BRPI0517333A - solução de conservação e perfusão de órgãos para manter a viabilidade do órgão doador, e, método para conservar um órgão - Google Patents

solução de conservação e perfusão de órgãos para manter a viabilidade do órgão doador, e, método para conservar um órgão

Info

Publication number
BRPI0517333A
BRPI0517333A BRPI0517333-7A BRPI0517333A BRPI0517333A BR PI0517333 A BRPI0517333 A BR PI0517333A BR PI0517333 A BRPI0517333 A BR PI0517333A BR PI0517333 A BRPI0517333 A BR PI0517333A
Authority
BR
Brazil
Prior art keywords
organ
solution
perfusion
organs
maintain
Prior art date
Application number
BRPI0517333-7A
Other languages
English (en)
Inventor
Benedict Marie Doorschodt
Maud Bessems
Original Assignee
Doorzand Airdrive B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Doorzand Airdrive B V filed Critical Doorzand Airdrive B V
Publication of BRPI0517333A publication Critical patent/BRPI0517333A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SOLUçãO DE CONSERVAçãO E PERFUSãO DE óRGáOS PARA MANTER A VIABILIDADE DO óRGãO DOADOR, E, MéTODO PARA CONSERVAR UM óRGãO. A presente invenção provê uma nova solução de conservação de órgáos, apropriada para perfusão em máquina, para manter a viabilidade dos órgáos, partes de órgãos e tecidos. Esta solução foi projetada para superar vários problemas associados com a perfusão em máquina hipotérmica de órgáos de doadores, particularmente os órgãos obtidos de doadores sem batimento cardíaco. A solução evita ou minimiza os efeitos adversos causados por danos de isquemia, hipoxia, depleção de nutrientes e energia, acidificação, hipotermia, e de reperfusão. As soluções de conservação de acordo com a presente invenção são superiores ao estado real das soluções de conservação da técnica, em particular, para conservações e perfusão de órgáos obtidos dos doares sem batimento cardíaco, ao suprir concentrações aumentadas e um equilíbrio otimizado de aminoácidos, vitaminas, antioxidantes, aditivos de peso molecular elevado e melhorada capacidade de tamponamento. Em adição, a solução de conservação de acordo com a invenção combina propriedades fisicas e químicas com o uso de compostos aceitáveis e testados farmaceuticamente, economicamente e prontamente disponíveis, reduzindo o custo de fabricação e facilitando certificação médica de soluções de acordo com a presente invenção.
BRPI0517333-7A 2004-11-12 2005-11-11 solução de conservação e perfusão de órgãos para manter a viabilidade do órgão doador, e, método para conservar um órgão BRPI0517333A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04078113 2004-11-12
PCT/NL2005/050036 WO2006052133A2 (en) 2004-11-12 2005-11-11 Composition for cold preservation and perfusion of organs

Publications (1)

Publication Number Publication Date
BRPI0517333A true BRPI0517333A (pt) 2008-10-07

Family

ID=34928658

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517333-7A BRPI0517333A (pt) 2004-11-12 2005-11-11 solução de conservação e perfusão de órgãos para manter a viabilidade do órgão doador, e, método para conservar um órgão

Country Status (9)

Country Link
US (1) US8637230B2 (pt)
EP (1) EP1809101B1 (pt)
JP (2) JP2008519830A (pt)
CN (1) CN101098622B (pt)
AU (1) AU2005302851B2 (pt)
BR (1) BRPI0517333A (pt)
CA (1) CA2587831C (pt)
WO (1) WO2006052133A2 (pt)
ZA (1) ZA200704147B (pt)

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Also Published As

Publication number Publication date
JP2008519830A (ja) 2008-06-12
WO2006052133A3 (en) 2006-10-19
ZA200704147B (en) 2008-10-29
CN101098622A (zh) 2008-01-02
EP1809101A2 (en) 2007-07-25
JP2013010771A (ja) 2013-01-17
CA2587831C (en) 2015-03-31
WO2006052133A2 (en) 2006-05-18
CA2587831A1 (en) 2006-05-18
AU2005302851B2 (en) 2012-02-23
EP1809101B1 (en) 2016-11-02
US8637230B2 (en) 2014-01-28
US20080187901A1 (en) 2008-08-07
AU2005302851A1 (en) 2006-05-18
CN101098622B (zh) 2010-08-11

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: PARA QUE SEJA ACEITA A PETICAO NO 020080141182/RJ DE 12/11/2008 APRESENTE PETICAO DE DESARQUIVAMENTO DO PEDIDO, BEM COMO A RETRIBUICAO RELATIVA AO CUMPRIMENTO DE EXIGENCIA.

B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REFERENTE A RPI 2038 DE 26/01/2010.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B25B Requested transfer of rights rejected

Owner name: DOORZAND AIRDRIVE B.V. (NL)

B25B Requested transfer of rights rejected

Owner name: DOORZAND AIRDRIVE B.V. (NL)