16 Biocon Ltd PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM
ES2550634T3 (es) 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Uso de nanocristales para un balón de suministro de fármaco
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
WO2013022458A1 (en) * 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
CA2915704C (en) 2013-06-12 2022-06-21 Surmodics, Inc. Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates
DE102013110294B4 (de) * 2013-09-18 2016-07-07 Innora Gmbh Limus-Depot-Formulierung auf Ballonkathetern
EP3435988B1 (en) 2016-03-31 2021-10-06 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
CN108144131A (zh) * 2017-12-22 2018-06-12 上海微创医疗器械（集团）有限公司 一种载药植入医疗器械及其制备方法
CN119431400A (zh) * 2020-03-27 2025-02-14 波士顿科学国际有限公司 用于使药物结晶的方法
JP2024503898A (ja) * 2021-01-22 2024-01-29 ヤンセン ファーマシューティカ エヌ．ベー． ラパマイシン類似体及びその使用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
TW557297B (en) * 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
WO2001051919A2 (en) * 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US7645876B2 (en) * 2004-12-01 2010-01-12 TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság Processes for producing crystalline macrolides
AR050374A1 (es) * 2004-08-20 2006-10-18 Wyeth Corp Forma polimorfica de rafampicina

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives

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