RU2433128C2 - Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера - Google Patents

Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера Download PDF

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Publication number
RU2433128C2
RU2433128C2 RU2008110910/04A RU2008110910A RU2433128C2 RU 2433128 C2 RU2433128 C2 RU 2433128C2 RU 2008110910/04 A RU2008110910/04 A RU 2008110910/04A RU 2008110910 A RU2008110910 A RU 2008110910A RU 2433128 C2 RU2433128 C2 RU 2433128C2
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Russia
Prior art keywords
methyl
imidazol
pyrimidin
fluoro
alkyl
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RU2008110910/04A
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English (en)
Russian (ru)
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RU2008110910A (ru
Inventor
Ларс АНДЕРССОН (SE)
Ларс Андерссон
Эрван АРЗЕЛЬ (SE)
Эрван Арзель
Стефан БЕРГ (SE)
Стефан Берг
Джереми БАРРОУЗ (SE)
Джереми БАРРОУЗ
Свен ХЕЛЛЬБЕРГ (SE)
Свен ХЕЛЛЬБЕРГ
Фернандо ХУЭРТА (SE)
Фернандо ХУЭРТА
Торбен ПЕДЕРСЕН (SE)
Торбен Педерсен
Тобиас РЕЙН (SE)
Тобиас Рейн
Дидье РОТТИЧЧИ (SE)
Дидье Роттиччи
Карин СТААФ (SE)
Карин Стааф
Доминика ТУРЕК (SE)
Доминика Турек
Original Assignee
Астразенека Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2008110910/04A 2005-10-03 2006-10-02 Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера RU2433128C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0502174 2005-10-03
SE0502174-6 2005-10-03

Related Child Applications (1)

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RU2011115406/04A Division RU2011115406A (ru) 2005-10-03 2011-04-20 Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера

Publications (2)

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RU2008110910A RU2008110910A (ru) 2009-11-10
RU2433128C2 true RU2433128C2 (ru) 2011-11-10

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RU2008110910/04A RU2433128C2 (ru) 2005-10-03 2006-10-02 Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера
RU2011115406/04A RU2011115406A (ru) 2005-10-03 2011-04-20 Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера

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RU2011115406/04A RU2011115406A (ru) 2005-10-03 2011-04-20 Новые пиримидиновые производные и их применение в терапии, а также применение пиримидиновых производных в изготовлении лекарственного средства для предупреждения и/или лечения болезни альцгеймера

Country Status (20)

Country Link
US (1) US20090105252A1 (enExample)
EP (1) EP1945628A4 (enExample)
JP (1) JP2009513575A (enExample)
KR (1) KR20080059423A (enExample)
CN (1) CN101326179A (enExample)
AR (1) AR058073A1 (enExample)
AU (2) AU2006297890B2 (enExample)
BR (1) BRPI0616658A2 (enExample)
CA (1) CA2624875A1 (enExample)
EC (1) ECSP088405A (enExample)
IL (1) IL190150A0 (enExample)
NO (1) NO20082067L (enExample)
NZ (2) NZ566804A (enExample)
RU (2) RU2433128C2 (enExample)
SG (1) SG166125A1 (enExample)
TW (1) TW200800957A (enExample)
UA (1) UA92181C2 (enExample)
UY (1) UY29827A1 (enExample)
WO (1) WO2007040440A1 (enExample)
ZA (1) ZA200802897B (enExample)

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RU2825827C1 (ru) * 2020-03-23 2024-08-30 Ван Ин Фармасьютикал Ко., Лтд. Новое производное пиримидина и содержащая его композиция для предупреждения или лечения нейродегенеративных заболеваний и рака

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JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
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CA3172750A1 (en) * 2020-03-23 2021-09-30 Ge Hyeong Lee Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same
KR102342803B1 (ko) * 2020-03-23 2021-12-24 환인제약 주식회사 신규한 피리미딘 유도체 및 이를 포함하는 신경퇴행성 질환 및 암의 예방 또는 치료용 조성물
TW202227401A (zh) * 2020-10-23 2022-07-16 大陸商重慶兩江藥物研發中心有限公司 用於持續釋放治療劑的前藥及其用途
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2825827C1 (ru) * 2020-03-23 2024-08-30 Ван Ин Фармасьютикал Ко., Лтд. Новое производное пиримидина и содержащая его композиция для предупреждения или лечения нейродегенеративных заболеваний и рака
RU2825827C9 (ru) * 2020-03-23 2024-12-16 Ван Ин Фармасьютикал Ко., Лтд. Новое производное пиримидина и содержащая его композиция для предупреждения или лечения нейродегенеративных заболеваний и рака

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Publication number Publication date
EP1945628A1 (en) 2008-07-23
AR058073A1 (es) 2008-01-23
UA92181C2 (ru) 2010-10-11
AU2006297890B2 (en) 2011-04-28
EP1945628A4 (en) 2010-06-02
RU2011115406A (ru) 2012-10-27
AU2011200948A1 (en) 2011-03-24
NZ566804A (en) 2011-03-31
AU2006297890A1 (en) 2007-04-12
US20090105252A1 (en) 2009-04-23
UY29827A1 (es) 2007-05-31
CN101326179A (zh) 2008-12-17
RU2008110910A (ru) 2009-11-10
IL190150A0 (en) 2008-08-07
WO2007040440A1 (en) 2007-04-12
BRPI0616658A2 (pt) 2011-06-28
TW200800957A (en) 2008-01-01
NO20082067L (no) 2008-07-02
ZA200802897B (en) 2008-12-31
NZ591316A (en) 2012-06-29
JP2009513575A (ja) 2009-04-02
ECSP088405A (es) 2008-05-30
CA2624875A1 (en) 2007-04-12
KR20080059423A (ko) 2008-06-27
SG166125A1 (en) 2010-11-29

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