FR2955323B1 - Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation - Google Patents

Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Info

Publication number
FR2955323B1
FR2955323B1 FR1050341A FR1050341A FR2955323B1 FR 2955323 B1 FR2955323 B1 FR 2955323B1 FR 1050341 A FR1050341 A FR 1050341A FR 1050341 A FR1050341 A FR 1050341A FR 2955323 B1 FR2955323 B1 FR 2955323B1
Authority
FR
France
Prior art keywords
hsp90
compositions containing
containing same
indazole derivatives
novel indazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1050341A
Other languages
English (en)
Other versions
FR2955323A1 (fr
Inventor
Luc Bertin
Jean Christophe Carry
Patrick Mailliet
Herve Minoux
Fabienne Pilorge
Jean Marie Ruxer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1050341A priority Critical patent/FR2955323B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to EP10715951A priority patent/EP2408762A1/fr
Priority to MX2011009806A priority patent/MX2011009806A/es
Priority to KR1020117024518A priority patent/KR20110128942A/ko
Priority to CA2755660A priority patent/CA2755660A1/fr
Priority to TW099108049A priority patent/TW201038553A/zh
Priority to PCT/FR2010/050483 priority patent/WO2010106290A1/fr
Priority to JP2012500297A priority patent/JP2012520859A/ja
Priority to AU2010224652A priority patent/AU2010224652A1/en
Priority to RU2011142151/04A priority patent/RU2011142151A/ru
Priority to CN2010800219733A priority patent/CN102439003A/zh
Priority to SG2011067634A priority patent/SG174466A1/en
Priority to US13/257,516 priority patent/US20120010241A1/en
Priority to ARP100100858A priority patent/AR075874A1/es
Priority to BRPI1009375A priority patent/BRPI1009375A2/pt
Priority to UY0001032505A priority patent/UY32505A/es
Publication of FR2955323A1 publication Critical patent/FR2955323A1/fr
Priority to IL215139A priority patent/IL215139A0/en
Application granted granted Critical
Publication of FR2955323B1 publication Critical patent/FR2955323B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1050341A 2009-03-19 2010-01-19 Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation Expired - Fee Related FR2955323B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR1050341A FR2955323B1 (fr) 2010-01-19 2010-01-19 Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
US13/257,516 US20120010241A1 (en) 2009-03-19 2010-03-18 Hsp90 inhibiting indazole derivatives, compositions containing same and use thereof
KR1020117024518A KR20110128942A (ko) 2009-03-19 2010-03-18 Ｈｓｐ９０ 억제 인다졸 유도체, 그를 함유하는 조성물 및 그의 용도
CA2755660A CA2755660A1 (fr) 2009-03-19 2010-03-18 Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
TW099108049A TW201038553A (en) 2009-03-19 2010-03-18 Novel indazole derivatives which inhibit HSP90, compositions containing them and use thereof
PCT/FR2010/050483 WO2010106290A1 (fr) 2009-03-19 2010-03-18 Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
JP2012500297A JP2012520859A (ja) 2009-03-19 2010-03-18 Ｓｈｐ９０阻害性インダゾール誘導体、これらを含有する組成物、およびこれらの使用
AU2010224652A AU2010224652A1 (en) 2009-03-19 2010-03-18 Hsp90 inhibiting indazole derivatives, compositions containing same and use thereof
EP10715951A EP2408762A1 (fr) 2009-03-19 2010-03-18 Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation
CN2010800219733A CN102439003A (zh) 2009-03-19 2010-03-18 抑制hsp90的吲唑衍生物、含有所述衍生物的组合物及其用途
SG2011067634A SG174466A1 (en) 2009-03-19 2010-03-18 Hsp90 inhibiting indazole derivatives, compositions containing same and use thereof
MX2011009806A MX2011009806A (es) 2009-03-19 2010-03-18 Nuevos derivados de indazol inhibidores de hsp90, composiciones que los contienen y su uso.
ARP100100858A AR075874A1 (es) 2009-03-19 2010-03-18 Derivados de indazol inhibidores de hsp90 composiciones que los contienen y utilizacion
BRPI1009375A BRPI1009375A2 (pt) 2009-03-19 2010-03-18 derivados inibidores de hsp90, composições que os contém e utilização
RU2011142151/04A RU2011142151A (ru) 2009-03-19 2010-03-18 Производные индазола-ингибиторы hsp90, содержащие их композиции и применение
UY0001032505A UY32505A (es) 2009-03-19 2010-03-19 Nuevos derivados de indazol inhibidores de hsp90, composiciones que los contienen y su utilización
IL215139A IL215139A0 (en) 2009-03-19 2011-09-14 Hsp90 inhibiting indazole derivatives, compositions containing same and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1050341A FR2955323B1 (fr) 2010-01-19 2010-01-19 Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
FR2955323A1 FR2955323A1 (fr) 2011-07-22
FR2955323B1 true FR2955323B1 (fr) 2015-01-16

Family

ID=42370980

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1050341A Expired - Fee Related FR2955323B1 (fr) 2009-03-19 2010-01-19 Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation

Country Status (1)

Country Link
FR (1) FR2955323B1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527770T3 (es) * 2005-02-25 2015-01-29 Serenex, Inc. Derivados de tetrahidroindolona y tetrahidroindazolona
JP2007145786A (ja) * 2005-11-30 2007-06-14 Toray Ind Inc ピラジン誘導体及びそれを有効成分とする腎炎治療薬
JP2009527562A (ja) * 2006-02-21 2009-07-30 アムゲン インコーポレイティッド ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体
US20090170898A1 (en) * 2006-03-31 2009-07-02 Malena Bengtsson Sulphonamide Derivatives as Modulators of the Glucocorticoid Receptor
JP2010501593A (ja) * 2006-08-24 2010-01-21 セレネックス， インコーポレイテッド イソキノリン、キナゾリンおよびフタラジン誘導体

Also Published As

Publication number Publication date
FR2955323A1 (fr) 2011-07-22

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