BRPI0607739A2 - derivados de tetraidroindolona e tetraidroindazolona, composição compreendendo os mesmos e uso relacionado - Google Patents

derivados de tetraidroindolona e tetraidroindazolona, composição compreendendo os mesmos e uso relacionado

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Publication number
BRPI0607739A2
BRPI0607739A2 BRPI0607739-0A BRPI0607739A BRPI0607739A2 BR PI0607739 A2 BRPI0607739 A2 BR PI0607739A2 BR PI0607739 A BRPI0607739 A BR PI0607739A BR PI0607739 A2 BRPI0607739 A2 BR PI0607739A2
Authority
BR
Brazil
Prior art keywords
compounds
composition
tetrahydroindolone
related use
derivatives
Prior art date
Application number
BRPI0607739-0A
Other languages
English (en)
Inventor
Kenneth He Huang
Jeron Eaves
Thomas E Barta
Lifeng Geng
Lindsay Hinkley
Gunnar Hanson
James Veal
Original Assignee
Serenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serenex Inc filed Critical Serenex Inc
Publication of BRPI0607739A2 publication Critical patent/BRPI0607739A2/pt

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Plural Heterocyclic Compounds (AREA)
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Abstract

DERIVADOS DE TETRAIDROINDOLONA E TETRAIDROINDAZOLONA, COMPOSIçãO COMPREENDENDO OS MESMOS E USO RELACIONADO. A presente invenção refere-se a compostos e sais farmaceuticamente aceitáveis da Fórmula 1: em que R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 7~, n, Q1, Q2, Q3, Y, e X~ 1~-X~ 4~ são como definidos aqui. Compostos da fórmula I são úteis no tratamento de doenças e/ou condições relacionadas à proliferação celular, como câncer, inflamação, artrite, angiogênese, ou outras. Também refere-se a composições farmacêuticas compreendendo os compostos da invenção e métodos de tratar as condições acima mencionadas usando tais compostos.
BRPI0607739-0A 2005-02-25 2006-02-27 derivados de tetraidroindolona e tetraidroindazolona, composição compreendendo os mesmos e uso relacionado BRPI0607739A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65623005P 2005-02-25 2005-02-25
US70571505P 2005-08-04 2005-08-04
US72796505P 2005-10-18 2005-10-18
PCT/US2006/006988 WO2006091963A1 (en) 2005-02-25 2006-02-27 Tetrahydroindolone and tetrahydroindazolone derivatives

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BRPI0607739A2 true BRPI0607739A2 (pt) 2009-09-29

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US (8) US7358370B2 (pt)
EP (2) EP1856057B1 (pt)
JP (1) JP4377942B2 (pt)
KR (3) KR20070114763A (pt)
CN (1) CN101180275B (pt)
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