BRPI0712030A2 - formas cristalinas e processos para preparaÇço de fenil-pirazàis éteis como moduladores dos receptores de serotonina 5-h-t2a - Google Patents

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Publication number

BRPI0712030A2

BRPI0712030A2 BRPI0712030-3A BRPI0712030A BRPI0712030A2 BR PI0712030 A2 BRPI0712030 A2 BR PI0712030A2 BR PI0712030 A BRPI0712030 A BR PI0712030A BR PI0712030 A2 BRPI0712030 A2 BR PI0712030A2

Authority

BR

Brazil

Prior art keywords

formula

compound

approximately

alkyl

process according

Prior art date

2006-05-18

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• 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title abstract description 3
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• 239000002904 solvent Substances 0.000 claims description 82
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 77
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• 208000035475 disorder Diseases 0.000 claims description 51
• 125000005843 halogen group Chemical group 0.000 claims description 51
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 49
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 48
• 125000001188 haloalkyl group Chemical group 0.000 claims description 45
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
• 125000003342 alkenyl group Chemical group 0.000 claims description 40
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 39
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• 238000000634 powder X-ray diffraction Methods 0.000 claims description 39
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 38
• 125000003118 aryl group Chemical group 0.000 claims description 38
• 125000001072 heteroaryl group Chemical group 0.000 claims description 38
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 37
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• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 4
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• 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
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