BRPI0418133A2 - pró-fármaco de florfenicol tendo solubilidade em água melhorada - Google Patents

pró-fármaco de florfenicol tendo solubilidade em água melhorada

Info

Publication number
BRPI0418133A2
BRPI0418133A2 BRPI0418133-6A BRPI0418133A BRPI0418133A2 BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2 BR PI0418133 A BRPI0418133 A BR PI0418133A BR PI0418133 A2 BRPI0418133 A2 BR PI0418133A2
Authority
BR
Brazil
Prior art keywords
florfenicol
water solubility
improved water
florfenicol prodrug
solubility
Prior art date
Application number
BRPI0418133-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Scott J Hecker
Sunil V Pansare
Tomasz W Glinka
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34738768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0418133(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of BRPI0418133A2 publication Critical patent/BRPI0418133A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0418133-6A 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada BRPI0418133A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53222703P 2003-12-23 2003-12-23
PCT/US2004/042591 WO2005063257A1 (en) 2003-12-23 2004-12-20 Florfenicol prodrug having improved water solubility

Publications (1)

Publication Number Publication Date
BRPI0418133A2 true BRPI0418133A2 (pt) 2009-03-24

Family

ID=34738768

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418133-6A BRPI0418133A2 (pt) 2003-12-23 2004-12-20 pró-fármaco de florfenicol tendo solubilidade em água melhorada

Country Status (18)

Country Link
US (2) US7153842B2 (cg-RX-API-DMAC10.html)
EP (1) EP1696934B1 (cg-RX-API-DMAC10.html)
JP (2) JP4719160B2 (cg-RX-API-DMAC10.html)
KR (1) KR20060111605A (cg-RX-API-DMAC10.html)
CN (1) CN100579532C (cg-RX-API-DMAC10.html)
AR (1) AR046970A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0418133A2 (cg-RX-API-DMAC10.html)
CA (1) CA2550660C (cg-RX-API-DMAC10.html)
EC (1) ECSP066670A (cg-RX-API-DMAC10.html)
IL (2) IL176342A (cg-RX-API-DMAC10.html)
MX (1) MXPA06007215A (cg-RX-API-DMAC10.html)
NO (1) NO20063244L (cg-RX-API-DMAC10.html)
NZ (1) NZ547592A (cg-RX-API-DMAC10.html)
PE (1) PE20050822A1 (cg-RX-API-DMAC10.html)
RU (1) RU2006126519A (cg-RX-API-DMAC10.html)
TW (1) TWI262181B (cg-RX-API-DMAC10.html)
WO (1) WO2005063257A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200605165B (cg-RX-API-DMAC10.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20050386A1 (es) 2003-05-29 2005-06-23 Schering Plough Ltd Composiciones farmaceuticas de florfenicol
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
EP1696934B1 (en) * 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
DE602005009381D1 (de) 2004-09-23 2008-10-09 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
JP4750126B2 (ja) 2004-11-19 2011-08-17 シェーリング−プラウ・リミテッド 殺寄生虫薬２−フェニル−３−（１ｈ−ピロール−２−イル）アクリロニトリル誘導体の使用による動物における寄生虫の制御
EP1890547A2 (en) * 2005-06-09 2008-02-27 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
WO2008076261A2 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble phenicol prodrugs in a lipophilic vehicle system
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (en) 2007-06-27 2015-11-16 Du Pont PROCEDURE TO COMBAT PESTS WITH ANIMALS
PE20091171A1 (es) * 2007-12-14 2009-08-03 Schering Plough Ltd Proceso para recuperar florfenicol y analogos de florfenicol
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
AU2010279587A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
EP2461684A2 (en) 2009-08-05 2012-06-13 E. I. du Pont de Nemours and Company Mesoionic pesticides
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
MX2013012820A (es) 2011-05-02 2014-02-10 Zoetis Llc Cefalosporinas novedosas utiles como agentes antibacteriales.
US20140113934A1 (en) 2011-06-20 2014-04-24 E I Du Pont De Nemours And Company Heterocyclic compounds for treating helminth infections
JP2015502936A (ja) 2011-11-28 2015-01-29 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ スルホンアミド駆虫薬
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
WO2014099837A1 (en) 2012-12-18 2014-06-26 E. I. Du Pont De Nemours And Company Sulfonamide anthelmintics
CN103242363B (zh) * 2013-04-18 2015-10-28 湖北龙翔药业有限公司 氟苯尼考磷酸二酯及盐及其制备方法
CN103923118A (zh) * 2014-04-08 2014-07-16 张家港威胜生物医药有限公司 一种水溶性氟苯尼考衍生物的合成方法
CN105111234B (zh) * 2015-09-23 2017-05-17 河北远征禾木药业有限公司 一种氟苯尼考磷酸酯的合成方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776992A (en) 1956-03-14 1957-01-08 Du Pont Trifluoromethylsulfonylphenyldichloracetamidopropandiol
US4235892A (en) 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
FR2562543B1 (fr) * 1984-04-10 1987-09-25 Elf Aquitaine Nouveaux phosphonites cycliques, leur preparation et applications
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
US6670344B2 (en) 2000-09-14 2003-12-30 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
US7547686B2 (en) 2001-06-15 2009-06-16 Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State University Combretastatin A-3 prodrug
AU2003249503A1 (en) * 2002-03-08 2003-09-29 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
EP1696934B1 (en) * 2003-12-23 2013-05-29 Schering-Plough Ltd. Florfenicol prodrug having improved water solubility
WO2005066119A2 (en) 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof

Also Published As

Publication number Publication date
EP1696934B1 (en) 2013-05-29
US7153842B2 (en) 2006-12-26
JP2011148804A (ja) 2011-08-04
NO20063244L (no) 2006-09-20
US20070021387A1 (en) 2007-01-25
MXPA06007215A (es) 2006-08-18
US20050182031A1 (en) 2005-08-18
AR046970A1 (es) 2006-01-04
IL200041A0 (en) 2010-04-15
EP1696934A1 (en) 2006-09-06
AU2004308913A1 (en) 2005-07-14
ECSP066670A (es) 2006-10-25
WO2005063257A1 (en) 2005-07-14
CN100579532C (zh) 2010-01-13
TW200533640A (en) 2005-10-16
US7572777B2 (en) 2009-08-11
TWI262181B (en) 2006-09-21
PE20050822A1 (es) 2005-10-01
JP2007516286A (ja) 2007-06-21
CN1897954A (zh) 2007-01-17
KR20060111605A (ko) 2006-10-27
RU2006126519A (ru) 2008-01-27
IL176342A (en) 2011-08-31
NZ547592A (en) 2009-07-31
CA2550660A1 (en) 2005-07-14
CA2550660C (en) 2011-03-15
IL176342A0 (en) 2006-10-05
ZA200605165B (en) 2007-12-27
JP4719160B2 (ja) 2011-07-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.

B15K Others concerning applications: alteration of classification

Ipc: C07F 9/09 (2006.01), A61P 31/00 (2006.01), C07F 9/