BRPI0616658A2 - composto, uso de um composto, e, formulação farmacêutica - Google Patents

Info

Publication number

BRPI0616658A2

BRPI0616658A2 BRPI0616658-0A BRPI0616658A BRPI0616658A2 BR PI0616658 A2 BRPI0616658 A2 BR PI0616658A2 BR PI0616658 A BRPI0616658 A BR PI0616658A BR PI0616658 A2 BRPI0616658 A2 BR PI0616658A2

Authority

BR

Brazil

Prior art keywords

methyl

imidazol

pyrimidin

fluoro

alkyl

Prior art date

2005-10-03

Links

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• Global Dossier
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• 150000001875 compounds Chemical class 0.000 title claims abstract description 441
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
• 150000003839 salts Chemical class 0.000 claims abstract description 40
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 23
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• 230000007170 pathology Effects 0.000 claims abstract description 4
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 123
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 120
• 239000001257 hydrogen Substances 0.000 claims description 106
• 229910052739 hydrogen Inorganic materials 0.000 claims description 106
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• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 86
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 86
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 84
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• LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 claims description 48
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• MPVDXIMFBOLMNW-UHFFFAOYSA-N chembl1615565 Chemical group OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1N=NC1=CC=CC=C1 MPVDXIMFBOLMNW-UHFFFAOYSA-N 0.000 claims description 37
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 30
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• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 9
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• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
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• WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 8
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• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
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• 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims description 2
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 2
• KKQCMKIHBRHEFZ-UHFFFAOYSA-N 5-fluoro-4-[2-methyl-3-(oxan-4-yl)imidazol-4-yl]-n-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrimidin-2-amine Chemical compound C1CN(C)CCN1S(=O)(=O)C(C=C1)=CC=C1NC1=NC=C(F)C(C=2N(C(C)=NC=2)C2CCOCC2)=N1 KKQCMKIHBRHEFZ-UHFFFAOYSA-N 0.000 claims description 2
• BFOFJQKSDHSGBI-UHFFFAOYSA-N 5-fluoro-n-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-4-[3-(oxan-4-yl)-2-(trifluoromethyl)imidazol-4-yl]pyrimidin-2-amine Chemical compound C1CN(C)CCN1S(=O)(=O)C(C=C1)=CC=C1NC1=NC=C(F)C(C=2N(C(=NC=2)C(F)(F)F)C2CCOCC2)=N1 BFOFJQKSDHSGBI-UHFFFAOYSA-N 0.000 claims description 2
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• UDJXDSRTPPWHOA-UHFFFAOYSA-N [4-[[5-fluoro-4-[2-methyl-3-(oxan-4-yl)imidazol-4-yl]pyrimidin-2-yl]amino]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C(F)C(C=2N(C(C)=NC=2)C2CCOCC2)=N1 UDJXDSRTPPWHOA-UHFFFAOYSA-N 0.000 claims description 2
• 206010068168 androgenetic alopecia Diseases 0.000 claims description 2
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• DXASQZJWWGZNSF-UHFFFAOYSA-N n,n-dimethylmethanamine;sulfur trioxide Chemical group CN(C)C.O=S(=O)=O DXASQZJWWGZNSF-UHFFFAOYSA-N 0.000 claims description 2
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